Gene-environment interaction: indexed research register 2020–2026

Article overview

A provenance-preserving register of the peer-reviewed literature Europe PMC indexes for gene-environment interaction, with publication types, journal spread and anchor records that any reader can resolve by DOI.

What this register counts

This page reports how much peer-reviewed literature is indexed on gene-environment interaction, not what that literature concludes. Every headline number comes from a live query against the whole Europe PMC index for the term “gene-environment interaction”, restricted to a first publication date between 2020-01-01 and 2026-08-23, and each query is published as a link you can open and re-run. On 2026-08-23 the term resolved to 6,258 records. These are complete counts over the index, not estimates and not a sample. A catalogue count is still a measurement of a catalogue, and a catalogue is not the state of knowledge.

Publication types and access

Publication type comes from the index metadata rather than from any reading of the articles. Of the 6,258 records, the index types 1,529 as a review or meta-analysis and 17 as a randomised controlled trial. 4,143 records are flagged open access, which means their full text can be read without payment and a reader can check any statement against the source. Records may carry more than one type, and records with no type assigned are counted in the total but in neither category, so the categories do not sum to the total and were never intended to.

How the literature is distributed

Counts by publication year run 2020: 939, 2021: 1,044, 2022: 829, 2023: 718, 2024: 808, 2025: 1,150, 2026: 761, with 2025 the heaviest year in the window. Within the 290 records Metatron Health holds in its dated local snapshot of 2026-08-23, the literature spans 187 distinct journals, led by: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik (10 records), PloS one (7 records), BMC plant biology (6 records), International journal of molecular sciences (6 records), Genes (6 records). That journal breakdown describes the captured snapshot rather than the full index, and is offered as an orientation to where this field publishes, not as a complete ranking.

What this register does not establish

A record count is not evidence of benefit, and being indexed is not endorsement by anyone, including us. This page carries no effect estimate, no comparison between treatments, no dose and no recommendation. A large literature can be large because a question is hard, commercially interesting, or repeatedly studied at low quality, and a captured subset can over-represent whichever records the index returned first. Anyone using this register to decide what to take or which practitioner to see is using it for something it was not built to do.

Anchor records and how to verify them

Each register names anchor records that a reader can resolve independently: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2026); Life (Basel, Switzerland) (2026); Pharmaceuticals (Basel, Switzerland) (2026); Nature genetics (2026). Anchors are selected deterministically, favouring reviews and trials, then open access, then citation count, with one record per journal. Records carrying a retraction or withdrawal notice in the index are excluded. Every anchor carries a DOI, its indexed grant support and its correction state as observed on 2026-08-23. Before this page was published, an independent review lane resolved every source URL listed below and recorded the hash of what it received.

Machine-readable reviewed statements

Sources and governing contracts

• SRC-EPMC-INDEX-GENE-ENVIRONMENT-INTERACTION — Europe PMC, EMBL-EBI, Europe PMC search index, records of any type: "gene-environment interaction" AND FIRST_PDATE:[2020-01-01 TO 2026-08-23]. Role: bibliographic index. Public literature index operated by EMBL-EBI. Metatron Health has no commercial or editorial relationship with the index operator and receives no payment connected to what it indexes. Open source
• SRC-EPMC-REVIEWS-GENE-ENVIRONMENT-INTERACTION — Europe PMC, EMBL-EBI, Europe PMC search index, records typed as a review or meta-analysis: "gene-environment interaction" AND FIRST_PDATE:[2020-01-01 TO 2026-08-23] AND PUB_TYPE:"Review". Role: bibliographic index. Public literature index operated by EMBL-EBI. Metatron Health has no commercial or editorial relationship with the index operator and receives no payment connected to what it indexes. Open source
• SRC-EPMC-TRIALS-GENE-ENVIRONMENT-INTERACTION — Europe PMC, EMBL-EBI, Europe PMC search index, records typed as a randomised controlled trial: "gene-environment interaction" AND FIRST_PDATE:[2020-01-01 TO 2026-08-23] AND PUB_TYPE:"Randomized Controlled Trial". Role: bibliographic index. Public literature index operated by EMBL-EBI. Metatron Health has no commercial or editorial relationship with the index operator and receives no payment connected to what it indexes. Open source
• SRC-EPMC-OPENACCESS-GENE-ENVIRONMENT-INTERACTION — Europe PMC, EMBL-EBI, Europe PMC search index, records whose full text is free to read: "gene-environment interaction" AND FIRST_PDATE:[2020-01-01 TO 2026-08-23] AND OPEN_ACCESS:y. Role: bibliographic index. Public literature index operated by EMBL-EBI. Metatron Health has no commercial or editorial relationship with the index operator and receives no payment connected to what it indexes. Open source
• SRC-EPMC-GENE-ENVIRONMENT-INTERACTION-01 — FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Gene-Environment Interactions in Childhood Asthma: From Prenatal Exposures to Targeted Interventions. Role: independent research. Independent peer-reviewed article. Metatron Health has no financial or editorial relationship with its authors, journal or funders and earns nothing from citing it. Open source
• SRC-EPMC-GENE-ENVIRONMENT-INTERACTION-02 — Life (Basel, Switzerland), From Serum to Genome: γ-Glutamyltransferase Gene Family Variants Shape Ischemic Stroke Risk via Sex-Specific Gene-Environment Interactions. Role: independent research. Independent peer-reviewed article. Metatron Health has no financial or editorial relationship with its authors, journal or funders and earns nothing from citing it. Open source
• SRC-EPMC-GENE-ENVIRONMENT-INTERACTION-03 — Pharmaceuticals (Basel, Switzerland), Metformin Treatment Potentially Modifies Genetically Driven Metabolite-HbA1c Associations: A Gene-Environment Interaction Mendelian Randomization Study. Role: independent research. Independent peer-reviewed article. Metatron Health has no financial or editorial relationship with its authors, journal or funders and earns nothing from citing it. Open source
• SRC-EPMC-GENE-ENVIRONMENT-INTERACTION-04 — Nature genetics, Estimation of direct and indirect polygenic effects and gene-environment interactions using polygenic scores in case-parent trio studies. Role: independent research. Independent peer-reviewed article. Metatron Health has no financial or editorial relationship with its authors, journal or funders and earns nothing from citing it. Open source