Botanical species · safety record
Aconitum heterophyllum
The EFSA Compendium of Botanicals holds 16 constituent measurements and 1 adverse-effect record for Aconitum heterophyllum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Aconitum heterophyllum Wall. ex Royle
Regulatory presence
No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.
What the records describe
Constituents measured
- Diterpene alkaloids4
- Aconitine3
- Alkaloids3
- Cardiac glycosides1
- Diterpene lactones1
- Hypaconitine1
- Mesaconitine1
- Saponins1
- Tannins1
Plant parts
- Roots and other underground parts12
- Live plants4
- Roots and other underground parts used as staple food1
Preparations
- Solvent extraction16
Effect types
- Digestive1
Target tissues
- Digestive: pancreas1
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Aconitine | Roots and other underground parts | Solvent extraction | 11.31 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Alkaloids | Roots and other underground parts | Solvent extraction | ≥ 0.2 Percent | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Alkaloids | Roots and other underground parts | Solvent extraction | ≤ 2.49 Percent | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Diterpene alkaloids | Roots and other underground parts | Solvent extraction | — | LC-MS-MS (QqQ) | Resolve DOI |
| Diterpene alkaloids | Roots and other underground parts | Solvent extraction | — | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Diterpene alkaloids | Roots and other underground parts | Solvent extraction | — | Standard Chromatographic tests (paper- thin layer- and column chromatography) | Resolve DOI |
| Diterpene lactones | Roots and other underground parts used as staple food | — | — | Unspecified | Resolve DOI |
| Hypaconitine | Roots and other underground parts | Solvent extraction | 13.76 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Mesaconitine | Roots and other underground parts | Solvent extraction | 9.68 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Aconitine | Roots and other underground parts | Solvent extraction | ≤ 0.0018 Percent | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Aconitine | Roots and other underground parts | Solvent extraction | ≥ 0.0014 Percent | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Alkaloids | Live plants | Solvent extraction | — | Phytochemical screening | No resolvable identifier |
| Cardiac glycosides | Live plants | Solvent extraction | — | Phytochemical screening | No resolvable identifier |
| Diterpene alkaloids | Roots and other underground parts | Solvent extraction | — | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Saponins | Live plants | Solvent extraction | — | Phytochemical screening | No resolvable identifier |
| Tannins | Live plants | Solvent extraction | — | Phytochemical screening | No resolvable identifier |
Recorded adverse effects
Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.
| Effect | Target tissue | Plant part | Preparation | Test organism | Test type | Source |
|---|---|---|---|---|---|---|
| Digestive | Digestive: pancreas | Roots and other underground parts | Solvent extraction | — | In vitro | No resolvable identifier |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Jabeen, Neelofar., Shakeel-u-Rehman., Bhat, Khursheed A., Khuroo, Mohd .A., Shawl, Abdul S. Quantitative determination of aconitine in Aconitum chasmanthum and Aconitum heterophyllum from Kashmir Himalayas using HPLC.. Journal of pharmacy research, 2011, vol. 4, no. 8, p. 2471-2473.
- Ankita Bachhawat, J., Shihabudeen, M.S., Thirumurugan, K. Screening of Fifteen Indian ayurvedic plants for alpha-glucosidase inhibitory activity and enzyme kinetics. International journal of pharmacy and pharmaceutical sciences, 2011, vol. 3, no. SUPPL. 4, p. 267-274.
- Singh, K., Saloni, S., Shalini. Phytochemical screening and TLC profiling of different extracts of leaves, roots and stem of Aconitum Heterophyllum a rare medicinal plant of himalayan region. International journal of pharma and bio sciences, 2015, vol. 6, no. 2, p. P194-P200.
- Jaiswal, Yogini., Liang, Zhitao., Yong, Peng., Chen, Hubiao., Zhao, Zhongzhen. A comparative study on the traditional Indian Shodhana and Chinese processing methods for aconite roots by characterization and determination of the major components. . Chemistry central journal, 2013, vol. 7, no. 1, p. 169. DOI
- Nagarajan, M., Kuruvilla, Gina R., Kumar, K Subrahmanya., Venkatasubramanian, Padma. Abhava pratinidhi dravya: A comparative phytochemistry of Ativisha, Musta and related species. . Journal of ayurveda and integrative medicine, 2015, vol. 6, no. 1, p. 53-63. DOI
- Jaiswal, Yogini., Liang, Zhitao., Ho, Alan., Wong, LaiLai., Yong, Peng., Chen, Hubiao., Zhao, Zhongzhen. Distribution of toxic alkaloids in tissues from three herbal medicine Aconitum species using laser micro-dissection, UHPLC-QTOF MS and LC-MS/MS techniques . Phytochemistry, 2014, vol. 107, p. 155-174. DOI
- Kumar, Varun., Malhotra, Nikhil., Pal, Tarun., Chauhan, Rajinder Singh. Molecular dissection of pathway components unravel atisine biosynthesis in a non-toxic Aconitum species, A. heterophyllum Wall. . 3 biotech, 2016, vol. 6, no. 1, p. 106-106. DOI
- Jacobs, Walter A., Craig, Lyman C. Aconite alkaloids. IX. Isolation of two new alkaloids from Aconitum heterophyllum, heteratisine and hetisine.. Journal of biological chemistry, 1942, vol. 143, p. 605-9.
- Malhotra, Nikhil., Kumar, Varun., Sood, Hemant., Singh, Tiratha Raj., Chauhan, Rajinder Singh. Multiple genes of mevalonate and non-mevalonate pathways contribute to high aconites content in an endangered medicinal herb, Aconitum heterophyllum Wall . Phytochemistry, 2014, vol. 108, p. 26-34. DOI
- Nisar, Muhammad., Obaidullah., Ahmad, Manzoor., Wadood, Noreen., Lodhi, Muhammad Arif., Shaheen, Farzana., Choudhary, M. Iqbal. New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors . Journal of enzyme inhibition and medicinal chemistry, 2009, vol. 24, no. 1, p. 47-51. DOI
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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