Botanical species · safety record

Calotropis gigantea

The EFSA Compendium of Botanicals holds 13 constituent measurements and 1 adverse-effect record for Calotropis gigantea. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Calotropis gigantea (L.) W.T.Ait.

13Constituent measurements

1Safety records

7Cited sources

11Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 11 licensed products naming Calotropis gigantea as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Calcium oxalate	Aerial part of plants	Solvent extraction	1 Percent	Unspecified	Resolve DOI
Cardenolides	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Cardiac glycosides	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Cardiac glycosides	Aerial part of plants	Solvent extraction	—	Unspecified	Resolve DOI
Coumarins	Stem / stalk	Solvent extraction	—	Phytochemical screening	Resolve DOI
Lignans	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Saponins	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Saponins	Stem / stalk	Solvent extraction	—	Phytochemical screening	Resolve DOI
Tannins	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Calotropin	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Cardenolides	Leaves	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Frugosides	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Reproductive	Uterus	Roots and other underground parts	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Srivastava, Shobha Rani., Keshri, Govind., Bhargavan, Biju., Singh, Chandan., Singh, Man Mohan. Pregnancy interceptive activity of the roots of Calotropis gigantea Linn. in rats . Contraception, 2007, vol. 75, no. 4, p. 318-322. DOI
Lhinhatrakool, Thitima., Sutthivaiyakit, Somyote. 19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea . Journal of natural products, 2006, vol. 69, no. 8, p. 1249-1251. DOI
Kiuchi, F., Fukao, Y., Maruyama, T., Obata, T., Tanaka, M., Sasaki, T., Mikage, M., Haque, ME., Tsuda, Y. Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.) . Chemical & pharmaceutical bulletin, 1998, vol. 46, no. 3, p. 528-530.
Ghule, S.D., Vidyasagar, G., Bhandari, A., Sharma, P., Gunjal, A.P. CNS activity of leaves extract of Calotropis gigantea. Asian pacific journal of tropical disease, 2014, vol. 4, no. S2, p. S902-S905. DOI
Hasballah, K., Murniana., Erya., Ardian. Cytotoxic bioactive compounds from calotropis gigantea stem bark. International journal of pharmacy and pharmaceutical sciences, 2016, vol. 8, no. 9, p. 111-115. DOI
Seeka, Chonticha., Sutthivaiyakit, Somyote. Cytotoxic Cardenolides from the Leaves of Calotropis gigantea. Chemical & pharmaceutical bulletin, 2010, vol. 58, no. 5, p. 725-728.
Murti, P.B.R., Seshadri, T.R. Chemical composition of Calotropis gigantea - Part I. Wax and resin components of the latex. Proceedings of the indian academy of sciences - section a, 1943, vol. 18, no. 3, p. 145-159. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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