Botanical species · safety record

Artemisia absinthium

The EFSA Compendium of Botanicals holds 36 constituent measurements, 5 adverse-effect records and 1 genotoxicity assay for Artemisia absinthium. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Artemisia absinthium L.

36Constituent measurements

6Safety records

9Cited sources

106Licensed products (Canada)

Also recorded as

Absinthium officinale Brot.
Artemisia vulgare Lam.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 106 licensed products naming Artemisia absinthium as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
fluid

Source material stated

Aerial herb
Aerial parts
Essential oil from leaf
Flower
Flowering plant
Flowers
Flowers and leaves
Fresh above ground parts

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
(-)-camphor	Aerial part of plants	Essential oil	1.4 Percent	GC-MS	Resolve DOI
1,8-cineole	Aerial part of plants	Essential oil	1.5 Percent	GC-MS	Resolve DOI
Alpha-thujone	Aerial part of plants	Essential oil	≥ 0.2 Percent	GC-FID-MS	Resolve DOI
Beta-thujone	Aerial part of plants	Essential oil	≥ 0.4 Percent	GC-FID-MS	Resolve DOI
1,8-cineole	Aerial part of plants	Essential oil	≤ 5.3 Percent Area	GC-MS	No resolvable identifier
1,8-cineole	Aerial part of plants	Essential oil	≥ 2.2 Percent	GC-MS	No resolvable identifier
1,8-cineole	Aerial part of plants	Essential oil	≤ 14.9 Percent	GC-MS	No resolvable identifier
1,8-cineole	Aerial part of plants	Essential oil	≥ 0.1 Percent	GC-FID-MS	No resolvable identifier
1,8-cineole	Aerial part of plants	Essential oil	≤ 5.2 Percent	GC-FID-MS	No resolvable identifier
1,8-cineole	Aerial part of plants	Essential oil	≥ 4.9 Percent Area	GC-MS	No resolvable identifier
Absinthin	Live plants	Solvent extraction	—	Unspecified	No resolvable identifier
Alkaloids	Leaves	Solvent extraction	1.01 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Alkaloids	Live plants	Solvent extraction	—	Unspecified	No resolvable identifier
Alpha-thujone	Aerial part of plants	Essential oil	≥ 2.3 Percent	GC-FID-MS	No resolvable identifier
Alpha-thujone	Aerial part of plants	Essential oil	≤ 23.5 Percent	GC-FID-MS	No resolvable identifier
Beta-thujone	Aerial part of plants	Essential oil	≥ 0.1 Percent	GC-MS	No resolvable identifier
Beta-thujone	Aerial part of plants	Essential oil	≤ 17.4 Percent	GC-MS	No resolvable identifier
Beta-thujone	Aerial part of plants	Essential oil	≥ 0.2 Percent	GC-FID-MS	No resolvable identifier
Beta-thujone	Aerial part of plants	Essential oil	≤ 30.7 Percent	GC-FID-MS	No resolvable identifier
Cyanogenic glycosides	Leaves	Solvent extraction	0.52 Microgram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Monoterpene ketones	Aerial part of plants	Essential oil	≥ 11.1 Percent Area	GC-MS	No resolvable identifier
Monoterpene ketones	Aerial part of plants	Essential oil	≤ 12.3 Percent Area	GC-MS	No resolvable identifier
Myrcene	Aerial part of plants	Essential oil	≥ 1.7 Percent	GC-MS	No resolvable identifier
Myrcene	Aerial part of plants	Essential oil	≤ 20.3 Percent	GC-MS	No resolvable identifier
Myrcene	Aerial part of plants	Essential oil	≥ 1 Percent	GC-FID-MS	No resolvable identifier
Myrcene	Aerial part of plants	Essential oil	≤ 9.2 Percent	GC-FID-MS	No resolvable identifier
Myrcene	Aerial part of plants	Essential oil	≥ 2 Percent Area	GC-MS	No resolvable identifier
Myrcene	Aerial part of plants	Essential oil	≤ 6 Percent Area	GC-MS	No resolvable identifier
Myristicin	Aerial part of plants	Essential oil	≥ 0.1 Percent	GC-MS	No resolvable identifier
Myristicin	Aerial part of plants	Essential oil	≤ 1.1 Percent	GC-MS	No resolvable identifier
P-coumaric acid	Aerial part of plants	Solvent extraction	≥ 16 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
P-coumaric acid	Aerial part of plants	Solvent extraction	≤ 22.8 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Saponins	Leaves	Solvent extraction	3.9 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Sesquiterpene lactones	Live plants	Solvent extraction	—	Unspecified	No resolvable identifier
Tannins	Leaves	Solvent extraction	1.4 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Tannins	Live plants	Solvent extraction	—	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Brain	Aerial part of plants	—	House mouse (as animal)	Acute toxicity	Resolve DOI
Neurotoxicity	Brain	Aerial part of plants	—	Rat (as animal)	Chronic/long term toxicity	Resolve DOI
Neurotoxicity	Brain	Aerial part of plants	—	House mouse (as animal)	Acute toxicity	Resolve DOI
Other toxicities	—	Live plants	Solvent extraction	House mouse (as animal)	Acute toxicity	No resolvable identifier
Other toxicities	—	Live plants	Solvent extraction	House mouse (as animal)	Acute toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	in vitro mammalian chromosome aberration test	House mouse (as animal)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Yousef Alshibly, N.M. Effect of Artemisia absinthium L. on genotoxicity on mice bone marrow cells. World applied sciences journal, 2014, vol. 30, no. 6, p. 770-777. DOI
Judzentiene, Asta., Budiene, Jurga., Gircyte, Renata., Masotti, Veronique., Laffont-Schwob, Isabelle. Toxic Activity and Chemical Composition of Lithuanian Wormwood (Artemisia absinthium L.) Essential Oils . Records of natural products, 2012, vol. 6, no. 2, p. 180-183.
Biradi, Mahesh., Hullatti, Kirankumar. Screening of Indian medicinal plants for cytotoxic activity by brine shrimp lethality (BSL) assay and evaluation of their total phenolic content. Drug development and therapeutics, 2014, vol. 5, no. 2, p. 139-144.
Jaramillo Jaramillo, Carmita., Jaramillo Espinoza, Anyi., D'Armas, Haydelba., Troccoli, Luis., Rojas de Astudillo, Luisa. Concentrations of alkaloids, cyanogenic glycosides, polyphenols and saponins in selected medicinal plants from Ecuador and their relationship with acute toxicity against Artemia salina . Revista de biologia tropical, 2016, vol. 64, no. 3, p. 1171-1184.
Pelkonen, Olavi., Abass, Khaled., Wiesner, Jacqueline. Thujone and thujone-containing herbal medicinal and botanical products: Toxicological assessment . Regulatory toxicology and pharmacology, 2013, vol. 65, no. 1, p. 100-107. DOI
Judzentiene, Asta., Tomi, Felix., Casanova, Joseph. Analysis of Essential Oils of Artemisia absinthium L. from Lithuania by CC, GC(RI), GC-MS and C-13 NMR . Natural product communications, 2009, vol. 4, no. 8, p. 1113-1118.
Geszprych, A., Przybyl, J. L., Kuczerenko, A., Weglarz, Z., Mathe, A., Barata, AM., Carlen, C., Craker, L. Diversity of Wormwood (Artemisia absinthium L.) Growing Wild in Poland in Respect of the Content and Composition of Essential Oil and Phenolic Compounds . Xxviii international horticultural congress on science and horticulture for people (ihc2010): a new look at medicinal and aromatic plants seminar, 2011, vol. 925, p. 123-129.
Logarto Parra, A., Silva Yhebra, R., Guerra Sardinas, I., Iglesias Buela, L. Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. . Phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, vol. 8, no. 5, p. 395-400.
Kordali, S., Aslan, I., Calmasur, O., Cakir, A. Toxicity of essential oils isolated from three Artemisia species and some of their major components to granary weevil, Sitophilus granarius (L.) (Coleoptera : Curculionidae) . Industrial crops and products, 2006, vol. 23, no. 2, p. 162-170. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature