Botanical species · safety record

Cinchona pubescens

The EFSA Compendium of Botanicals holds 12 constituent measurements and 1 adverse-effect record for Cinchona pubescens. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Cinchona pubescens Vahl

12Constituent measurements

1Safety records

3Cited sources

20Licensed products (Canada)

Also recorded as

Cinchona succirubra Pav. ex Klotzsch

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 20 licensed products naming Cinchona pubescens as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Bark
Dried bark
Dried bark (various Cinchona spp.)
Dried bark from trunk
Dried bark from twigs
Dried bark of young trunks and older twigs
Root
Stem bark

What the records describe

Constituents measured

Plant parts

Preparations

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cinchonidine	Bark	Solvent extraction	22 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Cinchonine	Bark	Solvent extraction	37 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Quinidine	Bark	Solvent extraction	2.9 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Quinine	Bark	Solvent extraction	15 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Cinchonidine	Roots and other underground parts	Solvent extraction	0.1 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Cinchonidine	Aerial part of plants	Solvent extraction	0.06 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Cinchonine	Aerial part of plants	Solvent extraction	0.1 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Cinchonine	Roots and other underground parts	Solvent extraction	0.27 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Quinidine	Roots and other underground parts	Solvent extraction	0.05 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Quinidine	Aerial part of plants	Solvent extraction	0.01 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Quinine	Roots and other underground parts	Solvent extraction	0.13 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Quinine	Aerial part of plants	Solvent extraction	0.07 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Not stated	Heart	—	Solvent extraction	Human (as organism)	Case report	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Fabiano-Tixier, Anne-Sylvie., Elomri, Abdelhakim., Blanckaert, Axelle., Seguin, Elisabeth., Petitcolas, Emmanuel., Chemat, Farid. Rapid and Green Analytical Method for the Determination of Quinoline Alkaloids from Cinchona succirubra Based on Microwave-Integrated Extraction and Leaching (MIEL) Prior to High Performance Liquid Chromatography . International journal of molecular sciences, 2011, vol. 12, no. 11, p. 7846-7860. DOI
Staba, E. John., Chung, Alex C. Quinine and quinidine production by cinchona leaf, root and unorganized cultures. Phytochemistry (elsevier), 1981, vol. 20, no. 11, p. 2495-8.
Durasnel, P., Vanhuffel, L., Blonde, R., Lion, F., Galas, T., Mousset-Hovaere, M., Balay, I., Viscardi, G., Valyi, L. Severe poisoning by plants used for traditional medicine in Mayotte .. Bulletin de la societe de pathologie exotique (1990), 2014, vol. 107, no. 5, p. 306-11. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature