Botanical species · safety record

Aristolochia manshuriensis

The EFSA Compendium of Botanicals holds 6 constituent measurements, 6 adverse-effect records and 2 genotoxicity assays for Aristolochia manshuriensis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Aristolochia manshuriensis Kom.

6Constituent measurements

8Safety records

5Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Aristolochia	Stem / stalk	Solvent extraction	0.5 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aristolochia	Stem / stalk	Solvent extraction	2.85 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aristolochia	Unspecified	Powder	0.854 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aristolochia	Unspecified	Powder	0.521 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aristolochia	Unspecified	Powder	3.25 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aristolochia	Unspecified	Powder	1.04 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Urogenital: kidneys	Stem / stalk	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI
Not stated	Urogenital: kidneys	Stem / stalk	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Unspecified	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Nephrotoxicity	Urogenital: kidneys	Unspecified	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Systemic	Urogenital	Unspecified	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Systemic	Urogenital	Unspecified	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	With and without	Resolve DOI
Positive	DNA damage and/or repair	Mammalian erythrocyte micronucleus test	House mouse (as animal)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Qiu, Q., Liu, ZH., Chen, HP., Yin, HL., Li, LS. Long-term outcome of acute renal injury induced by Aristolochia manshuriensis Kom in rats . Acta pharmacologica sinica, 2000, vol. 21, no. 12, p. 1129-1135.
Hwang, Youn-Hwan., Kim, Taesoo., Cho, Won-Kyung., Yang, Hye Jin., Kwak, Dong Hoon., Ha, Hyunil., Song, Kwang Hoon., Ma, Jin Yeul. In Vitro and In Vivo Genotoxicity Assessment of Aristolochia manshuriensis Kom. . Evidence-based complementary and alternative medicine : ecam, 2012, vol. 2012, p. 412736-412736. DOI
Yuan, Jinbin., Liu, Qian., Zhu, Weifeng., Ding, Li., Tang, Fei., Yao, Shouzhuo. Simultaneous analysis of six aristolochic acids and five aristolactams in herbal plants and their preparations by high-performance liquid chromatography-diode array detection-fluorescence detection. Journal of chromatography a, 2008, vol. 1182, no. 1, p. 85-92.
Xue, Xiang., Xiao, Ying., Gong, Likun., Guan, Shuhong., Liu, Yongzhen., Lu, Henglei., Qi, Xinming., Zhang, Yunhai., Li, Yan., Wua, Xiongfei., Ren, Jin. Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice. JOURNAL OF ETHNOPHARMACOLOGY, 2008, vol. 119, no. 1, p. 87-93. DOI
Liu, Man-Chang., Maruyama, Shoichi., Mizuno, Masashi., Morita, Yoshiki., Hanaki, Shigeru., Yuzawa, Yukio., Matsuo, Seiichi. The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. . Clinical and experimental nephrology, 2003, vol. 7, no. 3, p. 186-94. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature