Botanical species · safety record

Colchicum autumnale

The EFSA Compendium of Botanicals holds 1 constituent measurement and 17 adverse-effect records for Colchicum autumnale. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Colchicum autumnale L.

1Constituent measurements

17Safety records

9Cited sources

71Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 71 licensed products naming Colchicum autumnale as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Bulb
Bulbs dug in spring
Bulbus
Corm(s)
Fresh bulbs in spring
Fresh corms collected during spring
Fresh corms, collected in spring
Seeds (HAB 1958)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Colchicin	Bulb / clove	—	0.04 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Bulb / clove	Drying (dehydration)	Cattle (as animal)	Case report	Resolve DOI
Digestive	Digestive	Bulb / clove	Raw, no heat treatment	Guinea pig (as animal)	Acute toxicity	Resolve DOI
Digestive	Digestive	Bulb / clove	Drying (dehydration)	Cattle (as animal)	Case report	Resolve DOI
Digestive	Digestive	Bulb / clove	Raw, no heat treatment	House mouse (as animal)	Acute toxicity	Resolve DOI
Hemopoietic	Digestive	Bulb / clove	Drying (dehydration)	Cattle (as animal)	Case report	Resolve DOI
Hepatotoxicity	Digestive	Unspecified	—	Human (as organism)	Case report	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Unspecified	—	Human (as organism)	Case report	Resolve DOI
Neurotoxicity	Neurologic	Bulb / clove	Raw, no heat treatment	Guinea pig (as animal)	Acute toxicity	Resolve DOI
Neurotoxicity	Brain	Unspecified	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Blood coagulation	Unspecified	—	Human (as organism)	Case report	Resolve DOI
Systemic	—	Bulb / clove	Drying (dehydration)	Cattle (as animal)	Case report	Resolve DOI
Systemic	—	Bulb / clove	Drying (dehydration)	Cattle (as animal)	Case report	Resolve DOI
Systemic	—	Leaves	—	Human (as organism)	Case report	Resolve DOI
Systemic	—	Leaves	—	Human (as organism)	Case report	Resolve DOI
Systemic	Digestive	Live plants	—	Human (as organism)	Case report	Resolve DOI
Digestive	Digestive	Flower	Fresh	Human (as organism)	Case report	No resolvable identifier
Hemopoietic	Cardiovascular / haematological	Unspecified	Raw, no heat treatment	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Fuchs, Joan., Rauber-Luethy, Christine., Kupferschmidt, Hugo., Kupper, Jacqueline., Kullak-Ublick, Gerd-Achim., Ceschi, Alessandro. Acute plant poisoning: Analysis of clinical features and circumstances of exposure . Clinical toxicology, 2011, vol. 49, no. 7, p. 671-680. DOI
Yamada, M., Matsui, T., Kobayashi, Y., Furuoka, H., Haritani, M., Kobayashi, M., Nakagawa, M. Supplementary report on experimental autumn crocus (Colchicum autumnale L.) poisoning in cattle: Morphological evidence of apoptosis . Journal of veterinary medical science, 1999, vol. 61, no. 7, p. 823-825. DOI
Galland-Decker, Coralie., Charmoy, Alexia., Jolliet, Philippe., Spertini, Olivier., Hugli, Olivier., Pantet, Olivier. PROGRESSIVE ORGAN FAILURE AFTER INGESTION OF WILD GARLIC JUICE. Journal of emergency medicine, 2016, vol. 50, no. 1, p. 55-60. DOI
Yamada, M., Nakagawa, M., Haritani, M., Kobayashi, M., Furuoka, H., Matsui, T. Histopathological study of experimental acute poisoning of cattle by autumn crocus (Colchicum autumnale L.) . Journal of veterinary medical science, 1998, vol. 60, no. 8, p. 949-952. DOI
Yamada, M., Kobayashi, Y., Furuoka, H., Matsui, T. Comparison of enterotoxicity between autumn crocus (Colchicum autumnale L.) and colchicine in the guinea pig and mouse: Enterotoxicity in the guinea pig differs from that in the mouse . Journal of veterinary medical science, 2000, vol. 62, no. 8, p. 809-813. DOI
Finkelstein, Yaron., Aks, Steven E., Hutson, Janine R., Juurlink, David N., Nguyen, Patricia., Dubnov-Raz, Gal., Pollak, Uri., Koren, Gideon., Bentur, Yedidia. Colchicine poisoning: the dark side of an ancient drug. Clinical toxicology, 2010, vol. 48, no. 5, p. 407-414. DOI
Fezer Gabor., Toth Balazs. The intoxication of equidae (horses) with colchicines. Magyar allatorvosok lapja, 2016, vol. 138, no. 12, p. 707-712.
Danel, VC., Wiart, JFD., Hardy, GA., Vincent, FH., Houdret, NMP. Self-poisoning with Colchicum autumnale L. flowers. Journal of toxicology-clinical toxicology, 2001, vol. 39, no. 4, p. 409-411.
Brncic, N., Viskovic, I., Peric, R., Dirlic, A., Vitezic, D., Cuculic, D. Accidental plant poisoning with Colchicum autumnale: Report of two cases. Croatian medical journal, 2001, vol. 42, no. 6, p. 673-675.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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