Botanical species · safety record

Aristolochia contorta

The EFSA Compendium of Botanicals holds 16 constituent measurements and 1 adverse-effect record for Aristolochia contorta. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Aristolochia contorta Bunge

16Constituent measurements

1Safety records

7Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Aristolactam	Unspecified	Solvent extraction	—	HPLC-DAD	Resolve DOI
Aristolochia	Unspecified	Solvent extraction	≤ 5.31 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolochia	Unspecified	Solvent extraction	≥ 2.07 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolochia	Fruit unspecified	Solvent extraction	1.129 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Phenanthrenes	Live plants	Solvent extraction	—	HPLC-UV	Resolve DOI
Aporphine alkaloids	Roots and other underground parts	Solvent extraction	—	Unspecified	No resolvable identifier
Aristolactam	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Aristolactam	Unspecified	Solvent extraction	≤ 933.9 Microgram/gram	LC-MS/MS	No resolvable identifier
Aristolactam	Unspecified	Solvent extraction	≥ 861.7 Microgram/gram	LC-MS/MS	No resolvable identifier
Aristolochia	Unspecified	Solvent extraction	≥ 639.9 Microgram/gram	LC-MS/MS	No resolvable identifier
Aristolochia	Unspecified	Solvent extraction	≤ 669.3 Microgram/gram	LC-MS/MS	No resolvable identifier
Aristolochia	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Esculetin	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Magnocurarine	Seed	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Magnoflorine	Seed	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
P-coumaric acid	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital: kidneys	Fruit unspecified	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Yuan, Jinbin., Liu, Qian., Zhu, Weifeng., Ding, Li., Tang, Fei., Yao, Shouzhuo. Simultaneous analysis of six aristolochic acids and five aristolactams in herbal plants and their preparations by high-performance liquid chromatography-diode array detection-fluorescence detection . Journal of chromatography a, 2008, vol. 1182, no. 1, p. 85-92. DOI
Wei, F., Cheng, XL., Ma, LY., Jin, WT., Schaneberg, BT., Khan, IA., Lin, RC. Analysis of aristolochic acids and analogues in medicinal plants and their commercial products by HPLC-PAD-ESI/MS . Phytochemical analysis, 2005, vol. 16, no. 3, p. 222-230. DOI
Zhang, CY., Wang, X., Su, T., Ma, CM., Wen, YJ., Shang, MY., Li, XM., Liu, GX., Cai, SQ. New aristolochic acid, aristololactam and renal cytotoxic constituents from the stem and leaves of Aristolochia contorta . Pharmazie, 2005, vol. 60, no. 10, p. 785-788.
Mao Wen-Wen., Gao Wen., Liang Zhi-Tao., Li Ping., Zhao Zhong-Zhen., Li Hui-Jun. Characterization and quantitation of aristolochic acid analogs in different parts of Aristolochiae Fructus, using UHPLCQ/TOF-MS and UHPLC-QqQ-MS . Chinese journal of natural medicines, 2017, vol. 15, no. 5, p. 392-400.
Yuan, J.-B., Huang, Q., Ren, G., Shi, M., Chen, L., Yang, W.-L., Chen, H.-F., Yang, M., Yang, B., Yang, G.-H., Luo, X.-Q. Acute and subacute toxicity of the extract of Aristolochiae Fructus and honey-fried Aristolochiae Fructus in rodents. Biological and pharmaceutical bulletin, 2014, vol. 37, no. 3, p. 387-393. DOI
Lee, Heum Sook., Han, Dae Suk., Won, Dug Kwon. Studies on the constituents of the root of Aristolochia contorta. (II). Oxoaporphines. Saengyak hakhoechi, 1990, vol. 21, no. 1, p. 52-5.
Hu, Yong., Wu, Hai-Long., Yin, Xiao-Li., Gu, Hui-Wen., Xiao, Rong., Wang, Li., Fang, Huan., Yu, Ru-Qin. Interference-free spectrofluorometric quantification of aristolochic acid I and aristololactam I in five Chinese herbal medicines using chemical derivatization enhancement and second-order calibration methods. Spectrochimica acta, part a: molecular and biomolecular spectroscopy, 2017, vol. 175, p. 229-238.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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