Botanical species · safety record

Andrographis paniculata

The EFSA Compendium of Botanicals holds 11 constituent measurements and 5 adverse-effect records for Andrographis paniculata. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Andrographis paniculata (Burm.f.) Nees

11Constituent measurements

5Safety records

5Cited sources

269Licensed products (Canada)

Also recorded as

Justicia paniculata Burm. f.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 269 licensed products naming Andrographis paniculata as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
solid

Source material stated

Aerial parts
Aerial parts extract
Andrographis paniculata - Leaf
Dried aerial part(s)
Dried aerial parts (not less than 30% leaves)
Flower
Fresh above ground parts
Herb

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Andrographolide	Roots and other underground parts	Solvent extraction	26.53 Milligram/gram	HPLC-DAD	Resolve DOI
Andrographolide	Leaves	Solvent extraction	—	GC-MS (Q)	Resolve DOI
Andrographolide	Leaves	Solvent extraction	≥ 37.29 Milligram/gram	HPLC-DAD	Resolve DOI
Andrographolide	Leaves	Solvent extraction	≤ 38.83 Milligram/gram	HPLC-DAD	Resolve DOI
Andrographolide	Live plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Deoxyandrographolide	Leaves	Solvent extraction	≥ 26.49 Milligram/gram	HPLC-DAD	Resolve DOI
Deoxyandrographolide	Leaves	Solvent extraction	≤ 28.42 Milligram/gram	HPLC-DAD	Resolve DOI
Deoxyandrographolide	Roots and other underground parts	Solvent extraction	17.47 Milligram/gram	HPLC-DAD	Resolve DOI
Neoandrographolide	Roots and other underground parts	Solvent extraction	6.7 Milligram/gram	HPLC-DAD	Resolve DOI
Neoandrographolide	Leaves	Solvent extraction	≤ 11.45 Milligram/gram	HPLC-DAD	Resolve DOI
Neoandrographolide	Leaves	Solvent extraction	≥ 10.37 Milligram/gram	HPLC-DAD	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Reproductive	Testes	Leaves	—	Rat (as animal)	Reproduction toxicity	Resolve DOI
Digestive	Digestive	Leaves	Solvent extraction	—	In vitro	No resolvable identifier
Digestive	Digestive	Leaves	Solvent extraction	—	In vitro	No resolvable identifier
Digestive	Digestive	Leaves	Solvent extraction	—	In vitro	No resolvable identifier
Digestive	Digestive	Leaves	Solvent extraction	—	In vitro	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kurzawa, Marzanna., Filipiak-Szok, Anna., Klodzinska, Ewa., Szlyk, Edward. Determination of phytochemicals, antioxidant activity and total phenolic content in Andrographis paniculata using chromatographic methods . Journal of chromatography b-analytical technologies in the biomedical and life sciences, 2015, vol. 995, p. 101-106. DOI
Subramanian, Rammohan., Asmawi, M. Zaini., Sadikun, Amirin. In vitro alpha-glucosidase and alpha-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide . Acta biochimica polonica, 2008, vol. 55, no. 2, p. 391-398.
Edwin, Edward-Sam., Vasantha-Srinivasan, Prabhakaran., Senthil-Nathan, Sengottayan., Thanigaivel, Annamalai., Ponsankar, Athirstam., Pradeepa, Venkatraman., Selin-Rani, Selvaraj., Kalaivani, Kandaswamy., Hunter, Wayne B., Abdel-Megeed, Ahmed., Duraipandiyan, Veeramuthu., Al-Dhabi, Naif Abdullah. Anti-dengue efficacy of bioactive andrographolide from Andrographis paniculata (Lamiales: Acanthaceae) against the primary dengue vector Aedes aegypti (Diptera: Culicidae) . Acta tropica, 2016, vol. 163, p. 167-178. DOI
Akbarsha, MA., Murugaian, P. Aspects of the male reproductive toxicity/male antifertility property of andrographolide in albino rats: Effect on the testis and the cauda epididymidal spermatozoa . Phytotherapy research, 2000, vol. 14, no. 6, p. 432-435. DOI
Sheeja, K., Kuttan, G. Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide . Immunopharmacology and immunotoxicology, 2007, vol. 29, no. 1, p. 81-93. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature