Botanical species · safety record
Aegle marmelos
The EFSA Compendium of Botanicals holds 47 constituent measurements for Aegle marmelos. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Aegle marmelos (L.) Corrêa
Regulatory presence
Health Canada's Licensed Natural Health Products Database holds 33 licensed products naming Aegle marmelos as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.
Extract types on licence
Source material stated
What the records describe
Constituents measured
- Coumarins8
- Psoralen7
- Aegeline6
- Imperatorin6
- Umbelliferone5
- Angelicin4
- Scopoletin2
- Skimmianine2
- Auraptene1
- Brassinosteroids1
Plant parts
- Bark20
- Fruit unspecified14
- Roots and other underground parts7
- Leaves5
- Unspecified1
Preparations
- Solvent extraction46
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Aegeline | Bark | Solvent extraction | 0.003 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Aegeline | Fruit unspecified | Solvent extraction | ≥ 0.004 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Aegeline | Fruit unspecified | Solvent extraction | ≤ 0.158 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Aegeline | Leaves | Solvent extraction | ≥ 1.26 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Aegeline | Leaves | Solvent extraction | ≤ 4.13 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Aegeline | Roots and other underground parts | Solvent extraction | 0.035 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Angelicin | Roots and other underground parts | Solvent extraction | 2.51 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Angelicin | Fruit unspecified | Solvent extraction | ≤ 0.27 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Angelicin | Fruit unspecified | Solvent extraction | ≥ 5e-04 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Angelicin | Bark | Solvent extraction | 0.095 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Auraptene | Bark | Solvent extraction | — | Chromatographic tests | Resolve DOI |
| Brassinosteroids | Leaves | Solvent extraction | — | Standard Chromatographic tests (paper- thin layer- and column chromatography) | Resolve DOI |
| Coumarins | Bark | Solvent extraction | — | Chromatographic tests | Resolve DOI |
| Coumarins | Bark | Solvent extraction | — | Chromatographic tests | Resolve DOI |
| Coumarins | Bark | Solvent extraction | 0.11 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Coumarins | Fruit unspecified | Solvent extraction | ≥ 0.007 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Coumarins | Bark | Solvent extraction | ≤ 1.18 Percent | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Coumarins | Bark | Solvent extraction | ≥ 0.623 Percent | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Coumarins | Roots and other underground parts | Solvent extraction | 0.012 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Coumarins | Fruit unspecified | Solvent extraction | ≤ 0.099 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Eugenol | Fruit unspecified | Solvent extraction | 0.0157 Percent | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Furoquinoline alkaloids | Leaves | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Imperatorin | Bark | Solvent extraction | ≥ 0.084 Percent | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Imperatorin | Bark | Solvent extraction | ≤ 0.294 Percent | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Imperatorin | Bark | Solvent extraction | 0.007 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Imperatorin | Fruit unspecified | Solvent extraction | ≥ 0.34 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Imperatorin | Fruit unspecified | Solvent extraction | ≤ 10.67 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Imperatorin | Roots and other underground parts | Solvent extraction | 2.04 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Periplogenin | Leaves | Solvent extraction | — | Standard Chromatographic tests (paper- thin layer- and column chromatography) | Resolve DOI |
| Psoralen | Fruit unspecified | Solvent extraction | 0.0047 Percent | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Psoralen | Bark | Solvent extraction | 0.011 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Psoralen | Fruit unspecified | Solvent extraction | ≥ 0.005 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Psoralen | Fruit unspecified | Solvent extraction | ≤ 0.096 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Psoralen | Roots and other underground parts | Solvent extraction | 0.006 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Psoralen | Bark | Solvent extraction | ≥ 0.046 Percent | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Psoralen | Bark | Solvent extraction | ≤ 0.071 Percent | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Scopoletin | Bark | Solvent extraction | 0.097 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Scopoletin | Roots and other underground parts | Solvent extraction | 0.018 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Skimmianine | Bark | Solvent extraction | ≤ 0.347 Percent | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Skimmianine | Bark | Solvent extraction | ≥ 0.088 Percent | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
40 of 47 records are shown, ordered so that records carrying a resolvable reference come first.
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Dhalwal, K., Shinde, VM., Mahadik, KR., Namdeo, AG. Rapid densitometric method for simultaneous analysis of umbelliferone, psoralen, and eugenol in herbal raw materials using HPTLC. JOURNAL OF SEPARATION SCIENCE, 2007, vol. 30, no. 13, p. 2053-2058. DOI
- Li, Jun., Mahdi, Fakhri., Du, Lin., Jekabsons, Mika B., Zhou, Yu-Dong., Nagle, Dale G. Semisynthetic studies identify mitochondria poisons from botanical dietary supplements-Geranyloxycoumarins from Aegle marmelos . Bioorganic & medicinal chemistry, 2013, vol. 21, no. 7, p. 1795-1803. DOI
- Avula, Bharathi., Chittiboyina, Amar G., Wang, Yan-Hong., Sagi, Satyanarayanaraju., Raman, Vijayasankar., Wang, Mei., Khan, Ikhlas A. Simultaneous Determination of Aegeline and Six Coumarins from Different Parts of the Plant Aegle marmelos Using UHPLC-PDA-MS and Chiral Separation of Aegeline Enantiomers Using HPLC-ToF-MS . Planta medica, 2016, vol. 82, no. 6, p. 580-588. DOI
- Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. Xanthotoxol (HMDB29457).. Human metabolome database, 2012, vol. 3.0.
- Gajbhiye, Narendra A., Makasana, Jayanti., Thorat, Trishul. Simultaneous Determination of Marmin, Skimmianine, Umbelliferone, Psoralene, and Imperatorin in the Root Bark of Aegle marmelos by High-Performance Thin-Layer Chromatography . Jpc-journal of planar chromatography-modern tlc, 2012, vol. 25, no. 4, p. 306-313. DOI
- Sondhi, Nishi., Bhardwaj, Renu., Kaur, Satwinderjeet., Kumar, Neeraj., Singh, Bikram. Isolation of 24-epibrassinolide from leaves of Aegle marmelos and evaluation of its antigenotoxicity employing Allium cepa chromosomal aberration assay . Plant growth regulation, 2008, vol. 54, no. 3, p. 217-224. DOI
- Mohammed, Magdy M. D., Ibrahim, Nabaweya A., El-Sakhawy, Fatma S., Mohamed, Khaled M., Deabes, Doaa A. -H. Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa . Natural product research, 2016, vol. 30, no. 22, p. 2559-2566. DOI
- Radchatawedchakoon, Widchaya., Bamrungsuk, Suthep., Namwijit, Siriporn., Apiratikul, Nuttapon., Sakee, Uthai., Yingyongnarongkul, Boon-ek. A New 3 '-Prenyloxypsoralen from the Raw Fruits of Aegle marmelos and its Cytotoxic Activity . Natural product communications, 2015, vol. 10, no. 11, p. 1973-1975.
- Panda, Sunanda., Kar, Anand. Periplogenin-3-O- -D-Glucopyranosyl -(1 -> 6)- -D-Glucopyaranosyl- -(1 -> 4) -D-Cymaropyranoside, Isolated from Aegle marmelos Protects Doxorubicin Induced Cardiovascular Problems and Hepatotoxicity in Rats . Cardiovascular therapeutics, 2009, vol. 27, no. 2, p. 108-116. DOI
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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