Research · Evidence register · The microbiome

The microbiome: indexed research register 2020–2026

The Europe PMC index holds 241,485 records for the microbiome published between 2020 and 2026, of which 64,413 are typed as reviews and 3,621 as randomised controlled trials. This register reports what the literature contains and how to reach it, never whether a practice works.

Indexed records
241485
Reviews
64413
Trials
3621
Open access
166351

Article overview

A provenance-preserving register of the peer-reviewed literature Europe PMC indexes for the microbiome, with publication types, journal spread and anchor records that any reader can resolve by DOI.

What this register counts

This page reports how much peer-reviewed literature is indexed on the microbiome, not what that literature concludes. Every headline number comes from a live query against the whole Europe PMC index for the term “microbiome”, restricted to a first publication date between 2020-01-01 and 2026-07-25, and each query is published as a link you can open and re-run. On 2026-07-25 the term resolved to 241,485 records. These are complete counts over the index, not estimates and not a sample. A catalogue count is still a measurement of a catalogue, and a catalogue is not the state of knowledge.

Publication types and access

Publication type comes from the index metadata rather than from any reading of the articles. Of the 241,485 records, the index types 64,413 as a review or meta-analysis and 3,621 as a randomised controlled trial. 166,351 records are flagged open access, which means their full text can be read without payment and a reader can check any statement against the source. Records may carry more than one type, and records with no type assigned are counted in the total but in neither category, so the categories do not sum to the total and were never intended to.

How the literature is distributed

Counts by publication year run 2020: 22,636, 2021: 30,477, 2022: 33,656, 2023: 34,623, 2024: 39,875, 2025: 50,001, 2026: 29,751, with 2025 the heaviest year in the window. Within the 556 records Metatron Health holds in its dated local snapshot of 2026-07-25, the literature spans 281 distinct journals, led by: Scientific reports (24 records), Microbiology spectrum (17 records), Gut microbes (17 records), Microbiome (9 records), Food & function (8 records). That journal breakdown describes the captured snapshot rather than the full index, and is offered as an orientation to where this field publishes, not as a complete ranking.

What this register does not establish

A record count is not evidence of benefit, and being indexed is not endorsement by anyone, including us. This page carries no effect estimate, no comparison between treatments, no dose and no recommendation. A large literature can be large because a question is hard, commercially interesting, or repeatedly studied at low quality, and a captured subset can over-represent whichever records the index returned first. Anyone using this register to decide what to take or which practitioner to see is using it for something it was not built to do.

Anchor records and how to verify them

Each register names anchor records that a reader can resolve independently: Sleep medicine (2026); Journal of ovarian research (2026); Biology of sex differences (2026); Gut microbes (2026). Anchors are selected deterministically, favouring reviews and trials, then open access, then citation count, with one record per journal. Records carrying a retraction or withdrawal notice in the index are excluded. Every anchor carries a DOI, its indexed grant support and its correction state as observed on 2026-07-25. Before this page was published, an independent review lane resolved every source URL listed below and recorded the hash of what it received.

Machine-readable reviewed statements

CLM-EVREG-MICROBIOME-001

The Europe PMC search index reports 241,485 records for the query “"microbiome" AND FIRST_PDATE:[2020-01-01 TO 2026-07-25]”, resolved on 2026-07-25.

Evidence class: bibliographic index count

Sources: SRC-EPMC-INDEX-MICROBIOME

CLM-EVREG-MICROBIOME-002

Of those records, the index types 64,413 as a review or meta-analysis, resolved on 2026-07-25.

Evidence class: bibliographic index count

Sources: SRC-EPMC-REVIEWS-MICROBIOME

CLM-EVREG-MICROBIOME-003

The index types 3,621 of those records as a randomised controlled trial, resolved on 2026-07-25.

Evidence class: bibliographic index count

Sources: SRC-EPMC-TRIALS-MICROBIOME

CLM-EVREG-MICROBIOME-004

166,351 of those records are flagged open access, meaning their full text can be read without payment, resolved on 2026-07-25.

Evidence class: bibliographic index count

Sources: SRC-EPMC-OPENACCESS-MICROBIOME

CLM-EVREG-MICROBIOME-101

Sleep medicine published the record titled “The gut-sleep connection: a scoping review into microbiome alterations in sleep-wake and circadian disorders” in 2026 under DOI 10.1016/j.sleep.2026.109136.

Evidence class: bibliographic record

Sources: SRC-EPMC-MICROBIOME-01

CLM-EVREG-MICROBIOME-102

Journal of ovarian research published the record titled “Targeting the gut microbiome: an integrated probiotic and prebiotic strategy for polycystic ovary syndrome management” in 2026 under DOI 10.1186/s13048-026-02164-0.

Evidence class: bibliographic record

Sources: SRC-EPMC-MICROBIOME-02

CLM-EVREG-MICROBIOME-103

Biology of sex differences published the record titled “Vaginal microbiomes and their pertinent social context: a microbial ecological review proffering AMR-STI acquisition and emergence” in 2026 under DOI 10.1186/s13293-026-00953-2.

Evidence class: bibliographic record

Sources: SRC-EPMC-MICROBIOME-03

CLM-EVREG-MICROBIOME-104

Gut microbes published the record titled “From signals to systems: the epigenetic-microbiome-mitochondrial axis in IBD pathogenesis” in 2026 under DOI 10.1080/19490976.2026.2692755.

Evidence class: bibliographic record

Sources: SRC-EPMC-MICROBIOME-04

Sources and governing contracts

  • SRC-EPMC-INDEX-MICROBIOME — Europe PMC, EMBL-EBI, Europe PMC search index, records of any type: "microbiome" AND FIRST_PDATE:[2020-01-01 TO 2026-07-25]. Role: bibliographic index. Public literature index operated by EMBL-EBI. Metatron Health has no commercial or editorial relationship with the index operator and receives no payment connected to what it indexes. Open source
  • SRC-EPMC-REVIEWS-MICROBIOME — Europe PMC, EMBL-EBI, Europe PMC search index, records typed as a review or meta-analysis: "microbiome" AND FIRST_PDATE:[2020-01-01 TO 2026-07-25] AND PUB_TYPE:"Review". Role: bibliographic index. Public literature index operated by EMBL-EBI. Metatron Health has no commercial or editorial relationship with the index operator and receives no payment connected to what it indexes. Open source
  • SRC-EPMC-TRIALS-MICROBIOME — Europe PMC, EMBL-EBI, Europe PMC search index, records typed as a randomised controlled trial: "microbiome" AND FIRST_PDATE:[2020-01-01 TO 2026-07-25] AND PUB_TYPE:"Randomized Controlled Trial". Role: bibliographic index. Public literature index operated by EMBL-EBI. Metatron Health has no commercial or editorial relationship with the index operator and receives no payment connected to what it indexes. Open source
  • SRC-EPMC-OPENACCESS-MICROBIOME — Europe PMC, EMBL-EBI, Europe PMC search index, records whose full text is free to read: "microbiome" AND FIRST_PDATE:[2020-01-01 TO 2026-07-25] AND OPEN_ACCESS:y. Role: bibliographic index. Public literature index operated by EMBL-EBI. Metatron Health has no commercial or editorial relationship with the index operator and receives no payment connected to what it indexes. Open source
  • SRC-EPMC-MICROBIOME-01 — Sleep medicine, The gut-sleep connection: a scoping review into microbiome alterations in sleep-wake and circadian disorders. Role: independent research. Independent peer-reviewed article. Metatron Health has no financial or editorial relationship with its authors, journal or funders and earns nothing from citing it. Open source
  • SRC-EPMC-MICROBIOME-02 — Journal of ovarian research, Targeting the gut microbiome: an integrated probiotic and prebiotic strategy for polycystic ovary syndrome management. Role: independent research. Independent peer-reviewed article. Metatron Health has no financial or editorial relationship with its authors, journal or funders and earns nothing from citing it. Open source
  • SRC-EPMC-MICROBIOME-03 — Biology of sex differences, Vaginal microbiomes and their pertinent social context: a microbial ecological review proffering AMR-STI acquisition and emergence. Role: independent research. Independent peer-reviewed article. Metatron Health has no financial or editorial relationship with its authors, journal or funders and earns nothing from citing it. Open source
  • SRC-EPMC-MICROBIOME-04 — Gut microbes, From signals to systems: the epigenetic-microbiome-mitochondrial axis in IBD pathogenesis. Role: independent research. Independent peer-reviewed article. Metatron Health has no financial or editorial relationship with its authors, journal or funders and earns nothing from citing it. Open source

Reviewed: 2026-07-25 · Publication: four independent review lanes

Continue your journey

Keep the evidence in context.

Compare the wider literature, check safety boundaries and follow every statement back to its source.