Botanical species · safety record

Cissus quadrangularis

The EFSA Compendium of Botanicals holds 6 constituent measurements, 2 adverse-effect records and 1 genotoxicity assay for Cissus quadrangularis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Cissus quadrangularis L.

6Constituent measurements

3Safety records

5Cited sources

79Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 79 licensed products naming Cissus quadrangularis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Aged bark
Cissus quadrangularis - Leaf
Fruit
Herb
Leaf
Leaf and stem
Stem
Stem (standardized extract)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Stem / stalk	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Alkaloids	Aerial part of plants	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Calcium oxalate	Leaves	Powder	—	Electron microscopical tests	No resolvable identifier
Saponins	Stem / stalk	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Saponins	Live plants	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannins	Live plants	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Unspecified	Solvent extraction	—	In vitro	No resolvable identifier
Digestive	Digestive	Unspecified	Solvent extraction	—	In vitro	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	—	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	No data	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Sharp, Hazel., Hollinshead, Jackie., Bartholomew, Barbara B., Oben, Julius., Watson, Alison., Nash, Robert J. Inhibitory effects of Cissus quadrangularis L. derived components on lipase, amylase and alpha-glucosidase activity in vitro . Natural product communications, 2007, vol. 2, no. 8, p. 817-822.
Teware, K., Singh, P., Mehta, R. Phytochemical extraction and analysis of medicinally important plant Cissus qudrangularis L. (Hadjod). Biomedical and Pharmacology Journal, 2011, vol. 4, no. 1, p. 175-179.
Nathar Varsha, N., Yatoo Ghulam, M. Investigation on secondary metabolites in Cissus Quadrangularis linn. International Journal of Pharma and Bio Sciences, 2015, vol. 6, no. 2, p. P349-P353.
Sivaswamy, S N., Balachandran, B., Balanehru, S., Sivaramakrishnan, V M. Mutagenic activity of south Indian food items.. Indian journal of experimental biology, 1991, vol. 29, no. 8, p. 730-7.
Anitha, R., Sandhiya, T. Occurrence of calcium oxalate crystals in the leaves of medicinal plants. International Journal of Pharmacognosy (Panchkula, India), 2014, p. 389-393.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature