Botanical species · safety record

Berberis aquifolium

The EFSA Compendium of Botanicals holds 20 constituent measurements for Berberis aquifolium. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Berberis aquifolium Pursh

20Constituent measurements

0Safety records

7Cited sources

140Licensed products (Canada)

Also recorded as

Mahonia aquifolium (Pursh) Nutt.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 140 licensed products naming Berberis aquifolium as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh

Source material stated

Bark of root
Berberis aquifolium - Root and rhizome
Dried bark from branches and twigs and dried tips of twigs
Fresh root(s)
New material
Rhizome
Rhizome and root(s)
Root

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Alkaloids	Unspecified	Solvent extraction	0.64 Milligram/millilitre	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alkaloids	Unspecified	Solvent extraction	2.67 Milligram/millilitre	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aporphine alkaloids	Unspecified	—	—	Unspecified	Resolve DOI
Aromoline	Bark	Solvent extraction	0.005 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Berbamine	Bark	Solvent extraction	0.042 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Berberine	Bark	Solvent extraction	0.112 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Bisbenzylisoquinoline alkaloids	Bark	Solvent extraction	0.071 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Bisbenzylisoquinoline alkaloids	Bark	Solvent extraction	0.074 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Bisbenzylisoquinoline alkaloids	Bark	Solvent extraction	0.038 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Columbamine	Bark	Solvent extraction	0.03 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Jatrorrhizine	Unspecified	Solvent extraction	0.89 Milligram/millilitre	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Jatrorrhizine	Bark	Solvent extraction	0.146 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Magnoflorine	Unspecified	Solvent extraction	1.14 Milligram/millilitre	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Palmatine	Bark	Solvent extraction	0.088 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Berbamine	Unspecified	Solvent extraction	—	Unspecified	No resolvable identifier
Berberine	Bark	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Isocorydine	Unspecified	Solvent extraction	—	Unspecified	No resolvable identifier
Isoquinoline alkaloids	Aerial part of plants	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Jatrorrhizine	Bark	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Panov, P. P., Mollov, N. M., Panova, L. N. Alkaloids from plants of the Berberidaceae family. Doklady bolgarskoi akademii nauk, 1971, vol. 24, no. 5, p. 675-8.
SOTNIKOVA, R., KOSTALOVA, D., VAVERKOVA, S. EFFECT OF BISBENZYLISOQUINOLINE ALKALOIDS FROM MAHONIA-AQUIFOLIUM ON THE ISOLATED RAT AORTA . General pharmacology, 1994, vol. 25, no. 7, p. 1405-1410. DOI
Galle, K., Muller-Jakic, B., Proebstle, A., Jurcic, K., Bladt, S., Wagner, H. Analytical and pharmacological studies on Mahonia aquifolium.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 1994, vol. 1, no. 1, p. 59-62. DOI
MISIK, V., BEZAKOVA, L., MALEKOVA, L., KOSTALOVA, D. LIPOXYGENASE INHIBITION AND ANTIOXIDANT PROPERTIES OF PROTOBERBERINE AND APORPHINE ALKALOIDS ISOLATED FROM MAHONIA-AQUIFOLIUM . Planta medica, 1995, vol. 61, no. 4, p. 372-373. DOI
Rackova, Lucia., Oblozinsky, Marek., Kostalova, Daniela., Kettmann, Viktor., Bezakova, Lydia. Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids. . Journal of inflammation (london, england), 2007, vol. 4, p. 15-15. DOI
Cernakova, Marta., Kost'alova, Daniela., Kettmann, Viktor., Plodova, Miriam., Toth, Jaroslav., Drimal, Jan. Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium. Bmc complementary and alternative medicine [online computer file], 2002, vol. 2, p. No pp given.
Khusainova, Kh. Sh., Sadykov, Yu. D. Alkaloids from aerial parts of Mahonia aquifolium. Izvestiya akademii nauk tadzhikskoi ssr, otdelenie fiziko-matematicheskikh, khimicheskikh i geologicheskikh nauk, 1986, vol. (1), p. 41-4.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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