Botanical species · safety record

Aloe ferox

The EFSA Compendium of Botanicals holds 21 constituent measurements and 1 genotoxicity assay for Aloe ferox. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Aloe ferox Mill.

21Constituent measurements

1Safety records

6Cited sources

59Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 59 licensed products naming Aloe ferox as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Aloe ferox - Leaf
Aloe vera - leaf gel
Concentrated dried juice
Dried juice
Inspissated juice
Latex
Leaf
Leaf gel

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Aloe-emodin	Leaves	Solvent extraction	0.2 Microgram/millilitre	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aloin a	Leaves	Solvent extraction	0.5 Microgram/millilitre	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aloin a	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aloin b	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aloinoside a	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aloinoside b	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Anthraquinones	—	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Benzofurans	—	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
5-hydroxyaloin	Leaves	Drying (dehydration)	13.7 Milligram/gram	Classification not possible	No resolvable identifier
Aloe-emodin	Leaves	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Aloeresin a	Leaves	Drying (dehydration)	86.3 Milligram/gram	Classification not possible	No resolvable identifier
Aloeresin c	Leaves	Drying (dehydration)	7 Milligram/gram	Classification not possible	No resolvable identifier
Aloin a	Leaves	Drying (dehydration)	50.7 Milligram/gram	Classification not possible	No resolvable identifier
Aloin a	Leaves	Drying (dehydration)	0.7 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aloin a	Leaves	Drying (dehydration)	0.4 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aloin b	Leaves	Drying (dehydration)	25.3 Milligram/gram	Classification not possible	No resolvable identifier
Aloin b	Leaves	Drying (dehydration)	0.6 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aloinoside a	Leaves	Drying (dehydration)	10.3 Milligram/gram	Classification not possible	No resolvable identifier
Aloinoside a	Leaves	Drying (dehydration)	0.5 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aloinoside b	Leaves	Drying (dehydration)	0.5 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aloinoside b	Leaves	Drying (dehydration)	9 Milligram/gram	Classification not possible	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	—	Bacillus subtilis recombination assay	Bacillus subtilis (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Chiang, Hsiu-Mei., Lin, Ya-Tze., Hsiao, Pei-Ling., Su, Yu-Han., Tsao, Hui-Ting., Wen, Kuo-Ching. Determination of Marked Components -aloin and aloe-emodin- in Aloe vera before and after hydrolysis . Journal of food and drug analysis, 2012, vol. 20, no. 3, p. 646-652. DOI
[Anonymous]. Final report on the safety assessment of Aloe Andongensis Extract, Aloe Andongensis Leaf Juice, Aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice, Aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract . International journal of toxicology, 2007, vol. 26, p. 1-50. DOI
Adhami, Hamid-Reza., Viljoen, Alvaro M. Preparative isolation of bio-markers from the leaf exudate of Aloe ferox (aloe bitters'') by high performance counter-current chromatography . Phytochemistry letters, 2015, vol. 11, p. 321-325.
Kiridena, W., Poole, SK., Miller, KG., Poole, CF. Determination of aloin and aloe-emodin in aloe consumable products by thin layer chromatography . Jpc-journal of planar chromatography-modern tlc, 1995, vol. 8, no. 6, p. 416-419.
RAUWALD, HW., BEIL, A. 5-HYDROXYALOIN-A IN THE GENUS ALOE - THIN-LAYER CHROMATOGRAPHIC SCREENING AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION . Zeitschrift fur naturforschung c-a journal of biosciences, 1993, vol. 48, no. 1-2, p. 1-4.
KOYAMA, J., OGURA, T., TAGAHARA, K. NAPHTHO 2,3-C FURAN-4,9-DIONE AND ITS DERIVATIVES FROM ALOE FEROX. Phytochemistry, 1994, vol. 37, no. 4, p. 1147-1148. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature