Botanical species · safety record

Aristolochia clematitis

The EFSA Compendium of Botanicals holds 9 constituent measurements, 1 adverse-effect record and 2 genotoxicity assays for Aristolochia clematitis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Aristolochia clematitis L.

9Constituent measurements

3Safety records

6Cited sources

12Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 12 licensed products naming Aristolochia clematitis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Aristolochia	Roots and other underground parts	Solvent extraction	0.84 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Aristolochia	Roots and other underground parts	—	0.739 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Aristolochia	Aerial part of plants	—	0.192 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Aristolochia	Seed	Solvent extraction	0.65 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Corytuberine	Aerial part of plants	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Corytuberine	Roots and other underground parts	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Magnoflorine	Roots and other underground parts	Solvent extraction	0.14 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
P-coumaric acid	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Sesquiterpene lactones	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital	Seed	Drying (dehydration)	Rabbit (as animal)	Chronic/long term toxicity	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	mammalian cell gene mutation assay	Other	No data	No resolvable identifier
Positive	gene mutation	bacterial gene mutation assay	Bacteria (as organism)	With and without	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Slavik, Jiri., Bochorakova, Jitka., Slavikova, Leonora. Occurrence of magnoflorine and corytuberine in some wild or cultivated plants of Czechoslovakia. Collection of czechoslovak chemical communications, 1987, vol. 52, no. 3, p. 804-11.
Teweldeberhan, Elisabeth., Klepper, Aaron., Krieger, Kristine., Berg, Kerstin., Schrenk, Dieter. Evaluation of the mutagenic potential of an ethanolic extract of Aristolochia clematitis seeds . Naunyn-schmiedebergs archives of pharmacology, 2014, vol. 387, p. S29-S29.
KOSTALOVA, D., HROCHOVA, V., PRONAYOVA, N., LESKO, J. CONSTITUENTS OF ARISTOLOCHIA-CLEMATITIS L. Chemical papers, 1991, vol. 45, no. 5, p. 713-716.
Tamas, M., Fagarasan, E., Mandrutau, I., Oprean, R., Marghitas, LA. Identification and quantitative determination of aristolochic acid from birthwort (Aristolochia clematitis, Aristolochiaceae) . Bulletin of the university of agricultural sciences and veterinary medicine, vol 60: agriculture, 2004, vol. 60, p. 42-47.
Hranjec, T., Kovac, A., Kos, J., Mao, WY., Chen, JJ., Grollman, AP., Jelakovic, B. Endemic nephropathy: the case for chronic poisoning by Aristolochia. Croatian medical journal, 2005, vol. 46, no. 1, p. 116-125.
Pavlovic, N.M. Balkan endemic nephropathy - Current status and future perspectives. Clinical kidney journal, 2013, vol. 6, no. 3, p. 257-265. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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