Botanical species · safety record

Calendula officinalis

The EFSA Compendium of Botanicals holds 12 constituent measurements and 3 genotoxicity assays for Calendula officinalis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Calendula officinalis L.

12Constituent measurements

3Safety records

9Cited sources

570Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 570 licensed products naming Calendula officinalis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid

Source material stated

Aerial parts
Calendula officinalis
Calendula officinalis - flower
Calendula officinalis-Flowering tops
Dried flower(s)
Flower
Flower buds
Flower extract

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Unspecified	Solvent extraction	13.4 Microgram/millilitre	HPLC-DAD	Resolve DOI
Epigallocatechin	Aerial part of plants	Solvent extraction	230.01 Microgram/gram	MALDI-TOFMS	Resolve DOI
Epigallocatechin gallate	Unspecified	Solvent extraction	2.6 Nanogram/millilitre	HPLC-DAD	Resolve DOI
Epigallocatechin gallate	Aerial part of plants	Solvent extraction	≤ 370.43 Microgram/gram	MALDI-TOFMS	Resolve DOI
Epigallocatechin gallate	Aerial part of plants	Solvent extraction	≥ 132.7 Microgram/gram	MALDI-TOFMS	Resolve DOI
Gallic acid	Unspecified	Solvent extraction	0.8 Nanogram/millilitre	HPLC-DAD	Resolve DOI
Gallocatechin	Unspecified	Solvent extraction	0.9 Nanogram/millilitre	HPLC-DAD	Resolve DOI
P-coumaric acid	Unspecified	Solvent extraction	0.5 Nanogram/millilitre	HPLC-DAD	Resolve DOI
Saponins	Unspecified	Solvent extraction	17.6 Microgram/millilitre	HPLC-DAD	Resolve DOI
Saponins	Flower	Solvent extraction	8.8 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Coumarins	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Triterpene saponins	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	—	DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro	Rat (as animal)	No data	Resolve DOI
Positive	chromosome aberration	in vitro gene mutation assay in fungi	Other	No data	Resolve DOI
Positive	—	unscheduled DNA synthesis	Rat (as animal)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Hernandez-Saavedra, Diego., Perez-Ramirez, Iza F., Ramos-Gomez, Minerva., Mendoza-Diaz, Sandra., Loarca-Pina, Guadalupe., Reynoso-Camacho, Rosalia. Phytochemical characterization and effect of Calendula officinalis, Hypericum perforatum, and Salvia officinalis infusions on obesity-associated cardiovascular risk . Medicinal chemistry research, 2016, vol. 25, no. 1, p. 163-172. DOI
Sabir, Syed Mubashar., Khan, Muhammad Fareed., Rocha, Joao Batista Texeira., Boligon, Aline Augusti., Athayde, Margareth Linde. Phenolic Profile, Antioxidant Activities and Genotoxic Evaluations of Calendula officinalis . Journal of food biochemistry, 2015, vol. 39, no. 3, p. 316-324. DOI
Balsevich, J. John., Bishop, Greg G., Deibert, Leah K. Use of Digitoxin and Digoxin as Internal Standards in HPLC Analysis of Triterpene Saponin-Containing Extracts . Phytochemical analysis, 2009, vol. 20, no. 1, p. 38-49. DOI
Ramos, A., Edreira, A., Vizoso, A., Betancourt, J., Lopez, M., Decalo, M. Genotoxicity of an extract of Caldendula officinalis L.. Journal of ethnopharmacology, 1998, vol. 61, no. 1, p. 49-55. DOI
Perez-Carreon, JI., Cruz-Jimenez, G., Licea-Vega, JA., Popoca, EA., Fazenda, SF., Villa-Trevino, S. Genotoxic and anti-genotoxic properties of Calendula officinalis extracts in rat liver cell cultures treated with diethylnitrosamine . Toxicology in vitro, 2002, vol. 16, no. 3, p. 253-258. DOI
Mohamed, Mona., Sterner, Olov., Bergquistt, Karl-Erik. Phytochemical and cytotoxic studies on Calendula officinalis. Life science journal, 2015, vol. 12, no. 1), 194-20, p. 8 pp.
Matei, Alina Oana., Gatea, Florentina., Teodor, Eugenia Dumitra., Radu, Gabriel Lucian. Tannins analysis from different medicinal plants extracts using MALDI-TOF and MEKC . Chemical papers, 2016, vol. 70, no. 4, p. 515-522. DOI
Derkach, A. I., Komissarenko, N. F., Chernobai, V. T. Coumarins from inflorescences of Calendula officinalis and Helichrysum arenarium. Khimiya prirodnykh soedinenii, 1986, vol. (6), p. 777.
[Anonymous]. Final report on the safety assessment of Calendula officinalis extract and Calendula officinalis. . International journal of toxicology, 2001, vol. 20 Suppl 2, p. 13-20.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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