Botanical species · safety record

Atropa belladonna

The EFSA Compendium of Botanicals holds 10 constituent measurements and 7 adverse-effect records for Atropa belladonna. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Atropa belladonna L.

10Constituent measurements

7Safety records

9Cited sources

98Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 98 licensed products naming Atropa belladonna as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Fresh whole flowering plant
Herb
Herb top
Plant
Plante entière
Plante entière début de floraison
Plante entière fleurie fraîche
Plantes fraîches entières sans les sections ligneuses inférieures de la tige récoltées au début de la floraison

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Flower	Solvent extraction	1200 Milligram/kilogram	GC-MS	Resolve DOI
Atropine	Aerial part of plants	Solvent extraction	2 Percent	HPLC with standard detection methods	Resolve DOI
Scopolamine	Aerial part of plants	Solvent extraction	9 Percent	HPLC with standard detection methods	Resolve DOI
Apoatropine	Leaves	Solvent extraction	—	—	No resolvable identifier
Atropine	Roots and other underground parts	Solvent extraction	—	—	No resolvable identifier
Cuscohygrine	Unspecified	—	—	—	No resolvable identifier
Hyoscyamine	Leaves	Solvent extraction	—	—	No resolvable identifier
Scopolamine	Roots and other underground parts	Solvent extraction	—	—	No resolvable identifier
Scopolamine	Leaves	Solvent extraction	—	—	No resolvable identifier
Tropine	Leaves	Solvent extraction	—	—	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic	Fruit unspecified	Fresh	—	Case report	Resolve DOI
Neurotoxicity	Neurologic	Fruit unspecified	Fresh	—	Case report	Resolve DOI
Neurotoxicity	Neurologic	Fruit unspecified	Thermal treatment (heating for preservation)	—	Case report	Resolve DOI
Neurotoxicity	Brain	Fruit unspecified	—	—	Case report	Resolve DOI
Neurotoxicity	Neurologic	Unspecified	—	—	Case report	Resolve DOI
Neurotoxicity	Neurologic	—	—	—	Case report	Resolve DOI
Neurotoxicity	Neurologic	—	—	—	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Berdai, Mohamed Adnane., Labib, Smael., Chetouani, Khadija., Harandou, Mustapha. Atropa belladonna intoxication: a case report.. The Pan African medical journal, 2012, vol. 11, p. 72-72.
Heindl, S., Binder, C., Desel, H., Matthies, U., Lojewski, I., Bandelow, B., Kahl, GF., Chemnitius, JM. Confusion and excitability of initially undetermined cause in the course of poisoning with deadly nightshade in attempted suicide: symptoms, differential diagnosis, toxicology and physostigmine treatment of an anticholinergic syndrome. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2000, vol. 125, no. 45, p. 1361-1365. DOI
Southgate, HJ., Egerton, M., Dauncey, EA. Lessons to be learned: a case study approach Unseasonal severe poisoning of two adults by deadly nightshade (Atropa belladonna). JOURNAL OF THE ROYAL SOCIETY FOR THE PROMOTION OF HEALTH, 2000, vol. 120, no. 2, p. 127-130. DOI
Cikla, Ulas., Turkmen, Suha., Karaca, Yunus., Ayaz, Ahmet Faik., Turedi, Suleyman., Gunduz, Abdulkadir. An Atropa belladonna L. poisoning with acute subdural hematoma. HUMAN & EXPERIMENTAL TOXICOLOGY, 2011, vol. 30, no. 12, p. 1998-2001. DOI
Caksen, H., Odabas, D., Akbayram, S., Cesur, Y., Arslan, S., Uner, A., Oner, AF. Deadly nightshade (Atropa belladonna) intoxication: an analysis of 49 children. HUMAN & EXPERIMENTAL TOXICOLOGY, 2003, vol. 22, no. 12, p. 665-668. DOI
Ceha, L. J., Presperin, C., Young, E., Allswede, M., Erickson, T. Anticholinergic toxicity from nightshade berry poisoning responsive to physostigmine. Journal of Emergency Medicine, 1997, vol. 15, no. 1, p. 65-69. DOI
Detzel, A., Wink, M. Attraction, deterrence or intoxication of bees (Apis mellifera) by plant allelochemicals. Chemoecology, 1993, vol. 4, no. 1, p. 8-18. DOI
Paul, Rita., Datta, K. Animesh. An updated overview on Atropa belladonna L.. International research journal of pharmacy, 2011, vol. 2, no. 11, p. 11-17.
Godara, R., Katoch, M., Katoch, R., Yadav, Anish., Parveen, S., Vij, Bhavna., Khajuria, Varun., Singh, G., Singh, Nirbhay K. In vitro acaricidal activity of Atropa belladonna and its components, scopolamine and atropine, against Rhipicephalus (Boophilus) microplus.. TheScientificWorldJournal, 2014, vol. 2014, p. 713170-713170. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature