Botanical species · safety record

Cicuta maculata

The EFSA Compendium of Botanicals holds 11 constituent measurements and 4 adverse-effect records for Cicuta maculata. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Cicuta maculata L.

11Constituent measurements

4Safety records

5Cited sources

4Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 4 licensed products naming Cicuta maculata as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Bergapten	Seed	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Bergapten	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Cicutol	Roots and other underground parts used as staple food	Solvent extraction	—	GC-MS	Resolve DOI
Cicutol	Seed	Solvent extraction	—	GC-MS	Resolve DOI
Cicutoxin	Seed	Solvent extraction	—	GC-MS	Resolve DOI
Cicutoxin	Roots and other underground parts used as staple food	Solvent extraction	—	GC-MS	Resolve DOI
Furanocoumarins	Seed	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Isoimperatorin	Seed	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Methoxsalen	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Methoxsalen	Seed	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Coniine	Roots and other underground parts	Solvent extraction	0.13 Percent	—	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic: central nervous system	Seed	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	Roots and other underground parts used as staple food	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Neurotoxicity	Digestive	Roots and other underground parts	—	Human (as organism)	Case report	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	Roots and other underground parts used as staple food	Fresh	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

BERENBAUM, M. PATTERNS OF FURANOCOUMARIN DISTRIBUTION AND INSECT HERBIVORY IN THE UMBELLIFERAE - PLANT CHEMISTRY AND COMMUNITY STRUCTURE . Ecology, 1981, vol. 62, no. 5, p. 1254-1266. DOI
Panter, Kip E., Gardner, Dale R., Stegelmeier, Bryan L., Welch, Kevin D., Holstege, Dirk. Water hemlock poisoning in cattle: Ingestion of immature Cicuta maculata seed as the probable cause . Toxicon, 2011, vol. 57, no. 1, p. 157-161. DOI
Centers For Disease Control (Usa). Water hemlock poisoning: Maine, 1992. Morbidity and mortality weekly report, 1994, vol. 43, no. 13, p. 229-231.
Marion, Leo. The isolation of cicutin from Cicuta maculata L. Canadian journal of research, section b: chemical sciences, 1942, vol. 20;B, p. 157-60.
Schep, Leo J., Slaughter, Robin J., Becket, Gordon., Beasley, D. Michael G. Poisoning due to water hemlock. Clinical toxicology, 2009, vol. 47, no. 4, p. 270-278. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature