Botanical species · safety record
Aspidosperma quebracho-blanco
The EFSA Compendium of Botanicals holds 24 constituent measurements and 1 adverse-effect record for Aspidosperma quebracho-blanco. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Aspidosperma quebracho-blanco Schltdl.
Regulatory presence
Health Canada's Licensed Natural Health Products Database holds 5 licensed products naming Aspidosperma quebracho-blanco as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.
Source material stated
What the records describe
Constituents measured
- Aspidospermine4
- Alkaloids3
- Aspidospermatin3
- Indole alkaloids3
- Quebrachamine3
- Quebrachidine2
- Tannins2
- Yohimbine2
- Aspidospermatidine1
- N-methylaspidospermatidine1
Plant parts
- Bark11
- Unspecified8
- Leaves6
Preparations
- Solvent extraction14
Effect types
- Neurotoxicity1
Target tissues
- Neurologic: central nervous system1
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Alkaloids | Bark | Solvent extraction | — | GC-MS | Resolve DOI |
| Alkaloids | Leaves | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Aspidospermatidine | Bark | Solvent extraction | — | GC-MS | Resolve DOI |
| Aspidospermatin | Bark | Solvent extraction | — | GC-MS | Resolve DOI |
| Aspidospermine | Bark | Solvent extraction | — | GC-MS | Resolve DOI |
| Aspidospermine | Leaves | Solvent extraction | — | IR and Raman Spectroscopy | Resolve DOI |
| Quebrachamine | Bark | Solvent extraction | — | GC-MS | Resolve DOI |
| Quebrachidine | Leaves | Solvent extraction | — | IR and Raman Spectroscopy | Resolve DOI |
| Yohimbine | Bark | Solvent extraction | — | GC-MS | Resolve DOI |
| Alkaloids | Bark | Solvent extraction | — | Standard Chromatographic tests (paper- thin layer- and column chromatography) | No resolvable identifier |
| Aspidospermatin | Unspecified | — | — | Unspecified | No resolvable identifier |
| Aspidospermatin | Unspecified | — | — | Unspecified | No resolvable identifier |
| Aspidospermine | Bark | — | — | Mass Spectroscopy and hyphenated methods without chromatography | No resolvable identifier |
| Aspidospermine | Unspecified | — | — | Unspecified | No resolvable identifier |
| Indole alkaloids | Bark | Solvent extraction | — | GC-MS | No resolvable identifier |
| Indole alkaloids | Unspecified | — | — | Unspecified | No resolvable identifier |
| Indole alkaloids | Unspecified | — | — | Unspecified | No resolvable identifier |
| N-methylaspidospermatidine | Unspecified | — | — | Unspecified | No resolvable identifier |
| Quebrachamine | Bark | — | — | Mass Spectroscopy and hyphenated methods without chromatography | No resolvable identifier |
| Quebrachamine | Unspecified | — | — | Unspecified | No resolvable identifier |
| Quebrachidine | Unspecified | — | — | Unspecified | No resolvable identifier |
| Tannins | Leaves | Solvent extraction | 1.81 Percent | Unspecified | No resolvable identifier |
| Tannins | Leaves | Solvent extraction | 1.87 Percent | Unspecified | No resolvable identifier |
| Yohimbine | Bark | Solvent extraction | 44 Milligram/100 gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
Recorded adverse effects
Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.
| Effect | Target tissue | Plant part | Preparation | Test organism | Test type | Source |
|---|---|---|---|---|---|---|
| Neurotoxicity | Neurologic: central nervous system | Leaves | — | House mouse (as animal) | Acute toxicity | Resolve DOI |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- BENOIT, PS., ANGRY, G., LYON, RL., FONG, HHS., FARNSWORTH, NR. BIOLOGICAL AND PHYTOCHEMICAL EVALUATION OF PLANTS .13. PRELIMINARY ESTIMATION OF ANALGESIC ACTIVITY OF RHAZINILAM, A NOVEL ALKALOID ISOLATED FROM ASPIDOSPERMA-QUEBRACHO-BLANCO LEAVES . Journal of pharmaceutical sciences, 1973, vol. 62, no. 11, p. 1889-1889. DOI
- BIEMANN, K., SPITELLER, G., SPITELLERFRIEDMANN, M. APPLICATION OF MASS SPECTROMETRY TO STRUCTURE PROBLEMS .10. ALKALOIDS OF BARK OF ASPIDOSPERMA QUEBRACHO BLANCO . Journal of the american chemical society, 1963, vol. 85, no. 5, p. 631-&. DOI
- Schnoes, H.K., Burlingame, A.L., Biemann, K. Application of mass spectrometry to structure problems: the occurrence of eburnamenine and related alkaloids in Rhazya stricta and Aspidosperma quebracho blanco. Tetrahedron letters, 1962, vol. 3, no. 22, p. 993-999.
- Wilson, E., Palacios, P., Rondina, R. V. D., Coussio, J. D. Determination of yohimbine in bark isolated from Aspidosperma quebracho blanco Schlecht. Revista farmaceutica (buenos aires), 1983, vol. 125(1-4), p. 9-11.
- LYON, RL., FONG, HHS., FARNSWORTH, NR., SVOBODA, GH. BIOLOGICAL AND PHYTOCHEMICAL EVALUATION OF PLANTS .9. ISOLATION OF ASPIDOSPERMINE, QUEBRACHIDINE, RHAZINILAM, (-)-PYRIFOLIDINE, AND AKUAMMIDINE FROM ASPIDOSPERMA-QUEBRACHO-BLANCO (APOCYNACEAE) . Journal of pharmaceutical sciences, 1973, vol. 62, no. 2, p. 218-221. DOI
- Biemann, K., Spiteller, G. Application of mass spectrometry to structure problems. VIII. Quebrachamine. Journal of the american chemical society, 1962, vol. 84, p. 4578-86.
- Markey, S., Biemann, Klaus., Witkop, Bernhard. Isolation of rhazidine and akuammidine from Aspidosperma quebracho-blanco. Structure of rhazidine. Tetrahedron letters, 1967, vol. (2), p. 157-60.
- Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. (+)-Aspidospermidine (HMDB30360). Human metabolome database, 2012.
- Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. (+)-Quebrachidine (HMDB30390). Human metabolome database, 2012.
- Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. (-)-Aspidospermine (HMDB30361). Human metabolome database, 2012.
- Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. (-)-Quebrachamine (HMDB30260). Human metabolome database, 2012.
- Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. 14,19-Didehydrocondyfolan (HMDB30356). Human metabolome database, 2012.
- Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. 14,19-Dihydroaspidospermatine (HMDB30359). Human metabolome database, 2012.
- Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. Aspidospermatine (HMDB30358). Human metabolome database, 2012.
- Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. N-Methylaspidospermatidine (HMDB30357). Human metabolome database, 2012.
- Prado, Luis L., Ricci, Enzo. Systematic study of the tannin content of various indigenous species. Anales admin. nacl. bosques, rep. arg., 1956, p. 7-17.
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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