Botanical species · safety record

Cinchona calisaya

The EFSA Compendium of Botanicals holds 16 constituent measurements for Cinchona calisaya. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Cinchona calisaya Wedd.

16Constituent measurements

0Safety records

6Cited sources

1Licensed products (Canada)

Also recorded as

Cinchona ledgeriana (Howard) Bern.Moens ex Trimen
Cinchona peruviana Howard

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1 licensed products naming Cinchona calisaya as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Bark

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Roots and other underground parts	Solvent extraction	12.5 Millimole/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Quinoline alkaloids	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Alkaloids	Bark	Solvent extraction	≥ 2.25 Percent	Unspecified	No resolvable identifier
Alkaloids	Bark	Solvent extraction	9.1 Percent	Unspecified	No resolvable identifier
Alkaloids	Bark	Solvent extraction	≤ 4.1 Percent	Unspecified	No resolvable identifier
Alkaloids	Bark	Drying (dehydration)	4.5 Percent	Unspecified	No resolvable identifier
Cinchonidine	Bark	Solvent extraction	0.105 Percent	Unspecified	No resolvable identifier
Cinchonidine	Bark	Drying (dehydration)	0.86 Percent	Unspecified	No resolvable identifier
Cinchonine	Bark	Solvent extraction	0.085 Percent	Unspecified	No resolvable identifier
Cinchonine	Bark	Drying (dehydration)	0.26 Percent	Unspecified	No resolvable identifier
Quinidine	Bark	Solvent extraction	0.08 Percent	Unspecified	No resolvable identifier
Quinine	Seed	Solvent extraction	0.38 Percent	Unspecified	No resolvable identifier
Quinine	Bark	Solvent extraction	≤ 2.75 Percent	Unspecified	No resolvable identifier
Quinine	Bark	Drying (dehydration)	3.38 Percent	Unspecified	No resolvable identifier
Quinine	Bark	Solvent extraction	≥ 0.961 Percent	Unspecified	No resolvable identifier
Quinine	Bark	Solvent extraction	7.92 Percent	Unspecified	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

van Lerrsum, P. The occurrence of quinine in the seeds of Cinchona ledgeriana Moens. Pharmaceutisch weekblad, 1914, vol. 50, p. 1464-7.
Wasicky, R., Unti, O., Barbieri, E. Quinine and alkaloids in Brazil. Anais faculdade farm. odontol. univ. sao paulo, 1943, vol. 1942-1943, 3, p. 137-83.
Cheng, Gui-Guang., Zhang, Yu., Cai, Xiang-Hai., Bao, Mei-Fen., Gu, Ji., Li, Yan., Liu, Ning., Liu, Ya-Ping., Luo, Xiao-Dong. Cincholenines A and B, two unprecedented quinoline alkaloids from Cinchona ledgeriana . Tetrahedron letters, 2013, vol. 54, no. 34, p. 4547-4550. DOI
Peterson, Lyall E. Cinchona-the quinine tree. J. forestry, 1947, vol. 45, p. 500-2.
Hodge, W. H. Wartime Cinchona procurement in Latin America. Economic botany, 1948, vol. 2, p. 229-57.
AERTS, RJ., SNOEIJER, W., VANDERMEIJDEN, E., VERPOORTE, R. ALLELOPATHIC INHIBITION OF SEED-GERMINATION BY CINCHONA ALKALOIDS. Phytochemistry, 1991, vol. 30, no. 9, p. 2947-2951. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature