Botanical species · safety record

Annona cherimola

The EFSA Compendium of Botanicals holds 51 constituent measurements and 1 genotoxicity assay for Annona cherimola. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Annona cherimola Mill.

51Constituent measurements
1Safety records
22Cited sources
0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

  • Acetogenins11
  • Alkaloids4
  • Liriodenine4
  • Annocherine a3
  • Annonacin3
  • Anolobine2
  • Anonaine2
  • Aporphine alkaloids2
  • Asimilobine2
  • Isoquinoline alkaloids2

Plant parts

  • Stem19
  • stalk19
  • Seed18
  • Leaves6
  • Aerial part of plants4
  • Roots and other underground parts3
  • Fruit unspecified1

Preparations

  • Solvent extraction50

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AlkaloidsRoots and other underground partsSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AlkaloidsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
Annocherine aSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
Annocherine aStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
Annocherine bStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AnnomontacinSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AnnonacinSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AnnonacinSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AnnonacinSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
CherianoineStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
IsoannonacinoneSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
Isoquinoline alkaloidsRoots and other underground partsSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
Kaurenoic acidsFruit unspecifiedSolvent extraction66 Milligram/pieceNuclear Magnetic Resonance (NMR)Resolve DOI
LiriodenineRoots and other underground partsSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
Romucosine hStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeed———No resolvable identifier
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopyNo resolvable identifier
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
AlkaloidsStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
AlkaloidsAerial part of plantsSolvent extraction—UnspecifiedNo resolvable identifier
Annocherine aStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
AnolobineLeavesSolvent extraction——No resolvable identifier
AnolobineStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
AnonaineStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
AnonaineAerial part of plantsSolvent extraction—UnspecifiedNo resolvable identifier
Aporphine alkaloidsLeavesSolvent extraction——No resolvable identifier
Aporphine alkaloidsStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
AsimilobineLeavesSolvent extraction——No resolvable identifier
AsimilobineStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
AtherospermidineStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
DiterpenesStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
IsocorydineStem / stalkSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier

40 of 51 records are shown, ordered so that records carrying a resolvable reference come first.

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

OutcomeEndpointTestTested organismMetabolic activationSource
Positive—in vitroOther—No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Alvarez Colom, Olga., Salvatore, Analia., Willink, Eduardo., Ordonez, Roxana., Isla, Maria I., Neske, Adriana., Bardon, Alicia. Insecticidal, Mutagenic and Genotoxic Evaluation of Annonaceous Acetogenins . Natural product communications, 2010, vol. 5, no. 3, p. 391-394.
  2. Chen, CY., Wu, YC. Annocherine C, a new C-alpha hydroxy benzylisoquinoline and other constituents from the leaves of Annona cherimola . Journal of the chinese chemical society, 2001, vol. 48, no. 6B, p. 1203-1206.
  3. Gonzalez-Coloma, A., Guadano, A., de Ines, C., Martinez-Diaz, R., Cortes, D. Selective action of acetogenin mitochondrial complex I inhibitors. Zeitschrift fur naturforschung c-a journal of biosciences, 2002, vol. 57, no. 11-12, p. 1028-1034.
  4. Chen, CY., Chang, FR., Teng, CM., Wu, YC. Cheritamine, a new N-fatty acyl tryptamine and other constituents from the stems of Annona cherimola . Journal of the chinese chemical society, 1999, vol. 46, no. 1, p. 77-86.
  5. Martinez-Vazquez, M., Lozano, DGDC., Estrada-Reyes, R., Gonzalez-Lugo, NM., Apan, TR., Heinze, G. Bio-guided isolation of the cytotoxic corytenchine and isocoreximine from roots of Annona cherimolia . Fitoterapia, 2005, vol. 76, no. 7-8, p. 733-736. DOI
  6. CHULIA, S., NOGUERA, MA., IVORRA, MD., CORTES, D., DOCON, MP. VASODILATOR EFFECTS OF LIRIODENINE AND NORUSHINSUNINE, 2 APORPHINE ALKALOIDS ISOLATED FROM ANNONA-CHERIMOLIA, IN RAT AORTA . Pharmacology, 1995, vol. 50, no. 6, p. 380-387. DOI
  7. Kim, DH., Ma, FS., Suk, KD., Son, JK., Lee, JS., Woo, MH. Annomolin and annocherimolin, new cytotoxic annonaceous acetogenins from Annona cherimolia seeds . Journal of natural products, 2001, vol. 64, no. 4, p. 502-506. DOI
  8. Son, JK., Kim, DH., Woo, MH. Two new epimeric pairs of acetogenins bearing a carbonyl group from Annona cherimolia seeds . Journal of natural products, 2003, vol. 66, no. 10, p. 1369-1372. DOI
  9. Garcia-Aguirre, Karol Karla., Zepeda-Vallejo, Luis Gerardo., Ramon-Gallegos, Eva., Alvarez-Gonzalez, Isela., Madrigal-Bujaidar, Eduardo. Genotoxic and Cytotoxic Effects Produced by Acetogenins Obtained from Annona cherimolia MILL. . Biological & pharmaceutical bulletin, 2008, vol. 31, no. 12, p. 2346-2349. DOI
  10. Kim, DH., Son, JK., Woo, MH. Annomocherin, annonacin and annomontacin: A novel and two known bioactive mono-tetrahydrofuran annonaceous acetogenins from Annona cherimolia seeds . Archives of pharmacal research, 2001, vol. 24, no. 4, p. 300-306. DOI
  11. Kim, Dal Hwan., Fang, Zhe., Lee, Young Eun., Woo, Mi Hee. Xylomaticin and gonionenin, cytotoxic annonaceous acetogenins from the seeds of Annona cherimolia. Natural product sciences, 2007, vol. 13, no. 4, p. 355-358.
  12. Woo, MH., Chung, SO., Kim, DH. cis-Annonacin and (2,4)-cis-and trans-isoannonacins: Cytotoxic monotetrahydrofuran annonaceous acetogenins from the seeds of Annona cherimolia . Archives of pharmacal research, 1999, vol. 22, no. 5, p. 524-528. DOI
  13. Woo, MH., Kim, DH., Fotopoulos, SS., McLaughlin, JL. Annocherin and (2,4)-cis- and trans-annocherinones, monotetrahydrofuran annonaceous acetogenins with a C-7 carbonyl group from Annona cherimolia seeds . Journal of natural products, 1999, vol. 62, no. 9, p. 1250-1255. DOI
  14. Alvarez Colom, O., Neske, A., Popich, S., Bard�n, A. Toxic effects of annonaceous acetogenins from Annona cherimolia (Magnoliales: Annonaceae) on Spodoptera frugiperda (Lepidoptera: Noctuidae). Journal of pest science, 2007, vol. 80, no. 1, p. 63-67. DOI
  15. CORTES, D., MYINT, SH., HOCQUEMILLER, R. ACETOGENINS OF ANNONACEAE .12. MOLVIZARIN AND MOTRILIN - 2 NOVEL CYTOTOXIC BIS-TETRAHYDROFURANIC GAMMA-LACTONE ACETOGENINS FROM ANNONA-CHERIMOLIA . Tetrahedron, 1991, vol. 47, no. 38, p. 8195-8202. DOI
  16. CORTES, D., MYINT, SH., LEBOEUF, M., CAVE, A. ACETOGENINS OF ANNONACEAE .13. A NEW TYPE OF CYTOTOXIC ACETOGENINS - THE TETRAHYDROFURANIC BETA-HYDROXY METHYL GAMMA-LACTONES . Tetrahedron letters, 1991, vol. 32, no. 43, p. 6133-6134. DOI
  17. Sahpaz, S., Gonzalez, MC., Hocquemiller, R., ZafraPolo, MC., Cortes, D. Annosenegalin and annogalene: Two cytotoxic mono-tetrahydrofuran acetogenins from Annona senegalensis and Annona cherimolia . Phytochemistry, 1996, vol. 42, no. 1, p. 103-107. DOI
  18. Chen, CY., Chang, FR., Pan, WB., Wu, YC. Four alkaloids from Annona cherimola. Phytochemistry, 2001, vol. 56, no. 7, p. 753-757. DOI
  19. Chen, CY., Chang, FR., Wu, YC. The constituents from the stems of Annona cherimola. Journal of the chinese chemical society, 1997, vol. 44, no. 3, p. 313-319.
  20. Chen, CY., Wu, TY., Chang, FR., Wu, YC. Lignans and kauranes from the stems of Annona cherimola. Journal of the chinese chemical society, 1998, vol. 45, no. 5, p. 629-634.
  21. Guillope, R., Escobar-Khondiker, M., Guerineau, V., Laprevote, O., Hoeglinger, G. U., Champy, P. Kaurenoic Acid from Pulp of Annona cherimolia in regard to Annonaceae-induced Parkinsonism . Phytotherapy research, 2011, vol. 25, no. 12, p. 1861-1864. DOI
  22. Martinez-Vazquez, Mariano., Estrada-Reyes, Rosa. SECONDARY METABOLISMIN IN ANNONACEAE: POTENCIAL SOURCE OF DRUGS. Revista brasileira de fruticultura, 2014, vol. 36, no. 1, p. 141-146.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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