Botanical species · safety record

Acacia nilotica

The EFSA Compendium of Botanicals holds 12 constituent measurements, 3 adverse-effect records and 1 genotoxicity assay for Acacia nilotica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Acacia nilotica (L.) Delile

12Constituent measurements

4Safety records

8Cited sources

38Licensed products (Canada)

Also recorded as

Acacia arabica (Lam.) Willd.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 38 licensed products naming Acacia nilotica as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Fresh

Source material stated

Aged bark
Bark extract
Stem bark

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Gallic acid	Bark	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Proanthocyanidins (condensed tannins)	Aerial part of plants	Solvent extraction	1.4 Gram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Tannins	Aerial part of plants	Solvent extraction	364.8 Gram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Oxalates	Leaves	Solvent extraction	0.481 Percent	—	No resolvable identifier
Proanthocyanidins (condensed tannins)	Leaves	Solvent extraction	55 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Proanthocyanidins (condensed tannins)	Fruit unspecified	Solvent extraction	10 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Saponins	Leaves	Solvent extraction	0.531 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Saponins	Fruit unspecified	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannins	Leaves	Solvent extraction	1.663 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Tannins	Leaves	Solvent extraction	236 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Tannins	Fruit unspecified	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannins	Fruit unspecified	Solvent extraction	163 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	Roots and other underground parts	Solvent extraction	—	Short-term toxicity	No resolvable identifier
Neurotoxicity	Neurologic: central nervous system	Roots and other underground parts	Solvent extraction	—	Short-term toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro	Human (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Arora, S., Brits, E., Kaur, S., Kaur, K., Sohi, RS., Kumar, S., Verschaeve, L. Evaluation or genotoxicity of medicinal plant extracts by the comet and VITOTOX (R) tests . Journal of environmental pathology toxicology and oncology, 2005, vol. 24, no. 3, p. 193-200. DOI
Ehsen, Saman., Qasim, Muhammad., Abideen, Zainul., Rizvi, R. Fatima., Gul, Bilquees., Ansari, Raziuddin., Khan, M. Ajmal. Secondary metabolites as anti-nutritional factors in locally used halophytic forage/fodder.. Pakistan journal of botany, 2016, vol. 48, no. 2, p. 629-636.
Rubanza, CDK., Shem, M., Otsyina, R., Nishino, N., Ichinohe, T., Fujihara, T. Content of phenolics and tannins in leaves and pods of some Acacia and Dichrostachys species and effects on in vitro digestibility. JOURNAL OF ANIMAL AND FEED SCIENCES, 2003, vol. 12, no. 3, p. 645-663.
Hussain, Fahad., Poddar, Saikat Kumar., Ganguly, Amlan., Abdur Rahman, S. M. Investigation of CNS depressant, anti-diarrheal and cytotoxic activities of crude methanolic extracts of Acacia nilotica and Justicia adhatoda root.. Indo american journal of pharmaceutical research, 2016, vol. 6, no. 1, p. 3954-3961.
Alli, Lukman Adewale., Adesokan, Abdulfatai Ayoade., Salawu, Oluwakanyinsola Adeola., Akanji, Musbau Adewunmi. Toxicological studies of aqueous extract of Acacia nilotica root.. Interdisciplinary toxicology, 2015, vol. 8, no. 1, p. 48-54. DOI
Auwal, Mohammed Shaibu., Saka, Sanni., Mairiga, Ismail Alhaji., Sanda, Kyari Abba., Shuaibu, Abdullahi., Ibrahim, Amina. Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extracts of Acacia nilotica (Thorn mimosa). . Veterinary research forum : an international quarterly journal, 2014, vol. 5, no. 2, p. 95-100.
Osuga, Isaac M., Maindi, Catherine N., Abdulrazak, Shaukat A., Nishino, Naoki., Ichinohe, Toshiyoshi., Fujihara, Tsutomu. Potential nutritive value and tannin bioassay of selected Acacia species from Kenya. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2007, vol. 87, no. 8, p. 1533-1538. DOI
Kaur, K., Michael, H., Arora, S., Harkonen, P., Kumar, S. In vitro bioactivity-guided fractionation and characterization of polyphenolic inhibitory fractions from Acacia nilotica (L.) Willd. ex Del. . Journal of ethnopharmacology, 2005, vol. 99, no. 3, p. 353-360. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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