Botanical species · safety record

Centella asiatica

The EFSA Compendium of Botanicals holds 5 constituent measurements and 12 adverse-effect records for Centella asiatica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Centella asiatica ( L.) Urb.

5Constituent measurements

12Safety records

5Cited sources

315Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 315 licensed products naming Centella asiatica as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh

Source material stated

Aerial parts
Branch(es)
Centella asiatica
Centella asiatica - Leaf
Dried aerial part(s)
Dried herb
Dried whole plant
Entire dried plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Unspecified	Solvent extraction	—	Unspecified	Resolve DOI
Proanthocyanidins (condensed tannins)	Leaves	Solvent extraction	97.2 Milligram/gram	Unspecified	Resolve DOI
Saponins	Unspecified	Solvent extraction	—	Unspecified	Resolve DOI
Alkaloids	Leaves	Solvent extraction	—	Unspecified	No resolvable identifier
Polyacetylene derivatives	Live plants	Solvent extraction	—	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive: pancreas	Leaves	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive	Leaves	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive	Leaves	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive: pancreas	Leaves	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive	Leaves	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive	Leaves	Solvent extraction	—	In vitro	Resolve DOI
Hepatotoxicity	Liver	Unspecified	—	Human (as organism)	Case report	Resolve DOI
Reproductive	Testes	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Testes	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Testes	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Testes	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Hepatotoxicity	Liver	—	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Heidari, Mahnaz., Heidari-Vala, Hamed., Sadeghi, Mohammad Reza., Akhondi, Mohammad Mehdi. The inductive effects of Centella asiatica on rat spermatogenic cell apoptosis in vivo . Journal of natural medicines, 2012, vol. 66, no. 2, p. 271-278. DOI
Adisakwattana, Sirichai., Jiphimai, Pariwat., Prutanopajai, Pornsawan., Chanathong, Benjanut., Sapwarobol, Suwimol., Ariyapitipan, Tipayanate. Evaluation of alpha-glucosidase, alpha-amylase and protein glycation inhibitory activities of edible plants. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2010, vol. 61, no. 3, p. 295-305. DOI
Chitturi, Shivakumar., Farrell, Geoffrey C. Hepatotoxic slimming aids and other herbal hepatotoxins. Journal of gastroenterology and hepatology, 2008, vol. 23, no. 3, p. 366-373. DOI
Jorge, OA., Jorge, AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Revista espanola de enfermedades digestivas, 2005, vol. 97, no. 2, p. 115-120.
Chong, N.J., Aziz, Z. A systematic review on the chemical constituents of Centella asiatica. Research journal of pharmaceutical, biological and chemical sciences, 2011, vol. 2, no. 3, p. 445-459.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature