Botanical species · safety record

Carica papaya

The EFSA Compendium of Botanicals holds 7 constituent measurements, 10 adverse-effect records and 1 genotoxicity assay for Carica papaya. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Carica papaya L.

7Constituent measurements

11Safety records

7Cited sources

379Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 379 licensed products naming Carica papaya as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Fresh

Source material stated

Carica papaya
Carica papaya - Whole plant
Carica papaya - fruit
Carica papaya - leaf
Carica papaya, fruit
Edible fruit part
Fruit
Fruit extract

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	Unspecified	Resolve DOI
Alkaloids	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Saponins	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Tannins	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Alkaloids	Fruit unspecified	Solvent extraction	5.4 Percent	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Coumarins	Fruit unspecified	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Emodin	Fruit unspecified	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Leaves	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI
Reproductive	Testes	Seed	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Uterus	Seed	—	Human (as organism)	Not reported	Resolve DOI
Reproductive	Testes	Seed	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Hepatotoxicity	Liver	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Hepatotoxicity	Liver	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Reproductive	Uterus	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier
Reproductive	Uterus	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier
Reproductive	Testes	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier
Reproductive	Testes	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Human (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Ansah, C., Appiah, J.A., Mensah, K.B., Mante, P.K. Aqueous leaf extract of Carica papaya (Caricaceae) Linn. Causes liver injury and reduced fertility in rats. International journal of pharmacy and pharmaceutical sciences, 2016, vol. 8, no. 2, p. 261-265.
Luiz, Tatiane Cordeiro., Simoes da Cunha, Ana Paula., Aguiar, Danilo Henrique., Sugui, Marina Mariko., Bicudo, Rogerio de Campos., Sinhorin, Adilson Paulo., Gindri Sinhorin, Valeria Dornelles. Antioxidant potential of Carica papaya Linn (Caricaceae) leaf extract in mice with cyclophosphamide induced oxidative stress. Scientia medica, 2020, vol. 30, no. 1. DOI
Bhatia, Harpreet., Manhas, R. K., Kumar, Kewal., Magotra, Rani. Traditional knowledge on poisonous plants of Udhampur district of Jammu and Kashmir, India . Journal of ethnopharmacology, 2014, vol. 152, no. 1, p. 207-216. DOI
LOHIYA, NK., GOYAL, RB., JAYAPRAKASH, D., ANSARI, AS., SHARMA, S. ANTIFERTILITY EFFECTS OF AQUEOUS EXTRACT OF CARICA-PAPAYA SEEDS IN MALE-RATS. Planta medica, 1994, vol. 60, no. 5, p. 400-404. DOI
Wan-Ibrahim, W. I., Sidik, K., Kuppusamy, U. R. A high antioxidant level in edible plants is associated with genotoxic properties. Food chemistry, 2010, vol. 122, no. 4, p. 1139-1144. DOI
Gupta, A., Sharma, S., Verma, H.K., Tyagi, D.S., Mishra, P.K., Patra, P.K. Phytochemical characterization of twelve medicinal plants used for sickle cell disease management in chhattisgarh. International journal of pharma and bio sciences, 2015, vol. 6, no. 2, p. B1062-B1070.
Handayani, L., Faridah, D.N., Kusumaningrum, H.D. Staphylococcal enterotoxin a gene-carrying Staphylococcus aureus isolated from foods and its control by crude alkaloid from papaya leaves. Journal of food protection, 2014, vol. 77, no. 11, p. 1992-1997. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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