Botanical species · safety record

Cinnamomum verum

The EFSA Compendium of Botanicals holds 9 constituent measurements, 4 adverse-effect records and 1 genotoxicity assay for Cinnamomum verum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Cinnamomum verum J.Presl.

9Constituent measurements

5Safety records

6Cited sources

473Licensed products (Canada)

Also recorded as

Cinnamomum zeylanicum Blume

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 473 licensed products naming Cinnamomum verum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Aged bark
Bark
Bark (powder)
Bark extract
Branch bark
Branch(es)
Cinnamomum aromaticum - Branch bark
Cinnamomum verum

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Bark	Solvent extraction	—	Phytochemical screening	Resolve DOI
Anthraquinone	Bark	Solvent extraction	—	Phytochemical screening	Resolve DOI
Cinnamaldehyde	Bark	Solvent extraction	≥ 2080 Milligram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Cinnamaldehyde	Bark	Solvent extraction	≤ 28200 Milligram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Cinnamyl alcohol	Bark	Solvent extraction	< 946 Milligram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Coumarin	Bark	Solvent extraction	< 486 Milligram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Coumarins	Bark	Solvent extraction	—	Phytochemical screening	Resolve DOI
Eugenol	Bark	Solvent extraction	< 8140 Milligram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Tannins	Bark	Solvent extraction	—	Phytochemical screening	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	—	Bark	Solvent extraction	—	In vitro	Resolve DOI
Systemic	Liver	Unspecified	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Developmental	Uterus	—	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier
Systemic	Stomach	Unspecified	Raw, no heat treatment	House mouse (as animal)	Chronic/long term toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	—	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	No data	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Balachandran, B., Sivaramkrishnan, V. M. Induction of tumours of Indian dietary constituents. Indian journal of cancer, 1995, vol. 32, no. 3, p. 104-109.
Mahmoud, I., Alkofahi, A., Abdelaziz, A. Mutagenic and toxic activities of several spices and some jordanian medicinal plants. Pharmaceutical biology, 1992, vol. 30, no. 2, p. 81-85. DOI
Mohamed Sham Shihabudeen, H., Hansi Priscilla, D., Thirumurugan, Kavitha. Cinnamon extract inhibits alpha-glucosidase activity and dampens postprandial glucose excursion in diabetic rats. . Nutrition & metabolism, 2011, vol. 8, no. 1, p. 46-46. DOI
Pellegatti Lemonica, I., Borro Macedo, A. M. R. Abortive and/or embryofetotoxic effect of Cinnamomum zeylanicum leaf extracts in pregnant rats . Fitoterapia, 1994, vol. 65, no. 5, p. 431-434.
Shah, AH., Al-Shareef, AH., Ageel, AM., Qureshi, S. Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits . Plant foods for human nutrition, 1998, vol. 52, no. 3, p. 231-239. DOI
Woehrlin, Friederike., Fry, Hildburg., Abraham, Klaus., Preiss-Weigert, Angelika. Quantification of Flavoring Constituents in Cinnamon: High Variation of Coumarin in Cassia Bark from the German Retail Market and in Authentic Samples from Indonesia . Journal of agricultural and food chemistry, 2010, vol. 58, no. 19, p. 10568-10575. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature