Botanical species · safety record

Cissampelos pareira

The EFSA Compendium of Botanicals holds 15 constituent measurements and 8 adverse-effect records for Cissampelos pareira. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Cissampelos pareira L.

15Constituent measurements

8Safety records

9Cited sources

4Licensed products (Canada)

Also recorded as

Cissampelos pareira var. hirsuta (Buch.-Ham. ex DC.) Forman

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 4 licensed products naming Cissampelos pareira as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Calcium oxalate	Leaves	—	—	Microscopic detection	Resolve DOI
Isoquinoline alkaloids	Roots and other underground parts	Solvent extraction	—	Element spectroscopy	Resolve DOI
Isoquinoline alkaloids	Roots and other underground parts	Solvent extraction	4e-04 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
1-bebeerine	Roots and other underground parts	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Alkaloids	Roots and other underground parts	Solvent extraction	6.61 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Calcium oxalate	Roots and other underground parts	—	—	Microscopic detection	No resolvable identifier
Hayatine	Roots and other underground parts	—	—	—	No resolvable identifier
Isoquinoline alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Isoquinoline alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Isoquinoline alkaloids	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Pareirubrine a	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Pareirubrine b	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Tannins	Roots and other underground parts	Solvent extraction	14.78 Percent	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Reproductive	Urogenital	Leaves	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Urogenital	Leaves	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Urogenital	Leaves	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Urogenital	Leaves	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Urogenital	Leaves	Drying (dehydration)	House mouse (as animal)	Reproduction toxicity	No resolvable identifier
Reproductive	Urogenital	Leaves	Drying (dehydration)	House mouse (as animal)	Reproduction toxicity	No resolvable identifier
Reproductive	Urogenital	Leaves	Drying (dehydration)	House mouse (as animal)	Reproduction toxicity	No resolvable identifier
Reproductive	Urogenital	Leaves	Drying (dehydration)	House mouse (as animal)	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Ganguly, Mausumi., Borthakur, Mridul Kr., Devi, Nirada., Mahanta, Rita. Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice . Journal of ethnopharmacology, 2007, vol. 111, no. 3, p. 688-691. DOI
Junaimuang, T., Luangpirom, A., Somsapt, P. Antiepileptic antifertility properties of Cissampelos pareira Linn. leaf gel in male and female mice. International journal of phytomedicine, 2015, vol. 7, no. 1, p. 112-118.
MORITA, H., MATSUMOTO, K., TAKEYA, K., ITOKAWA, H., IITAKA, Y. STRUCTURES AND SOLID-STATE TAUTOMERIC FORMS OF 2 NOVEL ANTILEUKEMIC TROPOLOISOQUINOLINE ALKALOIDS, PAREIRUBRINE-A AND PAREIRUBRINE-B, FROM CISSAMPELOS-PAREIRA . Chemical & pharmaceutical bulletin, 1993, vol. 41, no. 8, p. 1418-1422.
MORITA, H., MATSUMOTO, K., TAKEYA, K., ITOKAWA, H. AZAFLUORANTHENE ALKALOIDS FROM CISSAMPELOS-PAREIRA. Chemical & pharmaceutical bulletin, 1993, vol. 41, no. 7, p. 1307-1308.
Hullatti, K. K., Sharada, M. S. Comparative phytochemical investigation of the sources of ayurvedic drug Patha: A chromatographic fingerprinting analysis . Indian journal of pharmaceutical sciences, 2010, vol. 72, no. 1, p. 39-45.
Sudhakaran, M.V. Histo-morphological, fluorescent and powder microscopic characterization of Cissampelos pareira Linn.. Pharmacognosy journal, 2012, vol. 4, no. 34, p. 57-68. DOI
Mukerji, B., Bhandari, P. R. Cissampelos pareira, source of a new curariform drug. Planta medica, 1959, vol. 7, p. 250-9.
ANWER, F., POPLI, SP., SRIVASTA.RM., KHARE, MP. STUDIES IN MEDICINAL PLANTS .3. PROTOBERBERINE ALKALOIDS FROM ROOTS OF CISSAMPELOS PAREIRA LINN . Experientia, 1968, vol. 24, no. 10, p. 999-&. DOI
MORITA, H., TAKEYA, K., ITOKAWA, H. A NOVEL CONDENSED TROPONE-ISOQUINOLINE ALKALOID, PAREITROPONE, FROM CISSAMPELOS-PAREIRA . Bioorganic & medicinal chemistry letters, 1995, vol. 5, no. 6, p. 597-598. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature