Botanical species · safety record
Annona cherimola
The EFSA Compendium of Botanicals holds 51 constituent measurements and 1 genotoxicity assay for Annona cherimola. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Annona cherimola Mill.
Regulatory presence
No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.
What the records describe
Constituents measured
- Acetogenins11
- Alkaloids4
- Liriodenine4
- Annocherine a3
- Annonacin3
- Anolobine2
- Anonaine2
- Aporphine alkaloids2
- Asimilobine2
- Isoquinoline alkaloids2
Plant parts
- Stem19
- stalk19
- Seed18
- Leaves6
- Aerial part of plants4
- Roots and other underground parts3
- Fruit unspecified1
Preparations
- Solvent extraction50
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Acetogenins | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Acetogenins | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Acetogenins | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Acetogenins | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Acetogenins | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Acetogenins | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Acetogenins | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Acetogenins | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Alkaloids | Roots and other underground parts | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Alkaloids | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Annocherine a | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Annocherine a | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Annocherine b | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Annomontacin | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Annonacin | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Annonacin | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Annonacin | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Cherianoine | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Isoannonacinone | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Isoquinoline alkaloids | Roots and other underground parts | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Kaurenoic acids | Fruit unspecified | Solvent extraction | 66 Milligram/piece | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Liriodenine | Roots and other underground parts | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Romucosine h | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Acetogenins | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Acetogenins | Seed | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy | No resolvable identifier |
| Acetogenins | Seed | — | — | — | No resolvable identifier |
| Alkaloids | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Alkaloids | Aerial part of plants | Solvent extraction | — | Unspecified | No resolvable identifier |
| Annocherine a | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Anolobine | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Anolobine | Leaves | Solvent extraction | — | — | No resolvable identifier |
| Anonaine | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Anonaine | Aerial part of plants | Solvent extraction | — | Unspecified | No resolvable identifier |
| Aporphine alkaloids | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Aporphine alkaloids | Leaves | Solvent extraction | — | — | No resolvable identifier |
| Asimilobine | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Asimilobine | Leaves | Solvent extraction | — | — | No resolvable identifier |
| Atherospermidine | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Diterpenes | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Isocorydine | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
40 of 51 records are shown, ordered so that records carrying a resolvable reference come first.
Genotoxicity testing
Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.
| Outcome | Endpoint | Test | Tested organism | Metabolic activation | Source |
|---|---|---|---|---|---|
| Positive | — | in vitro | Other | — | No resolvable identifier |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Chen, CY., Chang, FR., Wu, YC. The constituents from the stems of Annona cherimola. Journal of the chinese chemical society, 1997, vol. 44, no. 3, p. 313-319.
- Woo, MH., Chung, SO., Kim, DH. cis-Annonacin and (2,4)-cis-and trans-isoannonacins: Cytotoxic monotetrahydrofuran annonaceous acetogenins from the seeds of Annona cherimolia . Archives of pharmacal research, 1999, vol. 22, no. 5, p. 524-528. DOI
- Chen, CY., Wu, YC. Annocherine C, a new C-alpha hydroxy benzylisoquinoline and other constituents from the leaves of Annona cherimola . Journal of the chinese chemical society, 2001, vol. 48, no. 6B, p. 1203-1206.
- Martinez-Vazquez, Mariano., Estrada-Reyes, Rosa. SECONDARY METABOLISMIN IN ANNONACEAE: POTENCIAL SOURCE OF DRUGS. Revista brasileira de fruticultura, 2014, vol. 36, no. 1, p. 141-146.
- Sahpaz, S., Gonzalez, MC., Hocquemiller, R., ZafraPolo, MC., Cortes, D. Annosenegalin and annogalene: Two cytotoxic mono-tetrahydrofuran acetogenins from Annona senegalensis and Annona cherimolia . Phytochemistry, 1996, vol. 42, no. 1, p. 103-107. DOI
- Kim, DH., Son, JK., Woo, MH. Annomocherin, annonacin and annomontacin: A novel and two known bioactive mono-tetrahydrofuran annonaceous acetogenins from Annona cherimolia seeds . Archives of pharmacal research, 2001, vol. 24, no. 4, p. 300-306. DOI
- Chen, CY., Chang, FR., Pan, WB., Wu, YC. Four alkaloids from Annona cherimola. Phytochemistry, 2001, vol. 56, no. 7, p. 753-757. DOI
- Garcia-Aguirre, Karol Karla., Zepeda-Vallejo, Luis Gerardo., Ramon-Gallegos, Eva., Alvarez-Gonzalez, Isela., Madrigal-Bujaidar, Eduardo. Genotoxic and Cytotoxic Effects Produced by Acetogenins Obtained from Annona cherimolia MILL. . Biological & pharmaceutical bulletin, 2008, vol. 31, no. 12, p. 2346-2349. DOI
- Alvarez Colom, Olga., Salvatore, Analia., Willink, Eduardo., Ordonez, Roxana., Isla, Maria I., Neske, Adriana., Bardon, Alicia. Insecticidal, Mutagenic and Genotoxic Evaluation of Annonaceous Acetogenins . Natural product communications, 2010, vol. 5, no. 3, p. 391-394.
- Son, JK., Kim, DH., Woo, MH. Two new epimeric pairs of acetogenins bearing a carbonyl group from Annona cherimolia seeds . Journal of natural products, 2003, vol. 66, no. 10, p. 1369-1372. DOI
- Chen, CY., Chang, FR., Teng, CM., Wu, YC. Cheritamine, a new N-fatty acyl tryptamine and other constituents from the stems of Annona cherimola . Journal of the chinese chemical society, 1999, vol. 46, no. 1, p. 77-86.
- CHULIA, S., NOGUERA, MA., IVORRA, MD., CORTES, D., DOCON, MP. VASODILATOR EFFECTS OF LIRIODENINE AND NORUSHINSUNINE, 2 APORPHINE ALKALOIDS ISOLATED FROM ANNONA-CHERIMOLIA, IN RAT AORTA . Pharmacology, 1995, vol. 50, no. 6, p. 380-387. DOI
- Chen, CY., Wu, TY., Chang, FR., Wu, YC. Lignans and kauranes from the stems of Annona cherimola. Journal of the chinese chemical society, 1998, vol. 45, no. 5, p. 629-634.
- Guillope, R., Escobar-Khondiker, M., Guerineau, V., Laprevote, O., Hoeglinger, G. U., Champy, P. Kaurenoic Acid from Pulp of Annona cherimolia in regard to Annonaceae-induced Parkinsonism . Phytotherapy research, 2011, vol. 25, no. 12, p. 1861-1864. DOI
- Martinez-Vazquez, M., Lozano, DGDC., Estrada-Reyes, R., Gonzalez-Lugo, NM., Apan, TR., Heinze, G. Bio-guided isolation of the cytotoxic corytenchine and isocoreximine from roots of Annona cherimolia . Fitoterapia, 2005, vol. 76, no. 7-8, p. 733-736. DOI
- Woo, MH., Kim, DH., Fotopoulos, SS., McLaughlin, JL. Annocherin and (2,4)-cis- and trans-annocherinones, monotetrahydrofuran annonaceous acetogenins with a C-7 carbonyl group from Annona cherimolia seeds . Journal of natural products, 1999, vol. 62, no. 9, p. 1250-1255. DOI
- Kim, Dal Hwan., Fang, Zhe., Lee, Young Eun., Woo, Mi Hee. Xylomaticin and gonionenin, cytotoxic annonaceous acetogenins from the seeds of Annona cherimolia. Natural product sciences, 2007, vol. 13, no. 4, p. 355-358.
- Gonzalez-Coloma, A., Guadano, A., de Ines, C., Martinez-Diaz, R., Cortes, D. Selective action of acetogenin mitochondrial complex I inhibitors. Zeitschrift fur naturforschung c-a journal of biosciences, 2002, vol. 57, no. 11-12, p. 1028-1034.
- Alvarez Colom, O., Neske, A., Popich, S., Bard�n, A. Toxic effects of annonaceous acetogenins from Annona cherimolia (Magnoliales: Annonaceae) on Spodoptera frugiperda (Lepidoptera: Noctuidae). Journal of pest science, 2007, vol. 80, no. 1, p. 63-67. DOI
- CORTES, D., MYINT, SH., HOCQUEMILLER, R. ACETOGENINS OF ANNONACEAE .12. MOLVIZARIN AND MOTRILIN - 2 NOVEL CYTOTOXIC BIS-TETRAHYDROFURANIC GAMMA-LACTONE ACETOGENINS FROM ANNONA-CHERIMOLIA . Tetrahedron, 1991, vol. 47, no. 38, p. 8195-8202. DOI
- CORTES, D., MYINT, SH., LEBOEUF, M., CAVE, A. ACETOGENINS OF ANNONACEAE .13. A NEW TYPE OF CYTOTOXIC ACETOGENINS - THE TETRAHYDROFURANIC BETA-HYDROXY METHYL GAMMA-LACTONES . Tetrahedron letters, 1991, vol. 32, no. 43, p. 6133-6134. DOI
- Kim, DH., Ma, FS., Suk, KD., Son, JK., Lee, JS., Woo, MH. Annomolin and annocherimolin, new cytotoxic annonaceous acetogenins from Annona cherimolia seeds . Journal of natural products, 2001, vol. 64, no. 4, p. 502-506. DOI
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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