Botanical species · safety record

Cicuta virosa

The EFSA Compendium of Botanicals holds 14 constituent measurements and 2 adverse-effect records for Cicuta virosa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Cicuta virosa L.

14Constituent measurements

2Safety records

8Cited sources

23Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 23 licensed products naming Cicuta virosa as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Fresh underground parts
Root
Tincture of the root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Apterin	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Cicutol	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Cicutoxin	Roots and other underground parts	Solvent extraction	0.044 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Cicutoxin	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Coumarins	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Falcarindiol	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Furanocoumarins	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Polyacetylene derivatives	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Polyacetylene derivatives	Roots and other underground parts	Solvent extraction	0.013 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Virol a	Roots and other underground parts	Solvent extraction	0.0015 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Virol c	Roots and other underground parts	Solvent extraction	0.0012 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Cicutol	Roots and other underground parts	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Cicutoxin	Roots and other underground parts	—	1.65 Gram/kilogram	Unspecified	No resolvable identifier
Myrcene	Fruit unspecified	Essential oil	2.7 Percent	Gaschromatography (GC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic: central nervous system	Roots and other underground parts	—	Human (as organism)	Case report	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	Roots and other underground parts	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kohanawa, Makoto., Tsuji, Hiroshi. The antagonism of hypnotics against cicutoxin, a poisonous principle isolated from Cicuta virosa. Nippon yakurigaku zasshi, 1957, vol. 53(Breviaria 1-2(in English)), p. 41-8.
Wang, Shu-Qi., Li, Xia., Wang, Xiao-Ning., Wei, Na-Na., Lou, Hong-Xiang. Coumarins from Cicuta virosa and their modulating effects on multidrug-resistant (MDR) tumors . Phytochemistry letters, 2011, vol. 4, no. 2, p. 97-100. DOI
Ohta, T., Uwai, K., Kikuchi, R., Nozoe, S., Oshima, Y., Sasaki, K., Yoshizaki, F. Absolute stereochemistry of cicutoxin and related toxic polyacetylenic alcohols from Cicuta virosa . Tetrahedron, 1999, vol. 55, no. 41, p. 12087-12098. DOI
WITTSTOCK, U., HADACEK, F., WURZ, G., TEUSCHER, E., GREGER, H. POLYACETYLENES FROM WATER HEMLOCK, CICUTA-VIROSA. Planta medica, 1995, vol. 61, no. 5, p. 439-445. DOI
Anet, E.F.L.J., Lythgoe, B., Silk, M.H., Trippett, S. Oenanthotoxin and cicutoxin. Isolation and structures. Journal of the chemical society (resumed), 1953, p. 309-322.
Schep, Leo J., Slaughter, Robin J., Becket, Gordon., Beasley, D. Michael G. Poisoning due to water hemlock. Clinical toxicology, 2009, vol. 47, no. 4, p. 270-278. DOI
Orlov, N. I. Poisoning by Cicuta roots. Gigiena i sanitariya, 1948, vol. 13(No. 9), p. 35-6.
Kozhin, S. A., Kovaleva, G. A. The essential oil of water hemlock. Sintetich. produkty iz kanifoli i skipidara, akad. nauk belorussk. ssr, tsentr. nauchn.-issled. i proektn. inst. lesokhim. prom., tr. vses. nauchn.-tekhn. soveshch., gorki, 1964, vol. 1963, p. 310-19.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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