Botanical species · safety record

Buxus sempervirens

The EFSA Compendium of Botanicals holds 20 constituent measurements for Buxus sempervirens. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Buxus sempervirens L.

20Constituent measurements

0Safety records

11Cited sources

4Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 4 licensed products naming Buxus sempervirens as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Jeunes pousses
Leaf
Twig(s)
Young leaves and twigs
Young shoots

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Imperialine	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Wood	Solvent extraction	66 Percent	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Wood	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Wood	Solvent extraction	24 Percent	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Triterpene alkaloids	Unspecified	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Alkaloids	Unspecified	Solvent extraction	≥ 1 Percent	Chromatographic tests	No resolvable identifier
Alkaloids	Unspecified	Solvent extraction	≤ 35 Percent	Chromatographic tests	No resolvable identifier
Coumarins	Leaves	Solvent extraction	—	Unspecified	No resolvable identifier
Cyclobuxine	Leaves	Solvent extraction	—	Unspecified	No resolvable identifier
Hydroquinone	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Lutein epoxide	Bud	—	10 Millimole	Fluorimetry, Nephelometry and Polarimetry	No resolvable identifier
Saponins	Leaves	Solvent extraction	—	Unspecified	No resolvable identifier
Steroidal alkaloids	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Tannins	Leaves	Solvent extraction	—	Unspecified	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Liu, Hai-Feng., Ji, Min., Cai, Jin. Short and efficient approach towards buxozine-C, an alkaloid from Buxus sempervirens . Archiv der pharmazie, 2006, vol. 339, no. 12, p. 675-676. DOI
Eshonov, M. A., Turgunov, K. K., Tashkhodzhaev, B., Shakirov, R. Alkaloids of Buxus sempervirens, Crystal and Molecular Structure of Cyclobuxine-D and Imperialine . Chemistry of natural compounds, 2014, vol. 49, no. 6, p. 1179-1182. DOI
ATTAURRAHMAN., AHMED, D., ASIF, E., JAMAL, SA., CHOUDHARY, MI., SENER, B., TURKOZ, S. STEROIDAL ALKALOIDS FROM LEAVES OF BUXUS-SEMPERVIRENS. Phytochemistry, 1991, vol. 30, no. 4, p. 1295-1298.
Atta-ur-Rahman., Ata, A., Naz, S., Choudhary, MI., Sener, B., Turkoz, S. New steroidal alkaloids from the roots of Buxus sempervirens. Journal of natural products, 1999, vol. 62, no. 5, p. 665-669. DOI
AttaurRahman., Choudhary, MI., Naz, S., Ata, A., Sener, B., Turkoz, S. New steroidal alkaloids from the roots of Buxus sempervirens. Journal of natural products, 1997, vol. 60, no. 8, p. 770-774. DOI
Choudhary, M. Iqbal., Shahnaz, Salma., Parveen, Shehnaz., Khalid, Asaad., Mesaik, M. Ahmed., Ayatollahi, S. Abdul Majeed., Atta-ur-Rahman. New cholinesterase-inhibiting triterpenoid alkaloids from Buxus hyrcana. Chemistry & biodiversity, 2006, vol. 3, no. 9, p. 1039-1052. DOI
Ghodsi, M. R., Netien, G. Presence of arbutoside in the leaves of Buxus sempervirens. Bulletin des travaux de la societe de pharmacie de lyon, 1970, vol. 14, no. 4, p. 115-18.
Garcia-Plazaola, Jose I., Hormaetxe, Koldobika., Hernandez, Antonio., Olano, Jose M., Becerril, Jose M. The lutein epoxide cycle in vegetative buds of woody plants. Functional plant biology, 2004, vol. 31, no. 8, p. 815-823.
Brown, Jr., K.S., Kupchan, S.M. A convenient separation of alkaloid mixtures by partition chromatography, using an indicator in the stationary phase. Journal of chromatography a, 1962, vol. 9, no. C, p. 71-80.
Orazmuradov, G. M., Karryev, M. O. Chemical composition of Buxus sempervirens leaves. Izvestiya akademii nauk turkmenskoi ssr, seriya biologicheskikh nauk, 1974, vol. (6), p. 71-3.
Leuthardt, Florine L. G., Glauser, Gaetan., Baur, Bruno. Composition of alkaloids in different box tree varieties and their uptake by the box tree moth Cydalima perspectalis . Chemoecology, 2013, vol. 23, no. 4, p. 203-212. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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