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Botanical species · safety record

Asimina triloba

The EFSA Compendium of Botanicals holds 18 constituent measurements for Asimina triloba. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Asimina triloba (L.) Dunal

18Constituent measurements
0Safety records
12Cited sources
4Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 4 licensed products naming Asimina triloba as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

  • Dry

Source material stated

  • New material
  • Ripe grain

What the records describe

Constituents measured

  • Acetogenins12
  • Annonacin2
  • Asimilobine1
  • Asimin1
  • Asiminacin1
  • Syringaresinol1

Plant parts

  • Seed10
  • Bark5
  • Fruit unspecified2
  • Fruit peel1

Preparations

  • Solvent extraction18

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsFruit peelSolvent extraction0.0701 Milligram/gramNuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsBarkSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsBarkSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsBarkSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AnnonacinSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AsimilobineSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AsiminSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AsiminacinSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
SyringaresinolBarkSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
AcetogeninsSeedSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
AcetogeninsBarkSolvent extraction—UnspecifiedNo resolvable identifier
AcetogeninsFruit unspecifiedSolvent extraction0.162 Milligram/gramLC-HR-MSNo resolvable identifier
AnnonacinFruit unspecifiedSolvent extraction7.72 Milligram/gramLC-HR-MSNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Woo, MH., Kim, DH., McLaughlin, JL. Asitrilobins A and B: cytotoxic mono-THF Annonaceous acetogenins from the seeds of Asimina triloba . Phytochemistry, 1999, vol. 50, no. 6, p. 1033-1040. DOI
  2. WOO, MH., ZENG, L., YE, Q., GU, ZM., ZHAO, GX., MCLAUGHLIN, JL. 16,19-CIS-MURISOLIN AND MURISOLIN-A, 2 NOVEL BIOACTIVE MONO-TETRAHYDROFURAN ANNONACEOUS ACETOGENINS FROM ASIMINA-TRILOBA SEEDS . Bioorganic & medicinal chemistry letters, 1995, vol. 5, no. 11, p. 1135-1140. DOI
  3. Potts, Lisa F., Luzzio, Frederick A., Smith, Scott C., Hetman, Michal., Champy, Pierre., Litvan, Irene. Annonacin in Asimina triloba fruit: Implication for neurotoxicity. Neurotoxicology, 2012, vol. 33, no. 1, p. 53-58. DOI
  4. Zhao, GX., Chao, JF., Zeng, L., Rieser, MJ., McLaughlin, JL. The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba . Bioorganic & medicinal chemistry, 1996, vol. 4, no. 1, p. 25-32. DOI
  5. WOO, MH., ZENG, L., MCLAUGHLIN, JL. ASITRIBIN AND ASIMINENIN-A AND ASIMINENIN-B, NOVEL BIOACTIVE ANNONACEOUS ACETOGENINS FROM THE SEEDS OF ASIMINA-TRILOBA . Heterocycles, 1995, vol. 41, no. 8, p. 1731-1742.
  6. Woo, MH., Chung, SO., Kim, DH. Asitrilobins C and D: Two new cytotoxic mono-tetrahydrofuran annonaceous acetogenins from Asimina triloba seeds . Bioorganic & medicinal chemistry, 2000, vol. 8, no. 1, p. 285-290. DOI
  7. ZHAO, GX., NG, JH., KOZLOWZKI, JF., SMITH, DL., MCLAUGHLIN, JL. BULLATIN AND BULLANIN - 2 NOVEL, HIGHLY CYTOTOXIC ACETOGENINS FROM ASIMINA-TRILOBA . Heterocycles, 1994, vol. 38, no. 8, p. 1897-1908.
  8. Kim, EJ., Tian, F., Woo, MH. Asitrocin, (2,4)-cis- and trans-asitrocinones: Novel bioactive mono-tetrahydrofuran acetogenins from Asimina triloba seeds . Journal of natural products, 2000, vol. 63, no. 11, p. 1503-1506. DOI
  9. Woo, MH., Cho, KY., Zhang, Y., Zeng, L., Gu, ZM., McLaughlin, JL. Asimilobin and cis- and trans-murisolinones, novel bioactive annonaceous acetogenins from the seeds of Asimina triloba . Journal of natural products, 1995, vol. 58, no. 10, p. 1533-1542. DOI
  10. Levine Robert A., Richards Kristy M., Tran Kevin., Luo Rensheng., Thomas Andrew L., Smith Robert E. Determination of Neurotoxic Acetogenins in Pawpaw (Asimina triloba) Fruit by LC-HRMS. Journal of agricultural and food chemistry, 2015, p. Journal of agricultural and food chemistry (2015).
  11. He, K., Zhao, GX., Shi, G., Zeng, L., Chao, JF., McLaughlin, JL. Additional bioactive annonaceous acetogenins from Asimina triloba (Annonaceae) . Bioorganic & medicinal chemistry, 1997, vol. 5, no. 3, p. 501-506. DOI
  12. ZHAO, GX., HUI, YH., RUPPRECHT, JK., MCLAUGHLIN, JL., WOOD, KV. ADDITIONAL BIOACTIVE COMPOUNDS AND TRILOBACIN, A NOVEL HIGHLY CYTOTOXIC ACETOGENIN, FROM THE BARK OF ASIMINA-TRILOBA . Journal of natural products, 1992, vol. 55, no. 3, p. 347-356. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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