Botanical species · safety record

Citrus sinensis

The EFSA Compendium of Botanicals holds 10 constituent measurements for Citrus sinensis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Citrus sinensis (L.) Osbeck

10Constituent measurements

0Safety records

5Cited sources

493Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 493 licensed products naming Citrus sinensis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Fresh

Source material stated

Aged bark
Bark
Citrus aurantium - fruit
Citrus sinensis - Fruit peel
Citrus sinensis - fruit
Flower
Fruit
Fruit (dry-fried)

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Bergapten	Aerial part of plants	Essential oil	4 Percent	GC-MS	Resolve DOI
Myrcene	Fruit peel	Essential oil	1.5 Percent	GC-MS	Resolve DOI
Synephrine	Fruit unspecified	Solvent extraction	≤ 0.1 Percent	HPLC-UV	Resolve DOI
Synephrine	Fruit unspecified	Solvent extraction	≥ 0.02 Percent	HPLC-UV	Resolve DOI
Bergapten	Fruit peel	Solvent extraction	0.13 Percent	Gaschromatography (GC)	No resolvable identifier
Bergaptol	Fruit peel	Solvent extraction	0.31 Percent	Gaschromatography (GC)	No resolvable identifier
Gallic acid	Leaves	Solvent extraction	0.5 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Isoimperatorin	Fruit peel	Solvent extraction	0.12 Percent	Gaschromatography (GC)	No resolvable identifier
Osthol	Fruit peel	Solvent extraction	0.02 Percent	Gaschromatography (GC)	No resolvable identifier
Scoparone	Fruit peel	Solvent extraction	0.11 Percent	Gaschromatography (GC)	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Mohamed, TK. Chemical constituents and antioxidant activity of Citrus paradisi (star-ruby red grapefruit) and Citrus sinensis (blood sweet orange) Egyptian cultivars . Asian journal of chemistry, 2004, vol. 16, no. 3-4, p. 1753-1764.
Arbo, M. D., Larentis, E. R., Linck, V. M., Aboy, A. L., Pimentel, A. L., Henriques, A. T., Dallegrave, E., Garcia, S. C., Leal, M. B., Limberger, R. P. Concentrations of p-synephrine in fruits and leaves of Citrus species (Rutaceae) and the acute toxicity testing of Citrus aurantium extract and p-synephrine. FOOD AND CHEMICAL TOXICOLOGY, 2008, vol. 46, no. 8, p. 2770-2775. DOI
Giatropoulos, Athanassios., Papachristos, Dimitrios P., Kimbaris, Athanasios., Koliopoulos, George., Polissiou, Moschos G., Emmanouel, Nickolaos., Michaelakis, Antonios. Evaluation of bioefficacy of three Citrus essential oils against the dengue vector Aedes albopictus (Diptera: Culicidae) in correlation to their components enantiomeric distribution . Parasitology research, 2012, vol. 111, no. 6, p. 2253-2263. DOI
Traboulsi, AF., El-Haj, S., Tueni, M., Taoubi, K., Nader, NA., Mrad, A. Repellency and toxicity of aromatic plant extracts against the mosquito Culex pipiens molestus (Diptera : Culicidae) . Pest management science, 2005, vol. 61, no. 6, p. 597-604. DOI
Tedesco, M., Kuhn, A.W., Boligon, A.A., Laughinghouse Iv, H.D., Athayde, M.L., Da Silva, A.C.F., Tedesco, S.B. Chromatographic analysis, antiproliferative effect and genotoxicity of aqueous extracts of citrus sinensis (L.) osbeck on the allium cepa l. test system An�lise cromatogr�fica, efeito antiproliferativo e genotoxicidade de extratos aquosos de citrus sinensis (L.) osbeck sobre o sistema teste de allium cepa L . Bioscience journal, 2015, vol. 31, no. 4, p. 1213-1221.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature