Botanical species · safety record

Broussonetia papyrifera

The EFSA Compendium of Botanicals holds 12 constituent measurements and 1 adverse-effect record for Broussonetia papyrifera. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Broussonetia papyrifera (L.) L'Hér. ex Vent.

12Constituent measurements

1Safety records

7Cited sources

33Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 33 licensed products naming Broussonetia papyrifera as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Fruit

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Unspecified	Solvent extraction	0.74 Percent	Phytochemical screening	Resolve DOI
Cardiac glycosides	Unspecified	Solvent extraction	—	Phytochemical screening	Resolve DOI
Dihydrosanguinarine	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Isoquinoline alkaloids	Fruit unspecified	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Lignans	Leaves	Solvent extraction	—	—	Resolve DOI
Moracin n	Flower	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Norchelerythrine	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Phlobotannins	Unspecified	Solvent extraction	—	Phytochemical screening	Resolve DOI
Saponins	Unspecified	Solvent extraction	1.53 Percent	Phytochemical screening	Resolve DOI
Scopoletin	Flower	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Tannins	Unspecified	Solvent extraction	10.56 Percent	Phytochemical screening	Resolve DOI
Epoxides	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Roots and other underground parts	Solvent extraction	—	In vitro	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Ran Xiao-Ku., Wang Xiao-Tong., Liu Pei-Pei., Chi Yu-Xin., Wang Bo-Jia., Dou De-Qiang., Kang Ting-Guo., Xiong Wei. Cytotoxic constituents from the leaves of Broussonetia papyrifera. Chinese journal of natural medicines, 2013, vol. 11, no. 3, p. 269-273. DOI
Khan, Amir Muhammad., Qureshi, Rizwana Aleem., Ullah, Faizan., Gilani, Syed Aneel., Nosheen, Asia., Sahreen, Sumaira., Laghari, Muhammad Khan., Laghari, Muhammad Yousif., Shafiq-Ur-Rehman., Hussain, Ishtiaq., Murad, Waheed. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings. JOURNAL OF MEDICINAL PLANTS RESEARCH, 2011, vol. 5, no. 25, p. 6017-6023. DOI
Luo, Liping., Shen, Liming., Sun, Fang., Dai, Yujie., Zheng, Heng., Ma, Zhongjun., Xu, Ying., Guo, Zengjun. Screening for aromatase ligands in the extract of Broussonetia papyrifera using high performance liquid chromatography and ESI-mass spectrometry. ANALYTICAL METHODS, 2012, vol. 4, no. 1, p. 230-235. DOI
Pang, Su-Qiu., Wang, Guo-Quan., Lin, Jun-Sheng., Diao, Yong., Xu, Rui-An. Cytotoxic activity of the alkaloids from Broussonetia papyrifera fruits. PHARMACEUTICAL BIOLOGY, 2014, vol. 52, no. 10, p. 1315-1319. DOI
Pang, Su-Qiu., Wang, Guo-Quan., Huang, Bao-Kang., Zhang, Qiao-Yan., Qin, Lu-Ping. Isoquinoline alkaloids from Broussonetia papyrifera fruits. CHEMISTRY OF NATURAL COMPOUNDS, 2007, vol. 43, no. 1, p. 100-102. DOI
Xu Xiao-Hua., Qian Shi-Hui., Bian Mei-Guang., Xie Ning., Yang Nian-Yun., Duan Jin-Ao. Chemical constituents from the leaves of Broussonetia papyrifera. Chinese Journal of Natural Medicines, 2007, vol. 5, no. 3, p. 190-192.
Ryu, Hyung Won., Lee, Byong Won., Curtis-Long, Marcus J., Jung, Sunin., Ryu, Young Bae., Lee, Woo Song., Park, Ki Hun. Polyphenols from Broussonetia papyrifera Displaying Potent alpha-Glucosidase Inhibition. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, vol. 58, no. 1, p. 202-208. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature