Botanical species · safety record

Allamanda cathartica

The EFSA Compendium of Botanicals holds 6 constituent measurements, 5 adverse-effect records and 1 genotoxicity assay for Allamanda cathartica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Allamanda cathartica L.

6Constituent measurements

6Safety records

9Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-cineole	Flower	Essential oil	12.6 Percent	GC-MS	Resolve DOI
Alkaloids	Bark	Powder	—	—	Resolve DOI
Calcium oxalate	Bark	Powder	—	—	Resolve DOI
Cardiac glycosides	Bark	Powder	—	—	Resolve DOI
Myrcene	Flower	Essential oil	2.9 Percent	GC-MS	Resolve DOI
Sesquiterpene lactones	Live plants	Solvent extraction	—	GC-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Leaves	Solvent extraction	House mouse (as animal)	Case report	Resolve DOI
Digestive	Digestive	Leaves	Solvent extraction	Rat (as animal)	Case report	Resolve DOI
Reproductive	Testes	Leaves	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Testes	Leaves	Solvent extraction	House mouse (as animal)	Reproduction toxicity	No resolvable identifier
Not stated	Digestive	Unspecified	—	Cattle (as animal)	Other	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Other	No data	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Baez, Disnelys., Pino, Jorge A., Morales, Diego. Scent Composition from Flowers of Allamanda cathartica L. from Cuba. Journal of essential oil bearing plants, 2012, vol. 15, no. 1, p. 12-14. DOI
Chaveerach, Arunrat., Tanee, Tawatchai., Patarapadungkit, Natcha., Khamwachirapithak, Peerapat., Sudmoon, Runglawan. Cytotoxicity and genotoxicity of Allamanda and Plumeria species. Scienceasia, 2016, vol. 42, no. 6, p. 375-381. DOI
Chaveerach, Arunrat., Aungkapattamagul, Sarocha., Tanee, Tawatchai., Noikotr, Kowit., Sudmoon, Runglawan. Genetic verification and chemical contents identification of Allamanda species (Apocynaceae) . Pakistan journal of pharmaceutical sciences, 2014, vol. 27, no. 3, p. 417-424.
Singh, A., Singh, S. K. Reversible antifertility effect of aqueous leaf extract of Allamanda cathartica L. in male laboratory mice . Andrologia, 2008, vol. 40, no. 6, p. 337-345. DOI
Nguyen, Phuong Q. T., Luu, Thuy T., Bai, Yang., Nguyen, Giang K. T., Pervushin, Konstantin., Tam, James P. Allotides: Proline-Rich Cystine Knot alpha-Amylase Inhibitors from Allamanda cathartica . Journal of natural products, 2015, vol. 78, no. 4, p. 695-704. DOI
Akah, P.A., Offiah, V.N. Gastrointestinal effects of allamanda cathartica leaf extracts. Pharmaceutical biology, 1992, vol. 30, no. 3, p. 213-217. DOI
Singh, Akanksha., Singh, Shio Kumar. Reversible antifertility effect of aqueous leaf extract of allamanda cathartica L. in male mice . Journal of andrology, 2007, p. 68-69.
Tokarnia, Carlos Hubinger., Armien, Anibal Guillemo., Peixoto, Paul Vargas., Barbosa, Jose Diomedes., Brito, Marilene De Farias., Dobereiner, Jurgen. Experiments on the toxicity of some ornamental plants in cattle. Pesquisa veterinaria brasileira, 1996, vol. 16, no. 1, p. 5-20.
Datta, S.K., Datta, P.C. Pharmacognosy of allamanda bark drugs. Pharmaceutical biology, 1982, vol. 20, no. 1, p. 43-52. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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