Botanical species · safety record

Ammi majus

The EFSA Compendium of Botanicals holds 47 constituent measurements and 3 adverse-effect records for Ammi majus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Ammi majus L.

47Constituent measurements

3Safety records

15Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Bergapten	Seed	Solvent extraction	≥ 0.217 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Bergapten	Seed	Solvent extraction	≤ 0.251 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Bergapten	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Coumarins	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Furanocoumarins	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Isopimpinellin	Seed	Solvent extraction	≥ 0.472 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Isopimpinellin	Seed	Solvent extraction	≤ 0.637 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Isopimpinellin	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Isopimpinellin	Fruit unspecified	Solvent extraction	—	HPLC-DAD	Resolve DOI
Methoxsalen	Fruit unspecified	Solvent extraction	—	HPLC-DAD	Resolve DOI
Methoxsalen	Seed	Solvent extraction	≥ 0.179 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Methoxsalen	Seed	Solvent extraction	≤ 0.366 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Methoxsalen	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Scopoletin	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Bergapten	Fruit unspecified	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Bergapten	Fruit unspecified	Solvent extraction	—	—	No resolvable identifier
Bergapten	Leaves	Solvent extraction	≤ 100 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Bergapten	Leaves	Solvent extraction	≤ 60 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Bergapten	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Bergapten	Seed	Solvent extraction	739.374 Milligram/100 gram	HPLC with standard detection methods	No resolvable identifier
Bergaptol	Fruit unspecified	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Furanocoumarins	Fruit unspecified	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Imperatorin	Fruit unspecified	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Imperatorin	Fruit unspecified	Solvent extraction	—	—	No resolvable identifier
Isoimperatorin	Fruit unspecified	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Isoimperatorin	Leaves	Solvent extraction	≤ 20 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Isopimpinellin	Leaves	Solvent extraction	≤ 10 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Isopimpinellin	Leaves	Solvent extraction	≤ 80 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Isopimpinellin	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Isopimpinellin	Fruit unspecified	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Isopimpinellin	Fruit unspecified	Solvent extraction	—	HPLC-DAD	No resolvable identifier
Isopimpinellin	Leaves	Solvent extraction	≥ 2 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
L-piperitone	Seed	Essential oil	10 Percent	Unspecified	No resolvable identifier
Marmesin	Leaves	Solvent extraction	≥ 2 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Marmesin	Leaves	Solvent extraction	≤ 40 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Marmesin	Roots and other underground parts	Solvent extraction	≥ 5 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Marmesin	Roots and other underground parts	Solvent extraction	≤ 30 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Marmesin	Fruit unspecified	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Methoxsalen	Leaves	Solvent extraction	≥ 10 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Methoxsalen	Leaves	Solvent extraction	≤ 80 Milligram/100 gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

40 of 47 records are shown, ordered so that records carrying a resolvable reference come first.

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	—	Unspecified	—	Bird (as animal)	Chronic/long term toxicity	Resolve DOI
Pulmonary and cardiac	Respiratory	—	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Other toxicities	—	—	—	Cattle (as animal)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Abu-Mustafa, Effat A., El-Bay, F. K. A., Fayez, M. B. E. Natural coumarins. XI. The distribution of coumarins in the Ammi majus plant and a possible pattern for their biogenetic evolution.. Planta medica, 1969, vol. 18, no. 1, p. 90-7.
Bartnik, Magdalena., Mazurek, Anna Katarzyna. Isolation of Methoxyfuranocoumarins From Ammi majus by Centrifugal Partition Chromatography . Journal of chromatographic science, 2016, vol. 54, no. 1, p. 10-16. DOI
Egyed, M N., Malkinson, M., Shlosberg, A. Observations on the experimental poisoning of young geese with Ammi majus. . Avian pathology : journal of the w.v.p.a, 1974, vol. 3, no. 2, p. 79-87. DOI
Shah, A.H., Qureshi, S., Tariq, M., Ageel, A.M. Toxicity studies on six plants used in the traditional Arab system of medicine. Phytotherapy research, 1989, vol. 3, no. 1, p. 25-29. DOI
Shlosberg, A., Egyed, M N. Examples of poisonous plants in Israel of importance to animals and man.. Archives of toxicology. supplement. = archiv fur toxikologie. supplement, 1983, vol. 6, p. 194-6.
Al-Qura'n, Saleh. Ethnobotanical survey of folk toxic plants in southern part of Jordan.. Toxicon, 2005, vol. 46, no. 2, p. 119-129.
Krivut, B.A., Perel'son, M.E. Spectrophotometric determination of furocoumarins in the seeds of Ammi majus L.. Pharmaceutical chemistry journal, 1967, vol. 1, no. 2, p. 100-102. DOI
Arab, S.T., Al-Nami, S.Y., Abu-Mustafa, E.A. Chemical composition of ammi majus l. and its inhibition activity against corrosion. Egyptian journal of chemistry, 2008, vol. 51, no. SPEC. ISS., p. 115-128.
KARAWYA, MS., KHAYYAL, SE., YOUSSEF, GF. ESTIMATION OF XANTHOTOXIN, IMPERATORIN AND BERGAPTEN IN AMMI-MAJUS FRUITS AND FORMULATIONS . Planta medica, 1970, vol. 18, no. 3, p. 195-&.
Krivut, B. A., Perel'son, M. E. Spectrophotometric determination of furocoumarins in the seeds of Ammi majus.. Khimiko-farmatsevticheskii zhurnal, 1967, vol. 1, no. 2, p. 46-8.
Pokrovskii, O. I., Markoliya, A. A., Lepeshkin, F. D., Kuvykin, I. V., Parenago, O. O., Gonchukov, S. A. Extraction of Linear Furocoumarins from Ammi Majus Seeds by Means of Supercritical Fluid Extraction and Supercritical Fluid Chromatography . Russian journal of physical chemistry b, 2009, vol. 3, no. 8, p. 1165-1171. DOI
Ashraf, Muhammad., Ahmad, Rafi., Bhatty, Muhammad Khurshid. Studies on the essential oils of the Pakistani species of the family Umbelliferae. Part XXX. Ammi majus seed oil.. Pakistan journal of scientific and industrial research, 1979, vol. 22, no. 5, p. 255-7.
Harsahay, M., Hemant Kr, P., Aarti, M., Mohd., N. Development of HPLC method for estimation of furonocumarins in Psoralea corylifolia and Ammi majus. International journal of pharmacognosy and phytochemical research, 2014, vol. 6, no. 2, p. 290-294.
ELGAMAL, MHA., SHALABY, NMM., DUDDECK, H., HIEGEMANN, M. COUMARINS AND COUMARIN GLUCOSIDES FROM THE FRUITS OF AMMI-MAJUS. Phytochemistry, 1993, vol. 34, no. 3, p. 819-823. DOI
Elgamal, M. H. A., Abu Mustafa, E. A., Sha laby, N. M. M. Isolation of komalin and isooxyimperatorin from the fruits of Ammi majus L.. Egyptian journal of pharmaceutical sciences, 1991, vol. 32, no. 1-2, p. 389-94.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature