Botanical species · safety record

Aristolochia debilis

The EFSA Compendium of Botanicals holds 20 constituent measurements, 2 adverse-effect records and 1 genotoxicity assay for Aristolochia debilis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Aristolochia debilis Siebold & Zucc.

20Constituent measurements

3Safety records

6Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Aristolactam	Unspecified	Solvent extraction	0.285 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolactam	Fruit peel	Solvent extraction	≤ 0.509 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolactam	Fruit peel	Solvent extraction	≥ 0.027 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolactam	Fruit peel	Solvent extraction	≤ 0.046 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolactam	Fruit peel	Solvent extraction	≥ 0.017 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolactam	Unspecified	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Aristolochia	Unspecified	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Aristolochia	Fruit unspecified	—	—	—	Resolve DOI
Aristolochia	Fruit peel	Solvent extraction	≤ 0.872 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolochia	Fruit peel	Solvent extraction	≥ 0.382 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolochia	Fruit peel	Solvent extraction	≤ 1.179 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolochia	Fruit peel	Solvent extraction	≥ 0.369 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolochia	Fruit peel	Solvent extraction	≤ 0.524 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolochia	Fruit peel	Solvent extraction	≥ 0.064 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolochia	Fruit peel	Solvent extraction	≤ 1.41 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolochia	Fruit peel	Solvent extraction	≥ 0.299 Milligram/gram	HPLC-DAD	Resolve DOI
Aristolochia	Unspecified	Solvent extraction	4.265 Milligram/gram	HPLC-DAD	Resolve DOI
Fangchinoline	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Magnoflorine	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Tetrandrine	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital: kidneys	—	Solvent extraction	Rat (as animal)	Subchronic	No resolvable identifier
Nephrotoxicity	Urogenital: kidneys	—	Solvent extraction	Rat (as animal)	Subchronic	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	—	bacterial reverse mutation assay	Bacteria (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Song, Li-Qun., Ma, Xiao-Peng., Wang, Li-Zhe., Qiao, Yu., Song, Ye-Xu., Ma, Yan-Chun. The water decoction of Aristolochia debilis Sieb.et Zucc induces renal toxic effects in rats . African journal of pharmacy and pharmacology, 2010, vol. 4, no. 1, p. 8-12.
Zhou, J., Ouedraogo, M., Qu, F., Duez, P. Potential genotoxicity of traditional Chinese medicinal plants and phytochemicals: An overview. Phytotherapy Research, 2013, vol. 27, no. 12, p. 1745-1755. DOI
Yuan, Jinbin., Liu, Qian., Zhu, Weifeng., Ding, Li., Tang, Fei., Yao, Shouzhuo. Simultaneous analysis of six aristolochic acids and five aristolactams in herbal plants and their preparations by high-performance liquid chromatography-diode array detection-fluorescence detection . Journal of chromatography a, 2008, vol. 1182, no. 1, p. 85-92. DOI
Xu, Yu-Qiong., Li, Xiao-Wei., Liu, Guang-Xue., Wang, Xuan., Shang, Ming-Ying., Li, Xiao-Mei., Cai, Shao-Qing. Comparative study of the contents of analogues of aristolochic acid in two kinds of Aristolochiae Fructus by high-performance liquid chromatography . Journal of natural medicines, 2013, vol. 67, no. 1, p. 113-122. DOI
Kong, D., Gao, H., Li, X., Lu, J., Yuan, D. Rapid determination of eight aristolochic acid analogues in five Aristolochiaceae plants by ultra-high performance liquid chromatography quadrupole/time-of-flight mass spectrometry. Journal of chinese pharmaceutical sciences, 2015, vol. 24, no. 6, p. 364-375. DOI
Ruecker, G., Mayer, R. Bisbenzylisoquinoline alkaloids from roots of Aristolochia debilis. Planta medica, 1985, vol. (2), p. 183-4.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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