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Botanical species · safety record

Angelica sinensis

The EFSA Compendium of Botanicals holds 7 constituent measurements and 1 adverse-effect record for Angelica sinensis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Angelica sinensis (Oliv.) Diels

7Constituent measurements
1Safety records
5Cited sources
2,912Licensed products (Canada)

Also recorded as

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 2,912 licensed products naming Angelica sinensis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

  • Dry
  • Extract Type TBA
  • Fresh
  • decoction
  • solid

Source material stated

  • Angelica sinensis - Root
  • Branches and roots
  • Dried root(s)
  • New material
  • Prepared root
  • Radix
  • Rhizome
  • Rhizome and root(s)

What the records describe

Constituents measured

  • Bergapten2
  • Ligustilide2
  • 3-butylidenephthalide1
  • Phenylpropanoids1
  • Z-ligustilide1

Plant parts

  • Roots and other underground parts4
  • Aerial part of plants3
  • Roots and other underground parts used as staple food1

Preparations

  • Solvent extraction6
  • Essential oil1

Effect types

  • Pulmonary and cardiac1

Target tissues

  • Cardiovascular1
  • haematological1

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
BergaptenAerial part of plantsSolvent extraction5.1 Microgram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
BergaptenAerial part of plantsSolvent extraction10.1 Microgram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
LigustilideRoots and other underground parts used as staple foodEssential oil—Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopyResolve DOI
LigustilideRoots and other underground partsSolvent extraction—UnspecifiedResolve DOI
3-butylidenephthalideRoots and other underground partsSolvent extraction—High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
PhenylpropanoidsRoots and other underground partsSolvent extraction—High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
Z-ligustilideRoots and other underground partsSolvent extraction—High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

EffectTarget tissuePlant partPreparationTest organismTest typeSource
Pulmonary and cardiacCardiovascular / haematologicalAerial part of plants—Human (as organism)Case reportResolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Zschocke, S., Liu, JH., Stuppner, H., Bauer, R. Comparative study of roots of Angelica sinensis and related umbelliferous drugs by thin layer chromatography, high-performance liquid chromatography, and liquid chromatography mass spectrometry. PHYTOCHEMICAL ANALYSIS, 1998, vol. 9, no. 6, p. 283-290.
  2. Brown, Amy C. Heart Toxicity Related to Herbs and Dietary Supplements: Online Table of Case Reports. Part 4 of 5. Journal of dietary supplements, 2018, vol. 15, no. 4, p. 516-555. DOI
  3. Lin, Y.-K., Sheu, M.-T., Huang, C.-H., Ho, H.-O. Development of a reversed-phase high-performance liquid Chromatographie method for analyzing furanoco�marin components in citrus fruit juices and Chinese herbal medicines. Journal of chromatographic science, 2009, vol. 47, no. 3, p. 211-215. DOI
  4. Long, Rui., Yang, Fang., Du, Jun-rong., Qian, Zhong-ming., Wang, Chen-yuan., Chen, Chu. Effects of Ligustilide on Tumor Growth and Immune Function in Institute of Cancer Research Mice. Tropical journal of pharmaceutical research, 2012, vol. 11, no. 3, p. 421-428. DOI
  5. Bunel, Valerian., Antoine, Marie-Helene., Nortier, Joelle., Duez, Pierre., Stevigny, Caroline. Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro. Toxicology in vitro, 2015, vol. 29, no. 3, p. 458-467. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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