Botanical species · safety record

Aegle marmelos

The EFSA Compendium of Botanicals holds 47 constituent measurements for Aegle marmelos. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Aegle marmelos (L.) Corrêa

47Constituent measurements
0Safety records
9Cited sources
33Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 33 licensed products naming Aegle marmelos as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

  • Dry

Source material stated

  • Dried fruit
  • Fruit
  • Fruit (standardized extract)
  • Fruit flesh
  • Leaf
  • Root
  • Root extract
  • Stem bark

What the records describe

Constituents measured

  • Coumarins8
  • Psoralen7
  • Aegeline6
  • Imperatorin6
  • Umbelliferone5
  • Angelicin4
  • Scopoletin2
  • Skimmianine2
  • Auraptene1
  • Brassinosteroids1

Plant parts

  • Bark20
  • Fruit unspecified14
  • Roots and other underground parts7
  • Leaves5
  • Unspecified1

Preparations

  • Solvent extraction46

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
AegelineBarkSolvent extraction0.003 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AegelineFruit unspecifiedSolvent extraction≥ 0.004 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AegelineFruit unspecifiedSolvent extraction≤ 0.158 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AegelineLeavesSolvent extraction≥ 1.26 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AegelineLeavesSolvent extraction≤ 4.13 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AegelineRoots and other underground partsSolvent extraction0.035 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AngelicinRoots and other underground partsSolvent extraction2.51 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AngelicinFruit unspecifiedSolvent extraction≤ 0.27 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AngelicinFruit unspecifiedSolvent extraction≥ 5e-04 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AngelicinBarkSolvent extraction0.095 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
AurapteneBarkSolvent extractionChromatographic testsResolve DOI
BrassinosteroidsLeavesSolvent extractionStandard Chromatographic tests (paper- thin layer- and column chromatography)Resolve DOI
CoumarinsBarkSolvent extractionChromatographic testsResolve DOI
CoumarinsBarkSolvent extractionChromatographic testsResolve DOI
CoumarinsBarkSolvent extraction0.11 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
CoumarinsFruit unspecifiedSolvent extraction≥ 0.007 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
CoumarinsBarkSolvent extraction≤ 1.18 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)Resolve DOI
CoumarinsBarkSolvent extraction≥ 0.623 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)Resolve DOI
CoumarinsRoots and other underground partsSolvent extraction0.012 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
CoumarinsFruit unspecifiedSolvent extraction≤ 0.099 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
EugenolFruit unspecifiedSolvent extraction0.0157 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)Resolve DOI
Furoquinoline alkaloidsLeavesSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
ImperatorinBarkSolvent extraction≥ 0.084 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)Resolve DOI
ImperatorinBarkSolvent extraction≤ 0.294 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)Resolve DOI
ImperatorinBarkSolvent extraction0.007 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
ImperatorinFruit unspecifiedSolvent extraction≥ 0.34 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
ImperatorinFruit unspecifiedSolvent extraction≤ 10.67 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
ImperatorinRoots and other underground partsSolvent extraction2.04 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
PeriplogeninLeavesSolvent extractionStandard Chromatographic tests (paper- thin layer- and column chromatography)Resolve DOI
PsoralenFruit unspecifiedSolvent extraction0.0047 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)Resolve DOI
PsoralenBarkSolvent extraction0.011 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
PsoralenFruit unspecifiedSolvent extraction≥ 0.005 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
PsoralenFruit unspecifiedSolvent extraction≤ 0.096 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
PsoralenRoots and other underground partsSolvent extraction0.006 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
PsoralenBarkSolvent extraction≥ 0.046 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)Resolve DOI
PsoralenBarkSolvent extraction≤ 0.071 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)Resolve DOI
ScopoletinBarkSolvent extraction0.097 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
ScopoletinRoots and other underground partsSolvent extraction0.018 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
SkimmianineBarkSolvent extraction≤ 0.347 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)Resolve DOI
SkimmianineBarkSolvent extraction≥ 0.088 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)Resolve DOI

40 of 47 records are shown, ordered so that records carrying a resolvable reference come first.

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Dhalwal, K., Shinde, VM., Mahadik, KR., Namdeo, AG. Rapid densitometric method for simultaneous analysis of umbelliferone, psoralen, and eugenol in herbal raw materials using HPTLC. JOURNAL OF SEPARATION SCIENCE, 2007, vol. 30, no. 13, p. 2053-2058. DOI
  2. Li, Jun., Mahdi, Fakhri., Du, Lin., Jekabsons, Mika B., Zhou, Yu-Dong., Nagle, Dale G. Semisynthetic studies identify mitochondria poisons from botanical dietary supplements-Geranyloxycoumarins from Aegle marmelos . Bioorganic & medicinal chemistry, 2013, vol. 21, no. 7, p. 1795-1803. DOI
  3. Avula, Bharathi., Chittiboyina, Amar G., Wang, Yan-Hong., Sagi, Satyanarayanaraju., Raman, Vijayasankar., Wang, Mei., Khan, Ikhlas A. Simultaneous Determination of Aegeline and Six Coumarins from Different Parts of the Plant Aegle marmelos Using UHPLC-PDA-MS and Chiral Separation of Aegeline Enantiomers Using HPLC-ToF-MS . Planta medica, 2016, vol. 82, no. 6, p. 580-588. DOI
  4. Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. Xanthotoxol (HMDB29457).. Human metabolome database, 2012, vol. 3.0.
  5. Gajbhiye, Narendra A., Makasana, Jayanti., Thorat, Trishul. Simultaneous Determination of Marmin, Skimmianine, Umbelliferone, Psoralene, and Imperatorin in the Root Bark of Aegle marmelos by High-Performance Thin-Layer Chromatography . Jpc-journal of planar chromatography-modern tlc, 2012, vol. 25, no. 4, p. 306-313. DOI
  6. Sondhi, Nishi., Bhardwaj, Renu., Kaur, Satwinderjeet., Kumar, Neeraj., Singh, Bikram. Isolation of 24-epibrassinolide from leaves of Aegle marmelos and evaluation of its antigenotoxicity employing Allium cepa chromosomal aberration assay . Plant growth regulation, 2008, vol. 54, no. 3, p. 217-224. DOI
  7. Mohammed, Magdy M. D., Ibrahim, Nabaweya A., El-Sakhawy, Fatma S., Mohamed, Khaled M., Deabes, Doaa A. -H. Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa . Natural product research, 2016, vol. 30, no. 22, p. 2559-2566. DOI
  8. Radchatawedchakoon, Widchaya., Bamrungsuk, Suthep., Namwijit, Siriporn., Apiratikul, Nuttapon., Sakee, Uthai., Yingyongnarongkul, Boon-ek. A New 3 '-Prenyloxypsoralen from the Raw Fruits of Aegle marmelos and its Cytotoxic Activity . Natural product communications, 2015, vol. 10, no. 11, p. 1973-1975.
  9. Panda, Sunanda., Kar, Anand. Periplogenin-3-O- -D-Glucopyranosyl -(1 -> 6)- -D-Glucopyaranosyl- -(1 -> 4) -D-Cymaropyranoside, Isolated from Aegle marmelos Protects Doxorubicin Induced Cardiovascular Problems and Hepatotoxicity in Rats . Cardiovascular therapeutics, 2009, vol. 27, no. 2, p. 108-116. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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