Botanical species · safety record

Caulophyllum thalictroides

The EFSA Compendium of Botanicals holds 33 constituent measurements and 1 adverse-effect record for Caulophyllum thalictroides. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Caulophyllum thalictroides (L.) Michx.

33Constituent measurements

1Safety records

7Cited sources

88Licensed products (Canada)

Also recorded as

Leontice thalictroides L.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 88 licensed products naming Caulophyllum thalictroides as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Aerial parts
Fresh underground parts harvested in late summer
Rhizome
Rhizome and root(s)
Rhizome(s)
Root
Tincture of the rhizome
Tincture of the root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
(-)-sparteine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Alkaloids	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Anagyrine	Roots and other underground parts	Solvent extraction	≥ 0.18 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Anagyrine	Roots and other underground parts	Solvent extraction	≤ 0.19 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Baptifoline	Roots and other underground parts	Solvent extraction	≤ 1600 Milligram/kilogram	GC-MS	Resolve DOI
Baptifoline	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Baptifoline	Roots and other underground parts	Solvent extraction	≥ 0.71 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Baptifoline	Roots and other underground parts	Solvent extraction	≥ 9 Milligram/kilogram	GC-MS	Resolve DOI
Baptifoline	Roots and other underground parts	Solvent extraction	≤ 0.75 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Isolupanine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Lupanine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Magnoflorine	Roots and other underground parts	Solvent extraction	≥ 11 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Magnoflorine	Roots and other underground parts	Solvent extraction	≤ 11.08 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Magnoflorine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Magnoflorine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
N-methylcytisine	Roots and other underground parts	Solvent extraction	≥ 0.9 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
N-methylcytisine	Roots and other underground parts	Solvent extraction	≤ 0.91 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
N-methylcytisine	Roots and other underground parts	Solvent extraction	≥ 5 Milligram/kilogram	GC-MS	Resolve DOI
N-methylcytisine	Live plants	Drying (dehydration)	≤ 0.04 Percent	—	Resolve DOI
N-methylcytisine	Roots and other underground parts	Solvent extraction	≤ 850 Milligram/kilogram	GC-MS	Resolve DOI
N-methylcytisine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
N-methylcytisine	Live plants	Drying (dehydration)	≥ 0.003 Percent	—	Resolve DOI
Quinolizidine alkaloids	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Quinolizidine alkaloids	Roots and other underground parts	Solvent extraction	≤ 2840 Milligram/kilogram	GC-MS	Resolve DOI
Quinolizidine alkaloids	Roots and other underground parts	Solvent extraction	≥ 16 Milligram/kilogram	GC-MS	Resolve DOI
Saponin glycosides	Live plants	Drying (dehydration)	—	—	Resolve DOI
Taspine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Thermopsine	Roots and other underground parts	Solvent extraction	≤ 390 Milligram/kilogram	GC-MS	Resolve DOI
Thermopsine	Roots and other underground parts	Solvent extraction	≥ 2 Milligram/kilogram	GC-MS	Resolve DOI
Thermopsine	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Triterpene saponins	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Triterpene saponins	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Digestive	Unspecified	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Betz, JM., Andrzejewski, D., Troy, A., Casey, RE., Obermeyer, WR., Page, SW., Woldemariam, TZ. Gas chromatographic determination of toxic quinolizidine alkaloids in blue cohosh Caulophyllum thalictroides (L,) Michx . Phytochemical analysis, 1998, vol. 9, no. 5, p. 232-236. DOI
Kennelly, EJ., Flynn, TJ., Mazzola, EP., Roach, JA., McCloud, TG., Danford, DE., Betz, JM. Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture . Journal of natural products, 1999, vol. 62, no. 10, p. 1385-1389. DOI
Woldemariam, TZ., Betz, JM., Houghton, PJ. Analysis of aporphine and quinolizidine alkaloids from Caulophyllum thalictroides by densitometry and HPLC . Journal of pharmaceutical and biomedical analysis, 1997, vol. 15, no. 6, p. 839-843. DOI
Rao, RB., Hoffman, RS. Nicotinic toxicity from tincture of blue cohosh (Caulophyllum thalictroides) used as an abortifacient . Veterinary and human toxicology, 2002, vol. 44, no. 4, p. 221-222.
Ganzera, M., Dharmaratne, HRW., Nanayakkara, NPD., Khan, IA. Determination of saponins and alkaloids in Caulophyllum thalictroides (blue cohosh) by high-performance liquid chromatography and evaporative light scattering detection . Phytochemical analysis, 2003, vol. 14, no. 1, p. 1-7. DOI
Ali, Zulfiqar., Khan, Ikhlas A. Alkaloids and saponins from blue cohosh. Phytochemistry, 2008, vol. 69, no. 4, p. 1037-1042. DOI
Schep, Leo J., Slaughter, Robin J., Beasley, D. Michael G. Nicotinic plant poisoning. Clinical toxicology, 2009, vol. 47, no. 8, p. 771-781. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature