Botanical species · safety record

Cascabela thevetia

The EFSA Compendium of Botanicals holds 4 constituent measurements, 18 adverse-effect records and 1 genotoxicity assay for Cascabela thevetia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Cascabela thevetia (L.) Lippold

4Constituent measurements

19Safety records

11Cited sources

0Licensed products (Canada)

Also recorded as

Thevetia neriifolia Juss. ex A.DC.
Thevetia peruviana (Pers.) K.Schum.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	Traditional analytical techniques (wet chemical tests)	Resolve DOI
Cardiac glycosides	Seed	—	—	Unspecified	Resolve DOI
Thevetine	Seed	Solvent extraction	64 Percent	HPLC with standard detection methods	No resolvable identifier
Thevetine	Seed	Solvent extraction	37 Percent	HPLC with standard detection methods	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Aerial part of plants	—	Human (as organism)	Case report	Resolve DOI
Hepatotoxicity	Liver	Seed	—	Human (as organism)	Case report	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Unspecified	—	Human (as organism)	Not reported	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	Seed	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Neurotoxicity	Neurologic	Seed	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Pulmonary and cardiac	Heart	Seed	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Pulmonary and cardiac	Heart	Seed	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Pulmonary and cardiac	Heart	Seed	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI
Pulmonary and cardiac	Neurologic: central nervous system	Seed	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Seed	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Fruit unspecified	Fresh	Human (as organism)	Case report	Resolve DOI
Reproductive	Uterus	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Uterus	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Vagina	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Vagina	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Systemic	Neurologic: central nervous system	Aerial part of plants	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Seed	—	Human (as organism)	Case report	No resolvable identifier
Pulmonary and cardiac	Heart	Aerial part of plants	—	Cattle (as animal)	Case report	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	chromosome aberration assay	Other	—	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Murugan, K. Genotoxic assessment of seed extracts of Thevetia peruviana pers. and Cerbera odollam gaertn. using chromosome aberration study . Journal of phytological research, 2005, vol. 18, no. 2, p. 121-128.
Marroquin-Segura, Ruben., Calvillo-Esparza, Ricardo., Alfredo Mora-Guevara, Jose Luis., Horacio Tovalin-Ahumada, Jose., Aguilar-Contreras, Abigail., Jesus Hernandez-Abad, Vicente. Increased acetylcholine esterase activity produced by the administration of an aqueous extract of the seed kernel of Thevetia peruviana and its role on acute and subchronic intoxication in mice . Pharmacognosy magazine, 2014, vol. 10, no. 37, p. S171-S175. DOI
Oji, O., Okafor, QE. Toxicological studies on stem bark, leaf and seed kernel of yellow oleander (Thevetia peruviana) . Phytotherapy research, 2000, vol. 14, no. 2, p. 133-135. DOI
SAMAL, KK., SAHU, HK., GOPALAKRISHNAKONE, P. CLINICOPATHOLOGICAL STUDY OF THEVETIA-PERUVIANA (YELLOW OLEANDER) POISONING . Journal of wilderness medicine, 1992, vol. 3, no. 4, p. 382-386. DOI
Samanta, Jhuma., Bhattacharya, Snehendu., Rana, Avtar C. Antifertility activity of Thevetia peruviana (Pers.) K. Schum leaf in female Sprague-Dawley rat . Indian journal of pharmacology, 2016, vol. 48, no. 6, p. 669-674. DOI
Tokarnia, Carlos Hubinger., Armien, Anibal Guillemo., Peixoto, Paul Vargas., Barbosa, Jose Diomedes., Brito, Marilene De Farias., Dobereiner, Jurgen. Experiments on the toxicity of some ornamental plants in cattle. Pesquisa veterinaria brasileira, 1996, vol. 16, no. 1, p. 5-20.
Gopalakrishnan, Shiv Kumar., Kandasamy, Sangeetha., Isaac, Bensy., Jayasankar, Chandini., Chandru. Oleander toxicity - the clinical spectrum and mortality predictors: an observational study . Internet journal of medical update, 2017, vol. 12, no. 1, p. 4-8. DOI
Escobar Rom�n, Raylen., Leiva Acebey, Leonardo., Morales Espinosa, Juan. Intoxicaci�n por Cascabela thevetia (L)Lippold (covadonga). Presentaci�n de un caso . Medisur, 2012, vol. 10, no. 1, p. 55-57.
Luyckx, V.A. Nephrotoxicity of Alternative Medicine Practice. Advances in chronic kidney disease, 2012, vol. 19, no. 3, p. 129-141. DOI
Kohls, Sarah., Scholz-Boetteher, Barbara M., Teske, Joerg., Rillkoetter, Juergen. Isolation and quantification of six cardiac glycosides from the seeds of Thevetia peruviana provide a basis for toxological survey . Indian journal of chemistry section b-organic chemistry including medicinal chemistry, 2015, vol. 54, no. 12, p. 1502-1510.
Lucas, G. N. Plant poisoning: A hospital-based study in Sri Lanka. Indian journal of pediatrics, 1997, vol. 64, no. 4, p. 495-502. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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