Botanical species · safety record

Ageratina altissima

The EFSA Compendium of Botanicals holds 15 constituent measurements and 10 adverse-effect records for Ageratina altissima. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Ageratina altissima (L.) R.M.King & H.Rob.

15Constituent measurements

10Safety records

6Cited sources

0Licensed products (Canada)

Also recorded as

Eupatorium rugosum Houtt.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
3-oxyangeloyl-tremetone	Aerial part of plants	Solvent extraction	≥ 0.0404 Milligram/gram	GC-MS	Resolve DOI
3-oxyangeloyl-tremetone	Aerial part of plants	Solvent extraction	≤ 0.0481 Milligram/gram	GC-MS	Resolve DOI
Benzofurans	Aerial part of plants	Drying (dehydration)	≥ 0.15 Percent	HPLC with standard detection methods	Resolve DOI
Benzofurans	Aerial part of plants	Drying (dehydration)	≤ 6.73 Percent	HPLC with standard detection methods	Resolve DOI
Benzofurans	Aerial part of plants	Drying (dehydration)	≥ 0.253 Percent	HPLC with standard detection methods	Resolve DOI
Benzofurans	Aerial part of plants	Drying (dehydration)	≤ 4.6 Percent	HPLC with standard detection methods	Resolve DOI
Dehydrotremetone	Aerial part of plants	Solvent extraction	≤ 2.78 Milligram/gram	GC-MS	Resolve DOI
Dehydrotremetone	Aerial part of plants	Solvent extraction	≥ 0.212 Milligram/gram	GC-MS	Resolve DOI
Dehydrotremetone	Aerial part of plants	Drying (dehydration)	≤ 0.78 Percent	HPLC with standard detection methods	Resolve DOI
Dehydrotremetone	Aerial part of plants	Drying (dehydration)	≥ 0.033 Percent	HPLC with standard detection methods	Resolve DOI
Tremetone	Aerial part of plants	Fresh	—	Gaschromatography (GC)	Resolve DOI
Tremetone	Aerial part of plants	Solvent extraction	≤ 6.5 Milligram/gram	GC-MS	Resolve DOI
Tremetone	Aerial part of plants	Solvent extraction	≥ 0.383 Milligram/gram	GC-MS	Resolve DOI
Tremetone	Aerial part of plants	Drying (dehydration)	≤ 3.5 Percent	HPLC with standard detection methods	Resolve DOI
Tremetone	Aerial part of plants	Drying (dehydration)	≥ 0.004 Percent	HPLC with standard detection methods	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Liver	Aerial part of plants	Drying (dehydration)	Goat (as animal)	Short-term toxicity	Resolve DOI
Musclo-skeletal	Muscle, skeletal	Leaves	Drying (dehydration)	Goat (as animal)	Short-term toxicity	Resolve DOI
Musclo-skeletal	Muscle, skeletal	Aerial part of plants	Drying (dehydration)	Goat (as animal)	Short-term toxicity	Resolve DOI
Musclo-skeletal	Muscle, skeletal	Aerial part of plants	Fresh	Cattle (as animal)	Case report	Resolve DOI
Musclo-skeletal	Heart	Aerial part of plants	—	—	Case report	Resolve DOI
Pulmonary and cardiac	Digestive	—	—	Cattle (as animal)	Case report	No resolvable identifier
Pulmonary and cardiac	Digestive	—	—	Gallus gallus (chicken) (as animal)	Case report	No resolvable identifier
Pulmonary and cardiac	Digestive	—	—	Horse (as animal)	Case report	No resolvable identifier
Pulmonary and cardiac	Digestive	—	—	Goat (as animal)	Case report	No resolvable identifier
Pulmonary and cardiac	Digestive	—	—	Sheep (as animal)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Davis, T. Z., Stegelmeier, B. L., Lee, S. T., Collett, M. G., Green, B. T., Pfister, J. A., Evans, T. J., Grum, D. S., Buck, S. White snakeroot poisoning in goats: Variations in toxicity with different plant chemotypes . Research in veterinary science, 2016, vol. 106, p. 29-36. DOI
Finno, Carrie J., Valberg, Stephanie J., Wunschmann, Arno., Murphy, Michael J. Seasonal pasture myopathy in horses in the midwestern United States: 14 cases (1998-2005) . Javma-journal of the american veterinary medical association, 2006, vol. 229, no. 7, p. 1134-1141. DOI
Lee, Stephen T., Davis, T. Zane., Cook, Daniel., Stegelmeier, Bryan L. Evaluation of Drying Methods and Toxicity of Rayless Goldenrod (Isocoma pluriflora) and White Snakeroot (Ageratina altissima) in Goats . Journal of agricultural and food chemistry, 2012, vol. 60, no. 19, p. 4849-4853. DOI
Sharma, Om P., Dawra, Rajinder K., Kurade, Nitin P., Sharma, Pritam D. A review of the toxicosis and biological properties of the genus Eupatorium . Natural toxins, 1998, vol. 6, no. 1, p. 1-14.
Lee, Stephen T., Davis, T. Zane., Gardner, Dale R., Stegelmeier, Bryan L., Evans, Tim J. Quantitative Method for the Measurement of Three Benzofuran Ketones in Rayless Goldenrod (Isocoma pluriflora) and White Snakeroot (Ageratina altissima) by High-Performance Liquid Chromatography (HPLC) . Journal of agricultural and food chemistry, 2009, vol. 57, no. 12, p. 5639-5643. DOI
Meyerholtz, Kimberly A., Burcham, Grant N., Miller, Margaret A., Wilson, Christina R., Hooser, Stephen B., Lee, Stephen T. Development of a gas chromatography-mass spectrometry technique to diagnose white snakeroot (Ageratina altissima) poisoning in a cow . Journal of veterinary diagnostic investigation, 2011, vol. 23, no. 4, p. 775-779. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature