Botanical species · safety record

Aloe vera

The EFSA Compendium of Botanicals holds 2 constituent measurements, 9 adverse-effect records and 6 genotoxicity assays for Aloe vera. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Aloe vera (L.) Burm.f.

2Constituent measurements

15Safety records

6Cited sources

1,023Licensed products (Canada)

Also recorded as

Aloe barbadensis Mill.
Aloe vulgaris Lam.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1,023 licensed products naming Aloe vera as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid

Source material stated

Aloe barbadensis leaf gel
Aloe vera
Aloe vera - Latex
Aloe vera - Leaf
Aloe vera - leaf gel
Bark
Dried latex
Dried latex drawn from aloe leaves

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Anthraquinones	Leaves	Solvent extraction	—	Unspecified	Resolve DOI
Anthrones	Leaves	Solvent extraction	—	Unspecified	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Leaves	—	Human (as organism)	Case report	Resolve DOI
Immunotoxicity	Cardiovascular / haematological: lymph nodes	Leaves	Powder	Rat (as animal)	Subchronic	Resolve DOI
Immunotoxicity	Cardiovascular / haematological: lymph nodes	Leaves	Powder	Rat (as animal)	Subchronic	Resolve DOI
Other toxicities	Digestive	Live plants	Solvent extraction	House mouse (as animal)	Chronic/long term toxicity	Resolve DOI
Other toxicities	Digestive	Leaves	Solvent extraction	Rat (as animal)	Chronic/long term toxicity	Resolve DOI
Other toxicities	Digestive	Leaves	Solvent extraction	Rat (as animal)	Chronic/long term toxicity	Resolve DOI
Other toxicities	Digestive	Live plants	Solvent extraction	House mouse (as animal)	Chronic/long term toxicity	Resolve DOI
Reproductive	Testes	Leaves	Powder	Rat (as animal)	Reproduction toxicity	Resolve DOI
Other toxicities	—	Leaves	Solvent extraction	House mouse (as animal)	Acute toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	in vitro mammalian chromosome aberration test	Human (as organism)	—	Resolve DOI
Positive	DNA damage and/or repair	bacterial reverse mutation assay	Escherichia coli (as organism)	—	Resolve DOI
Positive	DNA damage and/or repair	in vitro mammalian cell micronucleus test	Human (as organism)	—	Resolve DOI
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	House mouse (as animal)	—	Resolve DOI
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	—	Resolve DOI
Positive	DNA damage and/or repair	micronucleus assay	House mouse (as animal)	No data	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Wan, Jin-zhi., Xu, Xin-jun., Luo, Xuan., Fang, Wei., Fang, Zi-sheng. The genotoxicity of the aloe extract primarily evaluated by micronucleus test. Zhongguo xinyao zazhi, 2008, p. 931-933.
Zhang, Z., Mei, N., Chen, S., Guo, L., Guo, X. Assessment of Genotoxic Effects of Selected Herbal Dietary Supplements. Nutraceuticals: efficacy, safety and toxicity, 2016, p. 883-892. DOI
Kayraldiz, Ahmet., Kocaman, Ayse Yavuz., Rencuzogullari, Eyyup., Istifli, Erman Salih., Ila, Hasan Basri., Topaktas, Mehmet., Daglioglu, Yusuf Kenan. The genotoxic and antigenotoxic effects of Aloe vera leaf extract in vivo and in vitro . Turkish journal of biology, 2010, vol. 34, no. 3, p. 235-246. DOI
Paes-Leme, AA., Motta, ES., De Mattos, JCP., Dantas, FJS., Bezerra, RJAC., Caldeira-De-Araujo, A. Assessment of Aloe vera (L.) genotoxic potential on Escherichia coli and plasmid DNA . Journal of ethnopharmacology, 2005, vol. 102, no. 2, p. 197-201. DOI
Guo, X., Mei, N. Aloe vera: A review of toxicity and adverse clinical effects. Journal of environmental science and health - part c environmental carcinogenesis and ecotoxicology reviews, 2016, vol. 34, no. 2, p. 77-96. DOI
Logarto Parra, A., Silva Yhebra, R., Guerra Sardinas, I., Iglesias Buela, L. Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. . Phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, vol. 8, no. 5, p. 395-400.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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