Botanical species · safety record

Argania spinosa

The EFSA Compendium of Botanicals holds 13 constituent measurements and 3 adverse-effect records for Argania spinosa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Argania spinosa (L.) Skeels

13Constituent measurements

3Safety records

7Cited sources

14Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 14 licensed products naming Argania spinosa as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Argania spinosa - seed oil
Leaf
Seed
Seed oil
Seed(s)
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
(-)-camphor	Leaves	Essential oil	≤ 8.6 Percent	GC-MS	Resolve DOI
(-)-camphor	Leaves	Essential oil	≥ 1.5 Percent	GC-MS	Resolve DOI
Myrcene	Leaves	Essential oil	≥ 0.9 Percent	GC-MS	Resolve DOI
Myrcene	Leaves	Essential oil	≤ 5.8 Percent	GC-MS	Resolve DOI
Pentacyclic triterpene saponins	Bark	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Pentacyclic triterpene saponins	Husk	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Pentacyclic triterpene saponins	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Pentacyclic triterpene saponins	Fruit unspecified	Solvent extraction	—	LC-MS	Resolve DOI
Pentacyclic triterpene saponins	Fruit unspecified	Solvent extraction	—	LC-MS	Resolve DOI
3,4-dihydroxybenzoic acid	Fruit unspecified	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier
4-hydroxybenzaldehyde	Fruit unspecified	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier
Gallic acid	Fruit unspecified	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier
P-coumaric acid	Fruit unspecified	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital: kidneys	Unspecified	Solvent extraction	Rat (as animal)	Chronic/long term toxicity	No resolvable identifier
Nephrotoxicity	Urogenital: kidneys	Unspecified	Solvent extraction	Rat (as animal)	Chronic/long term toxicity	No resolvable identifier
Not reported	—	Unspecified	Solvent extraction	Rat (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Alaoui, Katim., Belabbes, Mohamed., Cherrah, Yahia., Hassar, Mohamed., Charrouf, Zoubida., Amarouch, Hamid., Roquebert, Jacques. Acute and chronic toxicity of saponins of Argania spinosa. Annales pharmaceutiques francaises, 1998, vol. 56, no. 5, p. 213-219.
El Amrani, Abdelaziz., Cayuela Sanchez, Jose Antonio., Jamal Eddine, Jamal. Chemical Composition of Moroccan Argania spinosa leaf Essential Oils Isolated by Supercritical CO2, Microwave and Hydrodistillation . Journal of essential oil bearing plants, 2015, vol. 18, no. 5, p. 1138-1147. DOI
Khallouki, Farid., Haubner, Roswitha., Ricarte, Irvila., Erben, Gerhard., Klika, Karel., Ulrich, Cornelia M., Owen, Robert W. Identification of polyphenolic compounds in the flesh of Argan (Morocco) fruits. Food chemistry, 2015, vol. 179, p. 191-198.
El Fakhar, Nadia., Charrouf, Zoubida., Coddeville, Bernadette., Leroy, Yves., Michalski, Jean Claude., Guillaume, Dominique. New triterpenoid saponins from Argania spinosa. Journal of natural medicines, 2007, vol. 61, no. 4, p. 375-380. DOI
Alaoui, A., Charrouf, Z., Soufiaoui, M., Carbone, V., Malorni, A., Pizza, C., Piacente, S. Triterpenoid saponins from the shells of Argania spinosa seeds. Journal of agricultural and food chemistry, 2002, vol. 50, no. 16, p. 4600-4603. DOI
CHARROUF, Z., WIERUSZESKI, JM., FKIHTETOUANI, S., LEROY, Y., CHARROUF, M., FOURNET, B. TRITERPENOID SAPONINS FROM ARGANIA-SPINOSA. Phytochemistry, 1992, vol. 31, no. 6, p. 2079-2086. DOI
Henry, Max., Kowalczyk, Mariusz., Maldini, Mariateresa., Piacente, Sonia., Stochmal, Anna., Oleszek, Wieslaw. Saponin Inventory from Argania spinosa Kernel Cakes by Liquid Chromatography and Mass Spectrometry . Phytochemical analysis, 2013, vol. 24, no. 6, p. 616-622. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature