Botanical species · safety record

Aristolochia fangchi

The EFSA Compendium of Botanicals holds 16 constituent measurements and 4 adverse-effect records for Aristolochia fangchi. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Aristolochia fangchi Y.C.Wu ex L.D.Chow & S.M.Hwang

16Constituent measurements

4Safety records

6Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Aristolochia	Unspecified	Solvent extraction	≥ 0.1 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Aristolochia	Unspecified	Solvent extraction	≤ 0.4 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Magnoflorine	Unspecified	Solvent extraction	≥ 0.17 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Magnoflorine	Unspecified	Solvent extraction	≤ 0.27 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Acutumine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Alkaloids	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aristolactam	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aristolochia	Roots and other underground parts	Solvent extraction	36.42 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aristolochia	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aristolochia	Roots and other underground parts	Solvent extraction	15.1 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Berbamine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Fangchinoline	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Isotetrandrine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Magnoflorine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Sinomenine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Tetrandrine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital	Roots and other underground parts	—	Human (as organism)	Case report	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	—	Solvent extraction	Rat (as animal)	Subchronic	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	—	—	Rat (as animal)	Acute toxicity	No resolvable identifier
Nephrotoxicity	Urogenital: kidneys	—	—	Rat (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Schmeiser, Heinz H., Nortier, Joelle L., Singh, Rajinder., da Costa, Goncalo Gamboa., Sennesael, Jacques., Cassuto-Viguier, Elisabeth., Ambrosetti, Damien., Rorive, Sandrine., Pozdzik, Agnieszka., Phillips, David H., Stiborova, Marie., Arlt, Volker M. Exceptionally long- term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy . International journal of cancer, 2014, vol. 135, no. 2, p. 502-507. DOI
Zhao, Zhong-Zhen., Liang, Zhi-Tao., Jiang, Zhi-Hong., Leung, Kelvin Sze-Yin., Chan, Chi-Leung., Chan, Hon-Yee., Sin, Jaime., Man, Tim-On., Law, Kwok-Wai. Comparative study on the aristolochic acid I content of Herba Asari for safe use. Phytomedicine, 2008, vol. 15, no. 9, p. 741-748.
Liang, Qi., Ni, Cheng., Xie, Ming., Zhang, Qi., Zhang, Yan-Xia., Yan, Xian-Zhong., Yang, Mei-Juan., Peng, Shuang-Qing., Zhang, Yu-Zhong. Nephrotoxicity study of Aristolochia fangchi in rats by metabonomics .. Zhong xi yi jie he xue bao = journal of chinese integrative medicine, 2009, vol. 7, no. 8, p. 746-52. DOI
Liu, Sha., Du, Guiyou., Li, Li., Xiao, Yongqing. Toxicokinetics and distribution of Aristolochia Fangchi in rats. Zhongyao yaoli yu linchuang, 2006, vol. 22(3-4), p. 90-94.
Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . Journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357-367.
Sim, Hee-Jung., Kim, Ji Hee., Lee, Kang Ro., Hong, Jongki. Simultaneous Determination of Structurally Diverse Compounds in Different Fangchi Species by UHPLC-DAD and UHPLC-ESI-MS/MS . Molecules, 2013, vol. 18, no. 5, p. 5235-5250. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature