Botanical species · safety record

Actaea racemosa

The EFSA Compendium of Botanicals holds 6 constituent measurements, 8 adverse-effect records and 2 genotoxicity assays for Actaea racemosa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Actaea racemosa L.

6Constituent measurements

10Safety records

9Cited sources

688Licensed products (Canada)

Also recorded as

Cimicifuga racemosa (L.) Nutt.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 688 licensed products naming Actaea racemosa as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid

Source material stated

Actaea racemosa - Rhizome
Actaea racemosa - aerial parts
Actaea racemosa - root
Black Cohosh Root
Dried root and rhizome
Dried root(s)
Dried underground part(s)
Fresh rhizome and adherent roots

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
3,4-dihydroxybenzoic acid	Roots and other underground parts	Solvent extraction	0.00088 Percent	Unspecified	Resolve DOI
Coumarin	Roots and other underground parts used as staple food	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Steroidal triterpene saponins	Roots and other underground parts used as staple food	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Alkaloids	Roots and other underground parts	Solvent extraction	—	Unspecified	No resolvable identifier
Tannins	Roots and other underground parts	Solvent extraction	—	Unspecified	No resolvable identifier
Triterpene saponins	Roots and other underground parts	Solvent extraction	—	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	—	—	—	Not reported	Resolve DOI
Hepatotoxicity	Liver	—	—	House mouse (as animal)	Subchronic	Resolve DOI
Musclo-skeletal	Muscle, skeletal	Roots and other underground parts	Solvent extraction	—	Chronic/long term toxicity	Resolve DOI
Other toxicities	Lung	Roots and other underground parts	Solvent extraction	House mouse (as animal)	Chronic/long term toxicity	Resolve DOI
Other toxicities	Skin/subcutis	Roots and other underground parts	Solvent extraction	—	Not reported	Resolve DOI
Pulmonary and cardiac	Heart	Roots and other underground parts	Solvent extraction	—	Short-term toxicity	Resolve DOI
Hepatotoxicity	Liver	Roots and other underground parts	Solvent extraction	—	Case report	No resolvable identifier
Reproductive	Uterus	Roots and other underground parts	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Ambiguous	gene mutation	mammalian cell gene mutation assay	House mouse (as animal)	With	Resolve DOI
Positive	—	bacterial gene mutation assay	Salmonella typhimurium (as organism)	—	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Seeff, L.B. Herbal Hepatotoxicity. Clinics in liver disease, 2007, vol. 11, no. 3, p. 577-596. DOI
Seifried, H.E., Seifried, R.M., Clarke, J.J., Junghans, T.B., San, R.H.C. A compilation of two decades of mutagenicity test results with the ames Salmonella typhimurium and L5178Y mouse lymphoma cell mutation assays. Chemical research in toxicology, 2006, vol. 19, no. 5, p. 627-644. DOI
Wang, Yun-Jan., Dou, Jinhui., Cross, Kevin P., Valerio, Luis G., Jr. Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms . Regulatory toxicology and pharmacology, 2011, vol. 59, no. 1, p. 111-124. DOI
Abdualmjid, R.J., Sergi, C. Hepatotoxic botanicals - An evidence-based systematic review. Journal of pharmacy and pharmaceutical sciences, 2013, vol. 16, no. 3, p. 376-404.
Moon, Lidiya., Ha, Yu Mi., Jang, Hwa Jin., Kim, Hee Sook., Jun, Min Soo., Kim, Young Min., Lee, Young Soo., Lee, Dong Hwa., Son, Kun Ho., Kim, Hye Jung., Seo, Han Geuk., Lee, Jae Heun., Kim, Yeong Shik., Chang, Ki Churl. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae Rhizome inhibit TNF-alpha-induced VCAM-1 expression in human endothelial cells: Involvement of PPAR-gamma upregulation and PI3K, ERK1/2, and PKC signal pathways . Journal of ethnopharmacology, 2011, vol. 133, no. 2, p. 336-344. DOI
Dos Reis Turolla, M.S., De Souza Nascimento, E. Toxicological information of some herbal medicines used in Brazil Informa��es toxicol�gicas de alguns fitoter�picos utilizados no Brasil . Revista brasileira de ciencias farmaceuticas/brazilian journal of pharmaceutical sciences, 2006, vol. 42, no. 2, p. 289-306.
Dos Reis Turolla, M.S., De Souza Nascimento, E. Toxicological information of some herbal medicines used in Brazil Informações toxicológicas de alguns fitoterápicos utilizados no Brasil . Revista brasileira de ciencias farmaceuticas/brazilian journal of pharmaceutical sciences, 2006, vol. 42, no. 2, p. 289-306.
Davis, Vicki L., Jayo, Manuel J., Ho, Arline., Kotlarczyk, Mary P., Hardy, Mary L., Foster, Warren G., Hughes, Claude L. Black Cohosh Increases Metastatic Mammary Cancer in Transgenic Mice Expressing c-erbB2 . Cancer research, 2008, vol. 68, no. 20, p. 8377-8383. DOI
Di Lorenzo, C., Ceschi, A., Kupferschmidt, H., L�de, S., De Souza Nascimento, E., Dos Santos, A., Colombo, F., Frigerio, G., N�rby, K., Plumb, J., Finglas, P., Restani, P. Adverse effects of plant food supplements and botanical preparations: A systematic review with critical evaluation of causality. British journal of clinical pharmacology, 2015, vol. 79, no. 4, p. 578-592. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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