Botanical species · safety record

Aconitum heterophyllum

The EFSA Compendium of Botanicals holds 16 constituent measurements and 1 adverse-effect record for Aconitum heterophyllum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Aconitum heterophyllum Wall. ex Royle

16Constituent measurements
1Safety records
10Cited sources
0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

  • Diterpene alkaloids4
  • Aconitine3
  • Alkaloids3
  • Cardiac glycosides1
  • Diterpene lactones1
  • Hypaconitine1
  • Mesaconitine1
  • Saponins1
  • Tannins1

Plant parts

  • Roots and other underground parts12
  • Live plants4
  • Roots and other underground parts used as staple food1

Preparations

  • Solvent extraction16

Effect types

  • Digestive1

Target tissues

  • Digestive: pancreas1

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
AconitineRoots and other underground partsSolvent extraction11.31 Milligram/kilogramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AlkaloidsRoots and other underground partsSolvent extraction≥ 0.2 PercentHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AlkaloidsRoots and other underground partsSolvent extraction≤ 2.49 PercentHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
Diterpene alkaloidsRoots and other underground partsSolvent extractionLC-MS-MS (QqQ)Resolve DOI
Diterpene alkaloidsRoots and other underground partsSolvent extractionHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
Diterpene alkaloidsRoots and other underground partsSolvent extractionStandard Chromatographic tests (paper- thin layer- and column chromatography)Resolve DOI
Diterpene lactonesRoots and other underground parts used as staple foodUnspecifiedResolve DOI
HypaconitineRoots and other underground partsSolvent extraction13.76 Milligram/kilogramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
MesaconitineRoots and other underground partsSolvent extraction9.68 Milligram/kilogramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AconitineRoots and other underground partsSolvent extraction≤ 0.0018 PercentHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
AconitineRoots and other underground partsSolvent extraction≥ 0.0014 PercentHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
AlkaloidsLive plantsSolvent extractionPhytochemical screeningNo resolvable identifier
Cardiac glycosidesLive plantsSolvent extractionPhytochemical screeningNo resolvable identifier
Diterpene alkaloidsRoots and other underground partsSolvent extractionHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
SaponinsLive plantsSolvent extractionPhytochemical screeningNo resolvable identifier
TanninsLive plantsSolvent extractionPhytochemical screeningNo resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

EffectTarget tissuePlant partPreparationTest organismTest typeSource
DigestiveDigestive: pancreasRoots and other underground partsSolvent extractionIn vitroNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Jabeen, Neelofar., Shakeel-u-Rehman., Bhat, Khursheed A., Khuroo, Mohd .A., Shawl, Abdul S. Quantitative determination of aconitine in Aconitum chasmanthum and Aconitum heterophyllum from Kashmir Himalayas using HPLC.. Journal of pharmacy research, 2011, vol. 4, no. 8, p. 2471-2473.
  2. Ankita Bachhawat, J., Shihabudeen, M.S., Thirumurugan, K. Screening of Fifteen Indian ayurvedic plants for alpha-glucosidase inhibitory activity and enzyme kinetics. International journal of pharmacy and pharmaceutical sciences, 2011, vol. 3, no. SUPPL. 4, p. 267-274.
  3. Singh, K., Saloni, S., Shalini. Phytochemical screening and TLC profiling of different extracts of leaves, roots and stem of Aconitum Heterophyllum a rare medicinal plant of himalayan region. International journal of pharma and bio sciences, 2015, vol. 6, no. 2, p. P194-P200.
  4. Jaiswal, Yogini., Liang, Zhitao., Yong, Peng., Chen, Hubiao., Zhao, Zhongzhen. A comparative study on the traditional Indian Shodhana and Chinese processing methods for aconite roots by characterization and determination of the major components. . Chemistry central journal, 2013, vol. 7, no. 1, p. 169. DOI
  5. Nagarajan, M., Kuruvilla, Gina R., Kumar, K Subrahmanya., Venkatasubramanian, Padma. Abhava pratinidhi dravya: A comparative phytochemistry of Ativisha, Musta and related species. . Journal of ayurveda and integrative medicine, 2015, vol. 6, no. 1, p. 53-63. DOI
  6. Jaiswal, Yogini., Liang, Zhitao., Ho, Alan., Wong, LaiLai., Yong, Peng., Chen, Hubiao., Zhao, Zhongzhen. Distribution of toxic alkaloids in tissues from three herbal medicine Aconitum species using laser micro-dissection, UHPLC-QTOF MS and LC-MS/MS techniques . Phytochemistry, 2014, vol. 107, p. 155-174. DOI
  7. Kumar, Varun., Malhotra, Nikhil., Pal, Tarun., Chauhan, Rajinder Singh. Molecular dissection of pathway components unravel atisine biosynthesis in a non-toxic Aconitum species, A. heterophyllum Wall. . 3 biotech, 2016, vol. 6, no. 1, p. 106-106. DOI
  8. Jacobs, Walter A., Craig, Lyman C. Aconite alkaloids. IX. Isolation of two new alkaloids from Aconitum heterophyllum, heteratisine and hetisine.. Journal of biological chemistry, 1942, vol. 143, p. 605-9.
  9. Malhotra, Nikhil., Kumar, Varun., Sood, Hemant., Singh, Tiratha Raj., Chauhan, Rajinder Singh. Multiple genes of mevalonate and non-mevalonate pathways contribute to high aconites content in an endangered medicinal herb, Aconitum heterophyllum Wall . Phytochemistry, 2014, vol. 108, p. 26-34. DOI
  10. Nisar, Muhammad., Obaidullah., Ahmad, Manzoor., Wadood, Noreen., Lodhi, Muhammad Arif., Shaheen, Farzana., Choudhary, M. Iqbal. New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors . Journal of enzyme inhibition and medicinal chemistry, 2009, vol. 24, no. 1, p. 47-51. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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