Botanical species · safety record

Annona cherimola

The EFSA Compendium of Botanicals holds 51 constituent measurements and 1 genotoxicity assay for Annona cherimola. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Annona cherimola Mill.

51Constituent measurements
1Safety records
22Cited sources
0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

  • Acetogenins11
  • Alkaloids4
  • Liriodenine4
  • Annocherine a3
  • Annonacin3
  • Anolobine2
  • Anonaine2
  • Aporphine alkaloids2
  • Asimilobine2
  • Isoquinoline alkaloids2

Plant parts

  • Stem19
  • stalk19
  • Seed18
  • Leaves6
  • Aerial part of plants4
  • Roots and other underground parts3
  • Fruit unspecified1

Preparations

  • Solvent extraction50

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
AcetogeninsSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AlkaloidsRoots and other underground partsSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AlkaloidsSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
Annocherine aSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
Annocherine aStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
Annocherine bStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AnnomontacinSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AnnonacinSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AnnonacinSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AnnonacinSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
CherianoineStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
IsoannonacinoneSeedSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
Isoquinoline alkaloidsRoots and other underground partsSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
Kaurenoic acidsFruit unspecifiedSolvent extraction66 Milligram/pieceNuclear Magnetic Resonance (NMR)Resolve DOI
LiriodenineRoots and other underground partsSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
Romucosine hStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
AcetogeninsSeedSolvent extractionNuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopyNo resolvable identifier
AcetogeninsSeedNo resolvable identifier
AlkaloidsStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
AlkaloidsAerial part of plantsSolvent extractionUnspecifiedNo resolvable identifier
Annocherine aStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
AnolobineStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
AnolobineLeavesSolvent extractionNo resolvable identifier
AnonaineStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
AnonaineAerial part of plantsSolvent extractionUnspecifiedNo resolvable identifier
Aporphine alkaloidsStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
Aporphine alkaloidsLeavesSolvent extractionNo resolvable identifier
AsimilobineStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
AsimilobineLeavesSolvent extractionNo resolvable identifier
AtherospermidineStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
DiterpenesStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
IsocorydineStem / stalkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier

40 of 51 records are shown, ordered so that records carrying a resolvable reference come first.

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

OutcomeEndpointTestTested organismMetabolic activationSource
Positivein vitroOtherNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Chen, CY., Chang, FR., Wu, YC. The constituents from the stems of Annona cherimola. Journal of the chinese chemical society, 1997, vol. 44, no. 3, p. 313-319.
  2. Woo, MH., Chung, SO., Kim, DH. cis-Annonacin and (2,4)-cis-and trans-isoannonacins: Cytotoxic monotetrahydrofuran annonaceous acetogenins from the seeds of Annona cherimolia . Archives of pharmacal research, 1999, vol. 22, no. 5, p. 524-528. DOI
  3. Chen, CY., Wu, YC. Annocherine C, a new C-alpha hydroxy benzylisoquinoline and other constituents from the leaves of Annona cherimola . Journal of the chinese chemical society, 2001, vol. 48, no. 6B, p. 1203-1206.
  4. Martinez-Vazquez, Mariano., Estrada-Reyes, Rosa. SECONDARY METABOLISMIN IN ANNONACEAE: POTENCIAL SOURCE OF DRUGS. Revista brasileira de fruticultura, 2014, vol. 36, no. 1, p. 141-146.
  5. Sahpaz, S., Gonzalez, MC., Hocquemiller, R., ZafraPolo, MC., Cortes, D. Annosenegalin and annogalene: Two cytotoxic mono-tetrahydrofuran acetogenins from Annona senegalensis and Annona cherimolia . Phytochemistry, 1996, vol. 42, no. 1, p. 103-107. DOI
  6. Kim, DH., Son, JK., Woo, MH. Annomocherin, annonacin and annomontacin: A novel and two known bioactive mono-tetrahydrofuran annonaceous acetogenins from Annona cherimolia seeds . Archives of pharmacal research, 2001, vol. 24, no. 4, p. 300-306. DOI
  7. Chen, CY., Chang, FR., Pan, WB., Wu, YC. Four alkaloids from Annona cherimola. Phytochemistry, 2001, vol. 56, no. 7, p. 753-757. DOI
  8. Garcia-Aguirre, Karol Karla., Zepeda-Vallejo, Luis Gerardo., Ramon-Gallegos, Eva., Alvarez-Gonzalez, Isela., Madrigal-Bujaidar, Eduardo. Genotoxic and Cytotoxic Effects Produced by Acetogenins Obtained from Annona cherimolia MILL. . Biological & pharmaceutical bulletin, 2008, vol. 31, no. 12, p. 2346-2349. DOI
  9. Alvarez Colom, Olga., Salvatore, Analia., Willink, Eduardo., Ordonez, Roxana., Isla, Maria I., Neske, Adriana., Bardon, Alicia. Insecticidal, Mutagenic and Genotoxic Evaluation of Annonaceous Acetogenins . Natural product communications, 2010, vol. 5, no. 3, p. 391-394.
  10. Son, JK., Kim, DH., Woo, MH. Two new epimeric pairs of acetogenins bearing a carbonyl group from Annona cherimolia seeds . Journal of natural products, 2003, vol. 66, no. 10, p. 1369-1372. DOI
  11. Chen, CY., Chang, FR., Teng, CM., Wu, YC. Cheritamine, a new N-fatty acyl tryptamine and other constituents from the stems of Annona cherimola . Journal of the chinese chemical society, 1999, vol. 46, no. 1, p. 77-86.
  12. CHULIA, S., NOGUERA, MA., IVORRA, MD., CORTES, D., DOCON, MP. VASODILATOR EFFECTS OF LIRIODENINE AND NORUSHINSUNINE, 2 APORPHINE ALKALOIDS ISOLATED FROM ANNONA-CHERIMOLIA, IN RAT AORTA . Pharmacology, 1995, vol. 50, no. 6, p. 380-387. DOI
  13. Chen, CY., Wu, TY., Chang, FR., Wu, YC. Lignans and kauranes from the stems of Annona cherimola. Journal of the chinese chemical society, 1998, vol. 45, no. 5, p. 629-634.
  14. Guillope, R., Escobar-Khondiker, M., Guerineau, V., Laprevote, O., Hoeglinger, G. U., Champy, P. Kaurenoic Acid from Pulp of Annona cherimolia in regard to Annonaceae-induced Parkinsonism . Phytotherapy research, 2011, vol. 25, no. 12, p. 1861-1864. DOI
  15. Martinez-Vazquez, M., Lozano, DGDC., Estrada-Reyes, R., Gonzalez-Lugo, NM., Apan, TR., Heinze, G. Bio-guided isolation of the cytotoxic corytenchine and isocoreximine from roots of Annona cherimolia . Fitoterapia, 2005, vol. 76, no. 7-8, p. 733-736. DOI
  16. Woo, MH., Kim, DH., Fotopoulos, SS., McLaughlin, JL. Annocherin and (2,4)-cis- and trans-annocherinones, monotetrahydrofuran annonaceous acetogenins with a C-7 carbonyl group from Annona cherimolia seeds . Journal of natural products, 1999, vol. 62, no. 9, p. 1250-1255. DOI
  17. Kim, Dal Hwan., Fang, Zhe., Lee, Young Eun., Woo, Mi Hee. Xylomaticin and gonionenin, cytotoxic annonaceous acetogenins from the seeds of Annona cherimolia. Natural product sciences, 2007, vol. 13, no. 4, p. 355-358.
  18. Gonzalez-Coloma, A., Guadano, A., de Ines, C., Martinez-Diaz, R., Cortes, D. Selective action of acetogenin mitochondrial complex I inhibitors. Zeitschrift fur naturforschung c-a journal of biosciences, 2002, vol. 57, no. 11-12, p. 1028-1034.
  19. Alvarez Colom, O., Neske, A., Popich, S., Bard�n, A. Toxic effects of annonaceous acetogenins from Annona cherimolia (Magnoliales: Annonaceae) on Spodoptera frugiperda (Lepidoptera: Noctuidae). Journal of pest science, 2007, vol. 80, no. 1, p. 63-67. DOI
  20. CORTES, D., MYINT, SH., HOCQUEMILLER, R. ACETOGENINS OF ANNONACEAE .12. MOLVIZARIN AND MOTRILIN - 2 NOVEL CYTOTOXIC BIS-TETRAHYDROFURANIC GAMMA-LACTONE ACETOGENINS FROM ANNONA-CHERIMOLIA . Tetrahedron, 1991, vol. 47, no. 38, p. 8195-8202. DOI
  21. CORTES, D., MYINT, SH., LEBOEUF, M., CAVE, A. ACETOGENINS OF ANNONACEAE .13. A NEW TYPE OF CYTOTOXIC ACETOGENINS - THE TETRAHYDROFURANIC BETA-HYDROXY METHYL GAMMA-LACTONES . Tetrahedron letters, 1991, vol. 32, no. 43, p. 6133-6134. DOI
  22. Kim, DH., Ma, FS., Suk, KD., Son, JK., Lee, JS., Woo, MH. Annomolin and annocherimolin, new cytotoxic annonaceous acetogenins from Annona cherimolia seeds . Journal of natural products, 2001, vol. 64, no. 4, p. 502-506. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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