Botanical species · safety record

Akebia trifoliata

The EFSA Compendium of Botanicals holds 1 constituent measurement and 1 adverse-effect record for Akebia trifoliata. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Akebia trifoliata (Thunb.) Koidz.

1Constituent measurements

1Safety records

2Cited sources

36Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 36 licensed products naming Akebia trifoliata as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Akebia trifoliata - Stem
Flower
Fruit
Rhizome
Root
Seed
Stem
Stem bark - inner

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Pentacyclic triterpene saponins	Stem / stalk	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital: kidneys	Stem / stalk	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Mimaki, Y., Kuroda, M., Yokosuka, A., Harada, H., Fukushima, M., Sashida, Y. Triterpenes and triterpene saponins from the stems of Akebia trifoliata. Chemical & pharmaceutical bulletin, 2003, vol. 51, no. 8, p. 960-965.
Xue, Xiang., Xiao, Ying., Gong, Likun., Guan, Shuhong., Liu, Yongzhen., Lu, Henglei., Qi, Xinming., Zhang, Yunhai., Li, Yan., Wua, Xiongfei., Ren, Jin. Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice. JOURNAL OF ETHNOPHARMACOLOGY, 2008, vol. 119, no. 1, p. 87-93. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature