Botanical species · safety record

Annona squamosa

The EFSA Compendium of Botanicals holds 25 constituent measurements, 3 adverse-effect records and 3 genotoxicity assays for Annona squamosa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Annona squamosa L.

25Constituent measurements

6Safety records

12Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-cineole	Fruit unspecified	Solvent extraction	1.4 Percent	GC-MS	Resolve DOI
Acetogenins	Leaves	Solvent extraction	—	IR and Raman Spectroscopy	Resolve DOI
Acetogenins	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Acetogenins	Fruit unspecified	Solvent extraction	—	HPLC-UV	Resolve DOI
Acetogenins	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Acetogenins	Fruit unspecified	Solvent extraction	≥ 180 Milligram/kilogram	HPLC-UV	Resolve DOI
Acetogenins	Fruit unspecified	Solvent extraction	≤ 260 Milligram/kilogram	HPLC-UV	Resolve DOI
Acetogenins	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Acetogenins	Seed	Solvent extraction	—	HPLC-UV	Resolve DOI
Alkaloids	Leaves	Solvent extraction	—	IR and Raman Spectroscopy	Resolve DOI
Annonacin	Fruit unspecified	Solvent extraction	—	HPLC-UV	Resolve DOI
(-)-camphor	Roots and other underground parts	Solvent extraction	—	—	No resolvable identifier
Acetogenins	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Alkaloids	Fruit unspecified	Solvent extraction	—	—	No resolvable identifier
Anonaine	Fruit unspecified	Solvent extraction	—	—	No resolvable identifier
Anonaine	Roots and other underground parts	Solvent extraction	—	—	No resolvable identifier
Asimilobine	Fruit unspecified	Solvent extraction	—	—	No resolvable identifier
Coclaurine	Fruit unspecified	Solvent extraction	—	—	No resolvable identifier
Corydine	Roots and other underground parts	Solvent extraction	—	—	No resolvable identifier
Glaucine	Roots and other underground parts	Solvent extraction	—	—	No resolvable identifier
Isocorydine	Roots and other underground parts	Solvent extraction	—	—	No resolvable identifier
Liriodenine	Fruit unspecified	Solvent extraction	—	—	No resolvable identifier
N-methylcoclaurine	Fruit unspecified	Solvent extraction	—	—	No resolvable identifier
Nornuciferine	Fruit unspecified	Solvent extraction	—	—	No resolvable identifier
Reticuline	Fruit unspecified	Solvent extraction	—	—	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Liver	Seed	—	Rat (as animal)	Short-term toxicity	Resolve DOI
Digestive	Liver	Seed	—	Rat (as animal)	Short-term toxicity	Resolve DOI
Not reported	Digestive	Seed	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	micronucleus assay	Rat (as animal)	Not applicable	Resolve DOI
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Rat (as animal)	Not applicable	Resolve DOI
Positive	chromosome aberration	chromosome aberration assay	Rat (as animal)	Not applicable	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Wu, Yang-Chang., Chang, Fang-Rong., Chen, Keh-Shaw., Ko, Feng-Nien., Teng, Che-Ming. Bioactive alkaloids from Annona squamosa. Chinese pharmaceutical journal, 1994, vol. 46, no. 5, p. 438-446.
Wang Yu., Chen Yong., Qiu Hai-long., Miao Jun-jie., Chen Jian-wei., Li Xiang. Toxicity and mechanism of total annonaceous acetogenins on heart, liver and kidney of rats . Zhongguo yaolixue yu dulixue zazhi, 2013, vol. 27, no. 3, p. 434-439. DOI
Rao, R. V. Krishna., Murty, Narasimha., Rao, J. V. L. N. Seshagiri. Occurrence of borneol and camphor and a new terpene in Annona squamosa. Indian journal of pharmaceutical sciences, 1978, vol. 40, no. 5, p. 170-1.
Grover, Paramjit., Singh, S. P., Prabhakar, P. V., Reddy, Utkarsh A., Balasubramanyam, A., Mahboob, M., Rahman, M. F., Misra, Sunil. In vivo assessment of genotoxic effects of Annona squamosa seed extract in rats . Food and chemical toxicology, 2009, vol. 47, no. 8, p. 1964-1971. DOI
Shashirekha, Mysore N., Baskaran, Revathy., Rao, Lingamallu Jaganmohan., Vijayalakshmi, Munusamy R., Rajarathnam, Somasundaram. Influence of processing conditions on flavour compounds of custard apple (Annona squamosa L.) . Lwt-food science and technology, 2008, vol. 41, no. 2, p. 236-243. DOI
Vila-Nova, Nadja Soares., de Morais, Selen Maia., Cajazeiras Falcao, Maria Jose., Andrade Machado, Lyeghyna Karla., Leal Bevilaqua, Claudia Maria., Sousa Costa, Igor Rafael., Pompeu de Sousa Brasil, Nilce Viana Gramosa., de Andrade Junior, Heitor Franco. Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil . Revista da sociedade brasileira de medicina tropical, 2011, vol. 44, no. 5, p. 567-571. DOI
Hopp, DC., Alali, FQ., Gu, ZM., McLaughlin, JL. Mono-THF ring annonaceous acetogenins from Annona squamosa. Phytochemistry, 1998, vol. 47, no. 5, p. 803-809. DOI
Bonneau, Natacha., Baloul, Lamia., Ndob, Idensi Bajin Ba., Senejoux, Francois., Champy, Pierre. The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC-MS/MS analysis . Food chemistry, 2017, vol. 226, p. 32-40. DOI
Hopp, DC., Zeng, L., Gu, ZM., Kozlowski, JF., McLaughlin, JL. Novel mono-tetrahydrofuran ring acetogenins, from the bark of Annona squamosa, showing cytotoxic selectivities for the human pancreatic carcinoma cell line, PACA-2 . Journal of natural products, 1997, vol. 60, no. 6, p. 581-586. DOI
Hopp, DC., Alali, FQ., Gu, ZM., McLaughlin, JL. Three new bioactive bis-adjacent THF-ring acetogenins from the bark of Annona squamosa . Bioorganic & medicinal chemistry, 1998, vol. 6, no. 5, p. 569-575. DOI
Xie, HH., Wei, XY., Wang, JD., Liu, MF., Yang, RZ. A new cytotoxic acetogenin from the seeds of Annona squamosa. Chinese chemical letters, 2003, vol. 14, no. 6, p. 588-590.
Chen, Yong., Chen, Jian-wei., Li, Xiang. Cytotoxic Bistetrahydrofuran Annonaceous Acetogenins from the Seeds of Annona squamosa . Journal of natural products, 2011, vol. 74, no. 11, p. 2477-2481. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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