Botanical species · safety record

Annona muricata

The EFSA Compendium of Botanicals holds 26 constituent measurements for Annona muricata. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Annona muricata L.

26Constituent measurements

0Safety records

12Cited sources

31Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 31 licensed products naming Annona muricata as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Fruit
Fruit flesh
Fruit pulp
Herb
Leaf
Leaves
Root

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Acetogenins	Leaves	Solvent extraction	17.4 Microgram/gram	LC-MS	Resolve DOI
Acetogenins	Leaves	—	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Acetogenins	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Acetogenins	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Acetogenins	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Acetogenins	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Acetogenins	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Annonacin	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Annonacin	Leaves	Solvent extraction	305.6 Microgram/gram	LC-MS	Resolve DOI
Coreximine	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy	Resolve DOI
N-methylcoclaurine	Leaves	Solvent extraction	—	LC-MS-MS (QqQ)	Resolve DOI
N-methylcoclaurine	Fruit unspecified	Solvent extraction	—	LC-MS-MS (QqQ)	Resolve DOI
Reticuline	Fruit unspecified	Solvent extraction	—	LC-MS-MS (QqQ)	Resolve DOI
Reticuline	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy	Resolve DOI
Alkaloids	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Annonacin	Roots and other underground parts	Solvent extraction	—	Chromatographic tests	No resolvable identifier
Asimilobine	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Cardiac glycosides	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Coreximine	Roots and other underground parts	Solvent extraction	—	Chromatographic tests	No resolvable identifier
Coumarins	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Isoquinoline alkaloids	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Nornuciferine	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Quinones	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Reticuline	Roots and other underground parts	Solvent extraction	—	Chromatographic tests	No resolvable identifier
Saponins	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannins	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Lannuzel, A., Michel, PP., Caparros-Lefebvre, D., Abaul, J., Hocquemiller, R., Ruberg, M. Toxicity of Annonaceae for dopaminergic neurons: Potential role in atypical parkinsonism in Guadeloupe . Movement disorders, 2002, vol. 17, no. 1, p. 84-90. DOI
Vijayalingam, T. A., Rajesh, N. V., Devi, R. Kalpana. Antipediculicidal activity of seed extracts of Annona muricata Linn.. Annals of phytomedicine-an international journal, 2016, vol. 5, no. 1, p. 122-126.
Hasrat, JA., Pieters, L., DeBacker, JP., Vauquelin, G., Vlietinck, AJ. Medicinal plants from Suriname - Screening of medicinal plants from Suriname for 5-HT1A ligands: Bioactive isoquinoline alkaloids from the fruit of Annona muricata . Phytomedicine, 1997, vol. 4, no. 2, p. 133-140.
Rieser, MJ., Gu, ZM., Fang, XP., Zeng, L., Wood, KV., McLaughlin, JL. Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata . Journal of natural products, 1996, vol. 59, no. 2, p. 100-108. DOI
Lannuzel, A., Hoglinger, G. U., Champy, P., Michel, P. P., Hirsch, E. C., Ruberg, M. Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae? . Journal of neural transmission-supplement, 2006, no. 70, p. 153-157.
Machado de Moraes, Ingrid Vieira., Vasconcelos Ribeiro, Paulo Riceli., Schmidt, Flavio Luis., Canuto, Kirley Marques., Zocolo, Guilherme Juliao., de Brito, Edy Sousa., Luo, Rensheng., Richards, Kristy M., Tran, Kevin., Smith, Robert E. UPLC-QTOF-MS and NMR analyses of graviola (Annona muricata) leaves. Revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2016, vol. 26, no. 2, p. 174-179. DOI
ZENG, L., WU, FE., GU, ZM., MCLAUGHLIN, JL. MURIHEXOCIN-A AND MURIHEXOCIN-B, 2 NOVEL MONO-THF ACETOGENINS WITH 6 HYDROXYLS, FROM ANNONA-MURICATA (ANNONACEAE) . Tetrahedron letters, 1995, vol. 36, no. 30, p. 5291-5294. DOI
Kim, GS., Zeng, L., Alali, F., Rogers, LL., Wu, FE., Sastrodihardjo, S., McLaughlin, JL. Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata . Phytochemistry, 1998, vol. 49, no. 2, p. 565-571. DOI
Vila-Nova, Nadja Soares., de Morais, Selene Maia., Cajazeiras Falcao, Maria Jose., Negreiros Alcantara, Terezinha Thaize., Travassos Ferreira, Pablito Augusto., Barreira Cavalcanti, Eveline Solon., Pinto Vieira, Icaro Gusmao., Campello, Claudio Cabral., Wilson, Mary. Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone . Experimental parasitology, 2013, vol. 133, no. 3, p. 334-338. DOI
WU, FE., ZHAO, GX., ZENG, L., ZHANG, Y., SCHWEDLER, JT., MCLAUGHLIN, JL., SASTRODIHARDJO, S. ADDITIONAL BIOACTIVE ACETOGENINS, ANNOMUTACIN AND (2,4-TRANS)-10R-ANNONACIN-A-ONES AND (2,4-CIS)-10R-ANNONACIN-A-ONES, FROM THE LEAVES OF ANNONA-MURICATA . Journal of natural products-lloydia, 1995, vol. 58, no. 9, p. 1430-1437. DOI
Kim, G., Zeng, L., Alali, F., Rogers, LL., Wu, FE., McLaughlin, JL., Sastrodihardjo, S. Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of Annona muricata . Journal of natural products, 1998, vol. 61, no. 4, p. 432-436. DOI
Kotake, Y., Okuda, K., Kamizono, M., Matsumoto, N., Tanahashi, T., Hara, H., Caparros-Lefebvre, D., Ohta, S. Detection and determination of reticuline and N-methylcoculaurine in the Annonaceae family using liquid chromatography-tandem mass spectrometry . Journal of chromatography b-analytical technologies in the biomedical and life sciences, 2004, vol. 806, no. 1, p. 75-78. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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