Botanical species · safety record

Angelica dahurica

The EFSA Compendium of Botanicals holds 32 constituent measurements and 1 genotoxicity assay for Angelica dahurica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav.

32Constituent measurements

1Safety records

6Cited sources

638Licensed products (Canada)

Also recorded as

Angelica dahurica var. dahurica

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 638 licensed products naming Angelica dahurica as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Angelica dahurica, root
Dried root(s)
Leaf
New material
Radix
Rhizome
Root
Root and Rhizome

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Bergapten	Roots and other underground parts	Solvent extraction	—	LC-MS/MS	Resolve DOI
Bergapten	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Byakangelicol	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Falcarindiol	Roots and other underground parts	Solvent extraction	0.059 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Furanocoumarins	Roots and other underground parts	Solvent extraction	—	LC-MS/MS	Resolve DOI
Furanocoumarins	Roots and other underground parts	Super-critical gas extraction	≤ 1.59 Milligram/gram	GC-MS	Resolve DOI
Furanocoumarins	Roots and other underground parts	—	—	—	Resolve DOI
Furanocoumarins	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Furanocoumarins	Roots and other underground parts	Super-critical gas extraction	≥ 0.54 Milligram/gram	GC-MS	Resolve DOI
Furanocoumarins	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Imperatorin	Roots and other underground parts	Super-critical gas extraction	≥ 1.58 Milligram/gram	GC-MS	Resolve DOI
Imperatorin	Roots and other underground parts	Solvent extraction	—	LC-MS/MS	Resolve DOI
Imperatorin	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Imperatorin	Roots and other underground parts	Super-critical gas extraction	≤ 3.14 Milligram/gram	GC-MS	Resolve DOI
Imperatorin	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Imperatorin	Roots and other underground parts	Solvent extraction	0.025 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Isoimperatorin	Roots and other underground parts	Solvent extraction	—	LC-MS/MS	Resolve DOI
Isoimperatorin	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Isoimperatorin	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Isoimperatorin	Roots and other underground parts	Super-critical gas extraction	≥ 0.31 Milligram/gram	GC-MS	Resolve DOI
Isoimperatorin	Roots and other underground parts	Super-critical gas extraction	≤ 0.68 Milligram/gram	GC-MS	Resolve DOI
Isopimpinellin	Roots and other underground parts	Solvent extraction	—	LC-MS/MS	Resolve DOI
Nodakenin	Roots and other underground parts	Solvent extraction	0.002 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Oxypeucedanin	Roots and other underground parts	Solvent extraction	—	LC-MS/MS	Resolve DOI
Oxypeucedanin	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Oxypeucedanin	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Oxypeucedanin hydrate	Roots and other underground parts	Solvent extraction	0.06 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Phellopterin	Roots and other underground parts	Super-critical gas extraction	≥ 0.15 Milligram/gram	GC-MS	Resolve DOI
Phellopterin	Roots and other underground parts	Solvent extraction	0.018 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Phellopterin	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Phellopterin	Roots and other underground parts	Super-critical gas extraction	≤ 0.34 Milligram/gram	GC-MS	Resolve DOI
Psoralen	Roots and other underground parts	Solvent extraction	—	LC-MS/MS	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	—	other	Other	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kim, Young-Kyoon., Kim, Young Sup., Ryu, Shi Yong. Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines . Phytotherapy research, 2007, vol. 21, no. 3, p. 288-290. DOI
Choi, SY., Ahn, EM., Song, MC., Kim, DW., Kang, JH., Kwon, OS., Kang, TC., Baek, NI. In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica . Phytotherapy research, 2005, vol. 19, no. 10, p. 839-845. DOI
Zhou, J., Ouedraogo, M., Qu, F., Duez, P. Potential genotoxicity of traditional Chinese medicinal plants and phytochemicals: An overview. Phytotherapy Research, 2013, vol. 27, no. 12, p. 1745-1755. DOI
Chen, Qinhua., Li, Peng., He, Jing., Zhang, Zhuo., Liu, Jia. Supercritical fluid extraction for identification and determination of volatile metabolites from Angelica dahurica by GC-MS . Journal of separation science, 2008, vol. 31, no. 18, p. 3218-3224. DOI
Chen, Lin., Jian, Yang., Wei, Ning., Yuan, Mei., Zhuang, Xiaomei., Li, Hua. Separation and simultaneous quantification of nine furanocoumarins from Radix Angelicae dahuricae using liquid chromatography with tandem mass spectrometry for bioavailability determination in rats . Journal of separation science, 2015, vol. 38, no. 24, p. 4216-4224. DOI
Wu, Xiaoyi., Chao, Zhimao., Wang, Chun., Yu, Li. Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio. JOURNAL OF CHROMATOGRAPHY A, 2015, vol. 1384, p. 107-114. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature