Botanical species · safety record

Arnica montana

The EFSA Compendium of Botanicals holds 12 constituent measurements and 2 adverse-effect records for Arnica montana. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Arnica montana L.

12Constituent measurements

2Safety records

5Cited sources

660Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 660 licensed products naming Arnica montana as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
decoction
fluid

Source material stated

Arnica Montana - flower
Arnica Tincture
Arnica montana
Arnica montana L., dried underground parts
Dried flowers
Dried underground part(s)
Dried underground parts
Entire plant including the root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Guaianolides	Flower	Solvent extraction	—	Gaschromatography (GC)	Resolve DOI
Helenalin	Flower	Solvent extraction	≤ 10.3 Milligram/gram	HPLC with standard detection methods	Resolve DOI
Helenalin	Flower	Solvent extraction	≥ 5.2 Milligram/gram	HPLC with standard detection methods	Resolve DOI
Isotussilagine	Flowering top	Solvent extraction	—	GC-MS	Resolve DOI
Pyrrolizidine alkaloids	Flowering top	Solvent extraction	—	GC-MS	Resolve DOI
Sesquiterpene lactones	Flower	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Sesquiterpene lactones	Flower	Solvent extraction	≤ 18.2 Milligram/gram	HPLC with standard detection methods	Resolve DOI
Sesquiterpene lactones	Flower	Solvent extraction	≥ 10.9 Milligram/gram	HPLC with standard detection methods	Resolve DOI
Tussilagine	Flowering top	Solvent extraction	—	GC-MS	Resolve DOI
Helenalin	Flowering top	Solvent extraction	—	—	No resolvable identifier
Sesquiterpene lactones	Flower	Solvent extraction	≤ 0.9 Percent	HPLC with standard detection methods	No resolvable identifier
Sesquiterpene lactones	Flower	Solvent extraction	≥ 0.3 Percent	HPLC with standard detection methods	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Flower	Solvent extraction	House mouse (as animal)	Acute toxicity	No resolvable identifier
Hepatotoxicity	Liver	Flower	Solvent extraction	Hamster (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kos, O., Lindenmeyer, MT., Tubaro, A., Sosa, S., Merfort, I. New sesquiterpene lactones from arnica tincture prepared from fresh flowerheads of Arnica montana . Planta medica, 2005, vol. 71, no. 11, p. 1044-1052. DOI
Perry, Nigel B., Burgess, Elaine J., Rodriguez Guitian, Manuel A., Romero Franco, Rosa., Lopez Mosquera, Elvira., Smallfield, Bruce M., Joyce, Nigel I., Littlejohn, Roger P. Sesquiterpene Lactones in Arnica montana: Helenalin and Dihydrohelenalin Chemotypes in Spain . Planta medica, 2009, vol. 75, no. 6, p. 660-666. DOI
Willuhn, G. Arnica Flowers: Pharmacology, Toxicolgy, and Analysis of the Sesquiterpene Lactones - Their Main Active Substances. Acs symposium series, 1998, vol. 691, p. 118-132.
PASSREITER, CM., WILLUHN, G., RODER, E. TUSSILAGINE AND ISOTUSSILAGINE - 2 PYRROLIZIDINE ALKALOIDS IN THE GENUS ARNICA . Planta medica, 1992, vol. 58, no. 6, p. 556-557. DOI
[Anonymous]. Final report on the safety assessment of Arnica montana extract and Arnica montana. . International journal of toxicology, 2001, vol. 20 Suppl 2, p. 1-11.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature