Botanical species · safety record

Ailanthus altissima

The EFSA Compendium of Botanicals holds 9 constituent measurements and 2 adverse-effect records for Ailanthus altissima. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Ailanthus altissima (Mill.) Swingle

9Constituent measurements

2Safety records

7Cited sources

38Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 38 licensed products naming Ailanthus altissima as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
decoction

Source material stated

Bark
Dried root-bark
Fresh flowering shoots and fresh bark from the trunk and branches
Root
Root bark
Stem bark

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Carboline alkaloids	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Carboline alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Quassinoids	Live plants	—	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Quassinoids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Canthin-6-one	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Indole alkaloids	—	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Lignans	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Palmatine	—	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Scopoletin	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Reproductive	Uterus	Bark	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Roots and other underground parts	Solvent extraction	Rat (as animal)	Not reported	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Peduto, A., Filosa, R., De Caprariis, P., De Feo, V., Li, S., Wang, P., De Martino, L. 1-methoxy-canthin-6-one and related beta-carbolines: From natural compound to synthesis and biological activities. Studies in natural products chemistry, 2012, vol. 38, p. 81-104. DOI
Kim, Hye Mi., Sezirahiga, Jurdas., Choi, Jung-Hye., Jang, Dae Sik., Lee, Jin Su., Jeong, Miran., Choi, Jung-Hye., Jang, Dae Sik., Kwon, Jaeyoung., Lee, Dongho. A New Canthinone-Type Alkaloid Isolated from Ailanthus altissima Swingle. Molecules (basel, switzerland), 2016, vol. 21, no. 5.
Mani, M., Rathore, D.S. Pharmacological evaluation of anti-fertility effect of stem bark of ailanthus Altissima in wistar albino rats. Research journal of pharmacy and technology, 2016, vol. 9, no. 5, p. 497-500. DOI
Kim, J., Kim, H., Park, S.W., Choi, J.-W., Lee, C.K. Studies on the biologic activities of the constituents of Ailanthi Cortex Radicis (II) - Acute and renal toxicity of chloroform fraction. Korean journal of pharmacognosy, 1994, vol. 25, no. 2, p. 140-143.
Mo, Xiao-yu., Mai, Jing-biao. Chemical constituents of ethyl acetate extract from Ailanthus altissima.. Zhongguo shiyan fangjixue zazhi, 2013, vol. 19, no. 16, p. 136-138.
De Feo, V., De Martino, L., Quaranta, E., Pizza, C. Isolation of phytotoxic compounds from tree-of-heaven (Ailanthus altissima Swingle) . Journal of agricultural and food chemistry, 2003, vol. 51, no. 5, p. 1177-1180. DOI
Heisey, RM. Identification of an allelopathic compound from Ailanthus altissima (Simaroubaceae) and characterization of its herbicidal activity . American journal of botany, 1996, vol. 83, no. 2, p. 192-200. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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