Botanical species · safety record

Calotropis procera

The EFSA Compendium of Botanicals holds 13 constituent measurements, 4 adverse-effect records and 1 genotoxicity assay for Calotropis procera. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Calotropis procera (Aiton) Dryand

13Constituent measurements

5Safety records

8Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Calotropin	Unspecified	—	—	Unspecified	Resolve DOI
Calotropins	Leaves	Latex	—	Unspecified	Resolve DOI
Cardenolide glycosides	Unspecified	—	—	Unspecified	Resolve DOI
Cardiac glycosides	Unspecified	—	—	Unspecified	Resolve DOI
Uscharin	Aerial part of plants	Latex	—	Unspecified	Resolve DOI
Alkaloids	Flower	Solvent extraction	—	Unspecified	No resolvable identifier
Calotropin	Aerial part of plants	Latex	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Cardenolides	Aerial part of plants	Latex	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Cyclic pentapeptides	Aerial part of plants	Latex	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Saponins	Aerial part of plants	Latex	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Tannins	Aerial part of plants	Latex	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Uscharidin	Aerial part of plants	Latex	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Uscharin	Unspecified	Latex	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Immunotoxicity	—	Aerial part of plants	Latex (as part-nature)	House mouse (as animal)	Short-term toxicity	Resolve DOI
None	Digestive	Aerial part of plants	Latex (as part-nature)	House mouse (as animal)	Acute toxicity	Resolve DOI
Not stated	Stomach	Leaves	Latex (as part-nature)	Human (as organism)	Case report	Resolve DOI
Not stated	Stomach	Leaves	Latex (as part-nature)	Human (as organism)	Case report	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	in vitro mammalian chromosome aberration test	Mammals (as animal)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Juca, Thiago Lustosa., Ramos, Marcio Viana., Moreno, Frederico Bruno Mendes Batista., Viana de Matos, Mayara Patricia., Marinho-Filho, Jose Delano Barreto., Moreira, Renato Azevedo., Monteiro-Moreira, Ana Cristina de Oliveira. Insights on the phytochemical profile (cyclopeptides) and biological activities of Calotropis procera latex organic fractions. Scientific world journal, 2013, vol. 615454/1-615454/9, p. 10 pp.
Abdel-Samad, M.F., Hassanane, M.M. Evaluation of genotoxic and cytotoxic potentials of Uscharin in male albino mice. World applied sciences journal, 2014, vol. 31, no. 6, p. 1020-1024. DOI
Kushwaha, Veena B., Singh, Aradhana. Effect of Uscharin on the Reproduction of the Snail Lymnaea acuminata.. World journal of zoology, 2010, vol. 5, no. 1, p. 15-19.
Crout, D.H.G., Hassall, C.H., Jones, T.L. Cardenolides. Part VI.1 Uscharidin, calotropin, and calotoxin. Journal of the chemical society (resumed), 1964, p. 2175-2187.
Aggarwal, Rama., Kaur, Kiranjeet., Suri, Mansi., Bagai, Upma. Anthelmintic potential of Calotropis procera, Azadirachta indica and Punica granatum against Gastrothylax indicus. . Journal of parasitic diseases : official organ of the indian society for parasitology, 2016, vol. 40, no. 4, p. 1230-1238.
Newman, R.A., Yang, P., Pawlus, A.D., Block, K.I. Cardiac glycosides as novel cancer therapeutic agents. Molecular interventions, 2008, vol. 8, no. 1, p. 36-49. DOI
Mishra, A.K., George, A., Devakiruba, N.S., Sathyendra, S. A rare case of calotropis poisoning. Indian journal of forensic medicine and toxicology, 2015, vol. 9, no. 2, p. 62-64. DOI
Bezerra, Camila F., Mota, Erika F., Silva, Ana Claudia M., Tome, Adriana R., Silva, Maria Z. R., de Brito, Daniel., Porfirio, Camila T. M. N., Oliveira, Ariclecio C., Lima-Filho, Jose V., Ramos, Marcio V. Latex proteins from Calotropis procera: Toxicity and immunological tolerance revisited . Chemico-biological interactions, 2017, vol. 274, p. 138-149. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature