Botanical species · safety record

Cola nitida

The EFSA Compendium of Botanicals holds 21 constituent measurements and 3 adverse-effect records for Cola nitida. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Cola nitida (Vent.) Schott & Endl.

21Constituent measurements

3Safety records

8Cited sources

29Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 29 licensed products naming Cola nitida as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Cotyledon
Dried seed(s)
Fruit
Graine
New material
Nut(s)
Seed
Seed Germ

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Caffeine	Seed	Solvent extraction	≥ 2728 Milligram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Caffeine	Seed	Solvent extraction	≤ 19302 Milligram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Theobromine	Seed	Solvent extraction	≤ 1570 Milligram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Theobromine	Seed	Solvent extraction	≥ 37 Milligram/kilogram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alkaloids	Seed	—	≤ 2.81 Percent	Unspecified	No resolvable identifier
Alkaloids	Seed	—	≥ 2.75 Percent	Unspecified	No resolvable identifier
Alkaloids	Seed	—	2.06 Percent	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Amygdalin	Seed	Solvent extraction	55.05 Milligram/gram	UV/VIS spectroscopy (photometry)	No resolvable identifier
Anthraquinone	Seed	—	≤ 0.081 Percent	Unspecified	No resolvable identifier
Anthraquinone	Seed	—	≥ 0.076 Percent	Unspecified	No resolvable identifier
Caffeine	Seed	—	≥ 1.06 Percent	—	No resolvable identifier
Caffeine	Seed	—	≤ 1.13 Percent	—	No resolvable identifier
Cardiac glycosides	Seed	Solvent extraction	42.6 Milligram/100 gram	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Cyanogenic glycosides	Seed	Solvent extraction	60.06 Milligram/100 gram	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Oxalates	Seed	Solvent extraction	1.04 Milligram/100 gram	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Oxalates	Seed	—	0.44 Percent	Unspecified	No resolvable identifier
Phytic acid	Seed	—	0.87 Percent	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Saponins	Seed	—	≤ 0.52 Percent	—	No resolvable identifier
Saponins	Seed	—	≥ 0.49 Percent	—	No resolvable identifier
Saponins	Seed	Solvent extraction	10.49 Milligram/100 gram	Traditional analytical techniques (wet chemical tests)	No resolvable identifier
Saponins	Seed	—	4.66 Percent	Traditional analytical techniques (wet chemical tests)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Other toxicities	Heart	Seed	Powder	Rat (as animal)	Short-term toxicity	Resolve DOI
Other toxicities	—	Seed	Solvent extraction	Rat (as animal)	Subchronic	No resolvable identifier
Reproductive	Testes	Seed	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Bolarinwa, Islamiyat Folashade., Olaniyan, Sulaiman Adebisi., Olatunde, Sogo James., Ayandokun, Feyisayo Temilade., Olaifa, Ifasegun Alade. Effect of processing on amygdalin and cyanide contents of some Nigerian foods. Journal of chemical and pharmaceutical research, 2016, vol. 8, no. 2, p. 106-113.
Osim, E.E., Udia, P.M. Effects of consuming a kola nut (cola nitida) diet on mean arterial pressure in rats. Pharmaceutical biology, 1993, vol. 31, no. 3, p. 193-197. DOI
Oyedeji, K.O., Bolarinwa, A.F., Adegoke, A.O. Effect of aqueous extract of Cola nitida (Kola nut) on reproductive functionsin male albino rats. International journal of pharmaceutical sciences review and research, 2013, vol. 20, no. 2, p. 291-295.
Salahdeen, H. M., Omoaghe, A. O., Isehunwa, G. O., Murtala, B. A., Alada, A. R. A. Gas chromatography mass spectrometry (GC-MS) analysis of ethanolic extracts of kolanut (Cola nitida) (vent) and its toxicity studies in rats. Journal of medicinal plants research, 2015, vol. 9, no. 3, p. 56-70.
Atanda, O. O., Olutayo, A., Mokwunye, F. C., Oyebanji, A. O., Adegunwa, M. O. The quality of Nigerian kola nuts. African journal of food science, 2011, vol. 5, no. 17, p. 904-909.
Dah-Nouvlessounon, Durand., Adjanohoun, Adolphe., Sina, Haziz., Noumavo, Pacome A., Diarrasouba, Nafan., Parkouda, Charles., Madode, Yann E., Dicko, Mamoudou H., Baba-Moussa, Lamine. Nutritional and anti-nutrient composition of three kola nuts (Cola nitida, Cola acuminata and Garcinia kola) produced in Benin. Food and nutrition sciences, 2015, vol. 6, no. 15, p. 1395-1407.
Niemenak, N., Onomo, P. E., Fotso., Lieberei, R., Ndoumou, D. O. Purine alkaloids and phenolic compounds in three Cola species and Garcinia kola grown in Cameroon . South african journal of botany, 2008, vol. 74, no. 4, p. 629-638. DOI
Monago, C. C., Uwakwe, A. A. Tannin, oxalate, saponin, cyanogenic and cardiac glycosides contents of Cola nitida and Cola acuminata. Global journal of pure and applied sciences, 2005, vol. 11, no. 4, p. 501-504.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature